Food Lectins in Health and Disease: An Introduction
... specifically recognize galactose residues. It is believed that these cellsurface receptors are responsible for the removal of certain glycoproteins from the circulatory system. Another lectin is a receptor which recognizes hydrolytic enzymes containing mannose-6-phosphate, and subsequently targets t ...
... specifically recognize galactose residues. It is believed that these cellsurface receptors are responsible for the removal of certain glycoproteins from the circulatory system. Another lectin is a receptor which recognizes hydrolytic enzymes containing mannose-6-phosphate, and subsequently targets t ...
In vitro characterisation and expansion of human regulatory T cells
... functional roles within the immune system since they are specialised to present different types of antigens, thereby eliciting different responses. MHC I are located on almost every cell in the body and present endogenous antigens originating from the cytoplasm. They present selfproteins, but also v ...
... functional roles within the immune system since they are specialised to present different types of antigens, thereby eliciting different responses. MHC I are located on almost every cell in the body and present endogenous antigens originating from the cytoplasm. They present selfproteins, but also v ...
COLOSTRUM THE WHITE GOLD DISCOVERY
... Powerful antibacterial, anti-inflammatory antiviral agent. In helping the body to more effectively use iron, Lactoferrin deprives bacteria of the mineral, making it impossible for the antigen to reproduce. Lactoferrin also has the ability to latch onto bacteria and, in a sense, weaken them until oth ...
... Powerful antibacterial, anti-inflammatory antiviral agent. In helping the body to more effectively use iron, Lactoferrin deprives bacteria of the mineral, making it impossible for the antigen to reproduce. Lactoferrin also has the ability to latch onto bacteria and, in a sense, weaken them until oth ...
maitake mushroom
... with deleterious side effects, in tumor-bearing mice. They demonstrated that by enhancing the T helper (Th)1-dominant response, D-fraction decreases the amount of MMC required to manage cancer. Although further studies are required to clarify whether combined therapy using D-fraction is effective, t ...
... with deleterious side effects, in tumor-bearing mice. They demonstrated that by enhancing the T helper (Th)1-dominant response, D-fraction decreases the amount of MMC required to manage cancer. Although further studies are required to clarify whether combined therapy using D-fraction is effective, t ...
against Oviduct Disease to Induce Immune Pathology and Protect
... the activity of pathogen-specific T cells (27). We have shown that TLR2-deficient mice do not develop oviduct pathology after chlamydial infection, demonstrating that TLR2 signaling is directly involved in disease development (28). Because chlamydiae are present as both extra- and intracellular/intr ...
... the activity of pathogen-specific T cells (27). We have shown that TLR2-deficient mice do not develop oviduct pathology after chlamydial infection, demonstrating that TLR2 signaling is directly involved in disease development (28). Because chlamydiae are present as both extra- and intracellular/intr ...
The Hematologic System as a Marker of Organ Dysfunction in Sepsis
... is a simple laboratory test with scores that are elevated in patients with sepsis and decreased in patients with chronic myelogenous leukemia. Treatment During the past several years, the therapeutic potential of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) or granulocyte co ...
... is a simple laboratory test with scores that are elevated in patients with sepsis and decreased in patients with chronic myelogenous leukemia. Treatment During the past several years, the therapeutic potential of recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) or granulocyte co ...
Initiation and Regulation of Type 2 Immunity and Inflammation at
... examine the cellular requisites for initiating Th2 cytokine-dependent immunity and inflammation in the gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediat ...
... examine the cellular requisites for initiating Th2 cytokine-dependent immunity and inflammation in the gastrointestinal tract utilizing infection with the helminth Trichuris muris. By genetic restriction of MHC class II expression to CD11c+ DCs we demonstrate that, in contrast to Th1-cytokine-mediat ...
M.Phil Medical Laboratory Sciences Two Years Degree Programme
... different specialties of medical laboratory sciences. MISSION It is the mission of the MPhil in Medical Laboratory Sciences program at the department of Allied Health Sciences, to help students develop specialized knowledge, skill, attitude and clinical judgment required for competency as medical la ...
... different specialties of medical laboratory sciences. MISSION It is the mission of the MPhil in Medical Laboratory Sciences program at the department of Allied Health Sciences, to help students develop specialized knowledge, skill, attitude and clinical judgment required for competency as medical la ...
World J Gastroenterol
... complex world of cells and molecules involved in less antigen-specific tasks collectively dedicated to the function of innate immunity. Two competing models have sought to explain innate immunity. One where evolutionary conserved features of pathogens are recognized by pattern recognizing receptors[ ...
... complex world of cells and molecules involved in less antigen-specific tasks collectively dedicated to the function of innate immunity. Two competing models have sought to explain innate immunity. One where evolutionary conserved features of pathogens are recognized by pattern recognizing receptors[ ...
Rhesus rhadinovirus vIRF R12 disrupts the PML
... infection in host. During latent infection, only a small number of viral proteins are expressed to trigger minimal host immune responses, and the viral genome is kept as episomes in infected nucleus (4). The latently infected cells usually maintain a normal metabolism, instead of being lysed by lyti ...
... infection in host. During latent infection, only a small number of viral proteins are expressed to trigger minimal host immune responses, and the viral genome is kept as episomes in infected nucleus (4). The latently infected cells usually maintain a normal metabolism, instead of being lysed by lyti ...
Influenza: A case study
... Influenza is a myxovirus belonging to the family of viruses known as Orthomyxoviridae. The virus was originally confined to aquatic birds, but it made the transition to humans 6000–9000 years ago, coinciding with the rise of farming, animal husbandry and urbanisation. These changes in human behavior ...
... Influenza is a myxovirus belonging to the family of viruses known as Orthomyxoviridae. The virus was originally confined to aquatic birds, but it made the transition to humans 6000–9000 years ago, coinciding with the rise of farming, animal husbandry and urbanisation. These changes in human behavior ...
Tissue-Expressed B7x Affects the Immune Response to and and
... B7x protein is expressed in the lung, but not in lymphoid tissues Previously, B7x mRNA expression was detected in both lymphoid and peripheral nonlymphoid tissues (3–5). However, levels in nonlymphoid tissues, such as the lung, were much higher than in lymphoid tissues (3, 6). In this study, we used ...
... B7x protein is expressed in the lung, but not in lymphoid tissues Previously, B7x mRNA expression was detected in both lymphoid and peripheral nonlymphoid tissues (3–5). However, levels in nonlymphoid tissues, such as the lung, were much higher than in lymphoid tissues (3, 6). In this study, we used ...
Teil 1: „Studies on the extracellular matrix enzyme
... The discovery of the matrix enzyme lysyl oxidase (LOX) emerged from the convergence of mainly two research areas. Already the greek philosopher Hippocrates reported that chronic ingestion of the sweet pea Lathyrus odoratus can result in a disease today referred to as lathyrism. Studies with experime ...
... The discovery of the matrix enzyme lysyl oxidase (LOX) emerged from the convergence of mainly two research areas. Already the greek philosopher Hippocrates reported that chronic ingestion of the sweet pea Lathyrus odoratus can result in a disease today referred to as lathyrism. Studies with experime ...
Sphingosine-1-Phosphate Metabolism and Its Role in the
... inflammatory bowel disease (IBD), a chronic inflammatory disorder of the digestive tract [1]. Both UC and CD present with similar symptoms including diarrhea, abdominal pain, weight loss, and fever [2]. These disorders are characterized by periods of relapse and remission [1,3,4], with destructive c ...
... inflammatory bowel disease (IBD), a chronic inflammatory disorder of the digestive tract [1]. Both UC and CD present with similar symptoms including diarrhea, abdominal pain, weight loss, and fever [2]. These disorders are characterized by periods of relapse and remission [1,3,4], with destructive c ...
Review - American Physiological Society
... Transcription factors: Protein factors that interact with promoters and upstream regulatory elements on the DNA of the protein that will be expressed. Transduction: Transfer of genetic material from one cell to another. Also, transmission of cell surface signals into the nucleus. Transforming growth ...
... Transcription factors: Protein factors that interact with promoters and upstream regulatory elements on the DNA of the protein that will be expressed. Transduction: Transfer of genetic material from one cell to another. Also, transmission of cell surface signals into the nucleus. Transforming growth ...
Tissue Microenvironments Define and Get Reinforced by
... hence PAMPs and DAMPs will lead to their full activation through a process similar to what has been referred to as ‘classical-M1 macrophage activation’ in in vitro studies [1]. Inflammatory macrophages secrete IL-1, IL12, IL-23, tumor necrosis factor (TNF)-␣ and ROS, and express inducible nitric oxi ...
... hence PAMPs and DAMPs will lead to their full activation through a process similar to what has been referred to as ‘classical-M1 macrophage activation’ in in vitro studies [1]. Inflammatory macrophages secrete IL-1, IL12, IL-23, tumor necrosis factor (TNF)-␣ and ROS, and express inducible nitric oxi ...
... has caused or is causing an allergic reaction in the first place. We might suspect certain culprits, however, there could be a variety and a combination of substances involved. Over the last twenty years or more there have been huge changes in food technology. The advent of genetic modification, the ...
Dissertation LeWi Fakultät Humboldt-Universität zu Berlin
... Analyses of the clinical and morphological picture in patients suffering from dermatomyositis showed that juvenile patients have very characteristic symptoms, like dysphagia and calcifications of skeletal muscles that are not part of the disease in adults. On the other hand, both diseases are consi ...
... Analyses of the clinical and morphological picture in patients suffering from dermatomyositis showed that juvenile patients have very characteristic symptoms, like dysphagia and calcifications of skeletal muscles that are not part of the disease in adults. On the other hand, both diseases are consi ...
BioE HIV AIDS
... the viral life cycle. FDA has approved eight such drugs--saquinavir, ritonavir, indinavir, amprenavir, nelfinavir, fosamprenavir, atazanavir, and lopinavir-for marketing in the United States. An HIV inhibitor that targets a unique step in the viral life cycle, very late in the process of viral matur ...
... the viral life cycle. FDA has approved eight such drugs--saquinavir, ritonavir, indinavir, amprenavir, nelfinavir, fosamprenavir, atazanavir, and lopinavir-for marketing in the United States. An HIV inhibitor that targets a unique step in the viral life cycle, very late in the process of viral matur ...
Bee products as immunopotentiation Honey
... Honey stimulates antibodies, B and T lymphocytes, neutrophils, monocytes, eosinophils, and natural killer cells (NKcells) production during primary and secondary immune responses in tissue culture. ...
... Honey stimulates antibodies, B and T lymphocytes, neutrophils, monocytes, eosinophils, and natural killer cells (NKcells) production during primary and secondary immune responses in tissue culture. ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.