![Vitiligo, Depigmentation And Monobenzone](http://s1.studyres.com/store/data/006555226_1-45a6c5d6192d6fa80b2e853bf8030dde-300x300.png)
Integr. Comp. Biol.-2011-Rollins-Smith-552
... immune defense against B. dendrobatidis Previous studies of the ontogenetic development of the immune system of anuran amphibians showed that the immune system develops in two phases. The first is a rapid expansion during the tadpole’s life followed by a significant loss of lymphocytes during the cl ...
... immune defense against B. dendrobatidis Previous studies of the ontogenetic development of the immune system of anuran amphibians showed that the immune system develops in two phases. The first is a rapid expansion during the tadpole’s life followed by a significant loss of lymphocytes during the cl ...
Autoimmunity to glomerular antigens in
... 3. Sera from 16 of the 26 patients with HenochSchoenlein nephritis displayed increased IgG binding to the human glomerular extract compared with the normal control group (P<0.001), whereas IgG binding was not significantly raised in the patients with Henoch-Schoenlein purpura without evidence of ren ...
... 3. Sera from 16 of the 26 patients with HenochSchoenlein nephritis displayed increased IgG binding to the human glomerular extract compared with the normal control group (P<0.001), whereas IgG binding was not significantly raised in the patients with Henoch-Schoenlein purpura without evidence of ren ...
Testing the Effect of Changing Heat Shock Protein 90:
... Preclinical trials emphasize the important role of Hsp90 inhibitors in clinical applications. Combination therapies, applying low doses of these drugs together with convention chemotherapeutic agents, seem to be an effective way to target various cancers. For example, in the case of Bcr/Abl-expressi ...
... Preclinical trials emphasize the important role of Hsp90 inhibitors in clinical applications. Combination therapies, applying low doses of these drugs together with convention chemotherapeutic agents, seem to be an effective way to target various cancers. For example, in the case of Bcr/Abl-expressi ...
Bioassay-Validated Recombinant Cytokines
... Mouse FGF-basic Other names: Fibroblast growth factor 2, Fgf-2, Fgfb, bFGF FGF-basic (FGFb) is a member of the fibroblast growth factor (FGF) family which includes 23 members. It is also known as fibroblast growth factor 2, Fgf-2, Fgfb, and bFGF. FGFb is expressed in almost all tissues and plays an ...
... Mouse FGF-basic Other names: Fibroblast growth factor 2, Fgf-2, Fgfb, bFGF FGF-basic (FGFb) is a member of the fibroblast growth factor (FGF) family which includes 23 members. It is also known as fibroblast growth factor 2, Fgf-2, Fgfb, and bFGF. FGFb is expressed in almost all tissues and plays an ...
Killed but metabolically active microbes: a new vaccine paradigm for
... activity could be observed during infection of cultured cells. Expression of LLO is essential for escape of and did not form the signature ‘comet tail’ indicative of cytosolic motilL. monocytogenes from the phagolysosome of the infected host cell, ity18. Quantitative fluorescence microscopy of cytos ...
... activity could be observed during infection of cultured cells. Expression of LLO is essential for escape of and did not form the signature ‘comet tail’ indicative of cytosolic motilL. monocytogenes from the phagolysosome of the infected host cell, ity18. Quantitative fluorescence microscopy of cytos ...
Infantile respiratory syncytial virus and human rhinovirus infections: respective
... RSV infection and host immune response RSV takes a uniquely pernicious position among all respiratory viruses causing respiratory tract infections in young infants due to its cytopathic activity. However, besides the direct cytopathic effect of the virus, the local host inflammatory response plays a ...
... RSV infection and host immune response RSV takes a uniquely pernicious position among all respiratory viruses causing respiratory tract infections in young infants due to its cytopathic activity. However, besides the direct cytopathic effect of the virus, the local host inflammatory response plays a ...
Synthesis and Evaluation of Biological Activity of a Potential
... that penetrated the first line of defense, i.e., the skin and mucous membranes. Antigens are toxins or other foreign substances that induce an immune response in a body by producing antibodies. Innate immune responses which are found in all living organisms ...
... that penetrated the first line of defense, i.e., the skin and mucous membranes. Antigens are toxins or other foreign substances that induce an immune response in a body by producing antibodies. Innate immune responses which are found in all living organisms ...
Chemical basis of ABO subgroups
... There is little doubt that the ABO blood group system and its associated antibodies have a relationship with micro-organisms and infection. However there is no definitive advantage of any one phenotype over another (unlike other blood groups antigens such as Duffy which can prevent life-threatening ...
... There is little doubt that the ABO blood group system and its associated antibodies have a relationship with micro-organisms and infection. However there is no definitive advantage of any one phenotype over another (unlike other blood groups antigens such as Duffy which can prevent life-threatening ...
F1-ATPase`
... of plant mitochondria is quite different. In comparison to the amount of information that has been accumulated in animal systems, very little is actually known about the characteristics of plant mitochondrial F1-ATPase. This is in large part due to the difficulties involved in isolating large quanti ...
... of plant mitochondria is quite different. In comparison to the amount of information that has been accumulated in animal systems, very little is actually known about the characteristics of plant mitochondrial F1-ATPase. This is in large part due to the difficulties involved in isolating large quanti ...
Mucosal candidiasis elicits NF-κB activation, proinflammatory gene
... Fig. 1. Candida albicans infects the swimbladder of juvenile zebrafish. (A-F)Cohorts of 20 AB fish were infected by immersion with C. albicans CAF2-dTomato and imaged by confocal microscopy at 5 dpi (8 dpf). (A)C. albicans immersion, non-infected (NI) with pseudo-coloring; black outline of the swi ...
... Fig. 1. Candida albicans infects the swimbladder of juvenile zebrafish. (A-F)Cohorts of 20 AB fish were infected by immersion with C. albicans CAF2-dTomato and imaged by confocal microscopy at 5 dpi (8 dpf). (A)C. albicans immersion, non-infected (NI) with pseudo-coloring; black outline of the swi ...
Immunogenic Consensus Sequence T Helper Epitopes for a Pan
... cystic fibrosis patients. Since BPM, BM and BC are all intracellular bacteria, they are excellent targets for T cell-based vaccines. However, the sheer volume of available genomic data requires the aid of immunoinformatics for vaccine design. Using EpiMatrix, ClustiMer and EpiAssembler, a set of imm ...
... cystic fibrosis patients. Since BPM, BM and BC are all intracellular bacteria, they are excellent targets for T cell-based vaccines. However, the sheer volume of available genomic data requires the aid of immunoinformatics for vaccine design. Using EpiMatrix, ClustiMer and EpiAssembler, a set of imm ...
Pollen-Induced Oxidative Stress Influences Both Innate and
... maturation, and consequently induce adaptive immune responses. Recently, it has been shown that pollen grains and their allergenic extracts have a potent pro-oxidant activity, which induces profound oxidative stress in the lung or conjunctiva within minutes after exposure (3–5). Inhibition of this i ...
... maturation, and consequently induce adaptive immune responses. Recently, it has been shown that pollen grains and their allergenic extracts have a potent pro-oxidant activity, which induces profound oxidative stress in the lung or conjunctiva within minutes after exposure (3–5). Inhibition of this i ...
Plasma IL-25 is elevated in a subgroup of patients Open Access
... and possibly severe atopic phenotype and, unlike other food allergies (such as CMA), is infrequently outgrown [8]. The original diagnosis of peanut allergy in our tested cohort was not based on an oral challenge and this poses limitations on conclusions about the resolution of peanut allergy. Howeve ...
... and possibly severe atopic phenotype and, unlike other food allergies (such as CMA), is infrequently outgrown [8]. The original diagnosis of peanut allergy in our tested cohort was not based on an oral challenge and this poses limitations on conclusions about the resolution of peanut allergy. Howeve ...
Reviews EVects of exercise on lymphocytes and cytokines
... important fuel for lymphocytes and macrophages. Several lines of evidence suggest that it is used at a very high rate by these cells, even when they are quiescent.34 It has been proposed that the glutamine pathway in lymphocytes may be under external regulation, partly because of the supply of gluta ...
... important fuel for lymphocytes and macrophages. Several lines of evidence suggest that it is used at a very high rate by these cells, even when they are quiescent.34 It has been proposed that the glutamine pathway in lymphocytes may be under external regulation, partly because of the supply of gluta ...
Phytotherapy for Atopic Dermatitis (Eczema)
... Skin lesions are manifestations of a greater disease process. Given that skin disorders involve unspecified disordered metabolism at a deeper level, the use of agents which can effect a change in these processes is required. These agents are known as alteratives or depuratives (see below). They ar ...
... Skin lesions are manifestations of a greater disease process. Given that skin disorders involve unspecified disordered metabolism at a deeper level, the use of agents which can effect a change in these processes is required. These agents are known as alteratives or depuratives (see below). They ar ...
HIV-1 IMMUNE RESPONSES INDUCED BY NATURAL INFECTION
... several explanations as to why HIV‐1/AIDS has spread to become a world wide pandemic. The onset of AIDS is caused by a slow degeneration of the immune system as a consequence of HIV‐1 infection. Thus the infection may have a silent period for many years before onset of serious sympto ...
... several explanations as to why HIV‐1/AIDS has spread to become a world wide pandemic. The onset of AIDS is caused by a slow degeneration of the immune system as a consequence of HIV‐1 infection. Thus the infection may have a silent period for many years before onset of serious sympto ...
Advanced Tests
... • 3. Severe reduction in serum IgG and IgA with increased IgM and normal numbers of B cells (a) AID deficiency(b) UNG deficiency • 4. Isotype or light chain deficiencies with normal numbers of B cells (a) Ig heavy chain deletions (b) κ Chain deficiency (c) Isolated IgG subclass deficiency (d) IgA wi ...
... • 3. Severe reduction in serum IgG and IgA with increased IgM and normal numbers of B cells (a) AID deficiency(b) UNG deficiency • 4. Isotype or light chain deficiencies with normal numbers of B cells (a) Ig heavy chain deletions (b) κ Chain deficiency (c) Isolated IgG subclass deficiency (d) IgA wi ...
Mast cell-orchestrated immunity to pathogens
... also vary with respect to their expression of the receptor for complement component C5a (C5aR)11. Although other inflammatory mediators and surface receptors might also have tissue-type or activation-specific specificity, the varied composition of granules (particularly well characterized for protea ...
... also vary with respect to their expression of the receptor for complement component C5a (C5aR)11. Although other inflammatory mediators and surface receptors might also have tissue-type or activation-specific specificity, the varied composition of granules (particularly well characterized for protea ...
Cross-Clade Protective Immune Responses to Influenza Viruses
... address the need for improved influenza vaccines and alternatives to egg-based manufacturing, we have engineered an influenza virus-like particle (VLP) as a new generation of non-egg or non-mammalian cell culture-based candidate vaccine. Methodology/Principal Findings. We generated from a baculoviru ...
... address the need for improved influenza vaccines and alternatives to egg-based manufacturing, we have engineered an influenza virus-like particle (VLP) as a new generation of non-egg or non-mammalian cell culture-based candidate vaccine. Methodology/Principal Findings. We generated from a baculoviru ...
The function of tumour necrosis factor and receptors in models of
... at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. However, more cryptic functions of this molecule may be considered to play a signific ...
... at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory pathology and tissue damage. However, more cryptic functions of this molecule may be considered to play a signific ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.