![Early steps regulating proliferation and activation in macrophages Ester Sánchez Tilló 2006](http://s1.studyres.com/store/data/008652408_1-0a7b076740cadb6bfc0e0c26622501a3-300x300.png)
Early steps regulating proliferation and activation in macrophages Ester Sánchez Tilló 2006
... As the first line of defense, these cells are able to recognize foreign pathogens and strange particles and phagocytes them. Consequently, they are able to release cytokines to resolve the infection locally and chemokines to recruit a specific cellular response. The presence of certain cytokines pro ...
... As the first line of defense, these cells are able to recognize foreign pathogens and strange particles and phagocytes them. Consequently, they are able to release cytokines to resolve the infection locally and chemokines to recruit a specific cellular response. The presence of certain cytokines pro ...
THE HLA SYSTEM
... sequences, characteristic for certain HLA antigens. These probes will then "type" for the presence of specific DNA sequences of HLA genes. CLINICAL RELEVANCE OF THE HLA SYSTEM Despite the temptation to think of them as "transplantation antigens", HLA antigens are not present on tissues simply to con ...
... sequences, characteristic for certain HLA antigens. These probes will then "type" for the presence of specific DNA sequences of HLA genes. CLINICAL RELEVANCE OF THE HLA SYSTEM Despite the temptation to think of them as "transplantation antigens", HLA antigens are not present on tissues simply to con ...
12146013
... and opposes various environmental assaults to protect the skin which is an important part of the immune system.The delivery of water soluble compounds such as peptides, proteins and vaccines,transdermal route overcome the barrier properties of stratum corneum of the skin. The capillaries, lymphatic, ...
... and opposes various environmental assaults to protect the skin which is an important part of the immune system.The delivery of water soluble compounds such as peptides, proteins and vaccines,transdermal route overcome the barrier properties of stratum corneum of the skin. The capillaries, lymphatic, ...
Intact skin and not stripped skin is crucial for the
... Figure 1 a-Study design for the evaluation of peanut protein passage into blood stream after epicutaneous application on intact or stripped skin. Naive mice were divided into 3 groups (n=10 for each). One group received a ViaskinW loaded with 500μg (ViaskinW-500) applied on intact skin (EPIT), anoth ...
... Figure 1 a-Study design for the evaluation of peanut protein passage into blood stream after epicutaneous application on intact or stripped skin. Naive mice were divided into 3 groups (n=10 for each). One group received a ViaskinW loaded with 500μg (ViaskinW-500) applied on intact skin (EPIT), anoth ...
Brock_Allison_David_2011
... presence of elevated cytokine concentrations has however been shown to be related to conduction deficits due to a phenomenon known as channelopathy. Such effects were shown in a study by Davies et al. (2006), in which the effects of tumour necrosis factor-α on the electrophysiological properties of ...
... presence of elevated cytokine concentrations has however been shown to be related to conduction deficits due to a phenomenon known as channelopathy. Such effects were shown in a study by Davies et al. (2006), in which the effects of tumour necrosis factor-α on the electrophysiological properties of ...
4 results 28.06.13
... with that of untreated controls. The immune activation of peritoneal macrophages was assessed by estimating the ROS and NO content and activation of T and B lymphocytes by observing in vitro lymphocyte proliferation, expression of cell surface CD antigens and production of intracellular Th1/ Th2 cyt ...
... with that of untreated controls. The immune activation of peritoneal macrophages was assessed by estimating the ROS and NO content and activation of T and B lymphocytes by observing in vitro lymphocyte proliferation, expression of cell surface CD antigens and production of intracellular Th1/ Th2 cyt ...
The Lymphatic System
... lymphocytes, the secondary lymphoid organs then nurture the young lymphocytes and initiate an adaptive immune response. In cell mediated immunity naive T-lymphocytes from the thymus, encounter an antigen in circulation either from outside or inside the body and become sensitised to it. They then cir ...
... lymphocytes, the secondary lymphoid organs then nurture the young lymphocytes and initiate an adaptive immune response. In cell mediated immunity naive T-lymphocytes from the thymus, encounter an antigen in circulation either from outside or inside the body and become sensitised to it. They then cir ...
The purpose of this summary is exclusively educational, to provide
... a drug (e.g. HLA-B*57:01 ↑ risk of abacavir hypersensitivity; HLA-B*58:01 ↑ risk of allopurinolinduced SJS/TEN/DRESS; HLA-B*15:02 ↑ risk of carbamazepine-induced SJS/TEN; HLAB*57:01 ↑ risk of flucoxacilline-induced liver injury; variants of FcεRIβ, STAT6, IL-4, IL-13, IL4RA and TNFα may ↑ risk of pe ...
... a drug (e.g. HLA-B*57:01 ↑ risk of abacavir hypersensitivity; HLA-B*58:01 ↑ risk of allopurinolinduced SJS/TEN/DRESS; HLA-B*15:02 ↑ risk of carbamazepine-induced SJS/TEN; HLAB*57:01 ↑ risk of flucoxacilline-induced liver injury; variants of FcεRIβ, STAT6, IL-4, IL-13, IL4RA and TNFα may ↑ risk of pe ...
Immune Notes 1 - Little Miami Schools
... -Species resistance—genetic characteristics of a species (like Homo sapiens) innately defend against certain pathogens our bodies are not suitable for certain pathogens that affect other animals ...
... -Species resistance—genetic characteristics of a species (like Homo sapiens) innately defend against certain pathogens our bodies are not suitable for certain pathogens that affect other animals ...
35 Kortylewski Nat Biotechnol 2009
... makes them an attractive new class of drugs with broad potential for the treatment of diverse human diseases. Several recent studies have shown the feasibility of in vivo siRNA delivery, demonstrating therapeutic efficacy in mouse models1–4 and nonhuman primates5,6. Nevertheless, efficient targeting ...
... makes them an attractive new class of drugs with broad potential for the treatment of diverse human diseases. Several recent studies have shown the feasibility of in vivo siRNA delivery, demonstrating therapeutic efficacy in mouse models1–4 and nonhuman primates5,6. Nevertheless, efficient targeting ...
Current Topics in Microbiology and Immunology
... Hildebrandt, the transplanted immunocompetent cells are then important for the risk of developing GVHD and for the induction of specific antileukemic reactivity. Studies in animal models and in humans suggest that chemotaxis of immunoregulatory T-cell subsets is important in the development of GVHD. ...
... Hildebrandt, the transplanted immunocompetent cells are then important for the risk of developing GVHD and for the induction of specific antileukemic reactivity. Studies in animal models and in humans suggest that chemotaxis of immunoregulatory T-cell subsets is important in the development of GVHD. ...
Normocytic Anemia
... Autoimmune hemolysis • Most common type of immune hemolysis • primary (idiopathic) • secondary – autoimmune hemolysis secondary to: • autoimmune condition (such as SLE) • infection • lymphoma or CLL ...
... Autoimmune hemolysis • Most common type of immune hemolysis • primary (idiopathic) • secondary – autoimmune hemolysis secondary to: • autoimmune condition (such as SLE) • infection • lymphoma or CLL ...
Reduced consumption of protein-rich foods follows immune
... vertebrates, insects exhibit adaptive immunity, including induced changes in feeding behavior that aid the immune system. In particular, recent studies have pointed to the importance of protein intake in mounting an immune response. In this study, we tested the hypothesis that the polyphagous caterp ...
... vertebrates, insects exhibit adaptive immunity, including induced changes in feeding behavior that aid the immune system. In particular, recent studies have pointed to the importance of protein intake in mounting an immune response. In this study, we tested the hypothesis that the polyphagous caterp ...
Antibodies Targeting Hsa and PadA Prevent Platelet - Serval
... Streptococcus gordonii and related species of oral viridans group streptococci (VGS) are common etiological agents of infective endocarditis (IE). We explored vaccination as a strategy to prevent VGS-IE, using a novel antigen-presenting system based on non-genetically modified Lactococcus lactis dis ...
... Streptococcus gordonii and related species of oral viridans group streptococci (VGS) are common etiological agents of infective endocarditis (IE). We explored vaccination as a strategy to prevent VGS-IE, using a novel antigen-presenting system based on non-genetically modified Lactococcus lactis dis ...
EBV immune evasion genes modulating CD8
... immune evasion proteins. ......................................................................................................... 47 Figure 3.1 Schematic demonstrating the method if IFN- capture. .......................................... 76 Figure 3.2 Schematic of peptide elution and mass spectro ...
... immune evasion proteins. ......................................................................................................... 47 Figure 3.1 Schematic demonstrating the method if IFN- capture. .......................................... 76 Figure 3.2 Schematic of peptide elution and mass spectro ...
Independent of IL-4 Development of Lupus in BXSB Mice Is
... Survival of IL-42/2 and wild-type BXSB mice BXSB background mice deficient in IL-4 expression and IL-41/1 and IL-41/2 littermate controls were produced by backcrossing IL-41/2 mice to the BXSB strain and then intercrossing the N7 generation. When the resulting wild-type and IL-42/2 mice were followe ...
... Survival of IL-42/2 and wild-type BXSB mice BXSB background mice deficient in IL-4 expression and IL-41/1 and IL-41/2 littermate controls were produced by backcrossing IL-41/2 mice to the BXSB strain and then intercrossing the N7 generation. When the resulting wild-type and IL-42/2 mice were followe ...
Subcellular Localization of Toll-Like Receptor 3
... Toll-like receptor (TLR)3 recognizes dsRNA and transduces signals to activate NF-B and IFN- promoter. Type I IFNs (IFN␣/) function as key cytokines in anti-viral host defense. Human fibroblasts express TLR3 on the cell surface, and anti-TLR3 mAb inhibits dsRNA-induced IFN- secretion by fibroblas ...
... Toll-like receptor (TLR)3 recognizes dsRNA and transduces signals to activate NF-B and IFN- promoter. Type I IFNs (IFN␣/) function as key cytokines in anti-viral host defense. Human fibroblasts express TLR3 on the cell surface, and anti-TLR3 mAb inhibits dsRNA-induced IFN- secretion by fibroblas ...
Autophagy Delivers Viral Antigens for MHC Class II Presentation
... MHC class II molecules generally present peptides derived from exogenous antigens after endocytosis. However, biochemical studies have revealed that MHC class II ligands are frequently derived from intracellular proteins after endogenous processing. Endogenous MHC class II antigen presentation has b ...
... MHC class II molecules generally present peptides derived from exogenous antigens after endocytosis. However, biochemical studies have revealed that MHC class II ligands are frequently derived from intracellular proteins after endogenous processing. Endogenous MHC class II antigen presentation has b ...
Stem Cell Research
... to aid to in aidthe in the development development andand screening screening of new of new drugs. drugs. ...
... to aid to in aidthe in the development development andand screening screening of new of new drugs. drugs. ...
Bacterial lipopolysaccharide stimulates bovine neutrophil production
... killing by PMN are the most effective defenses against establishment of bacterial infection. In addition to their phagocytic and bactericidal properties, PMN may play a key supportive role through secretion of cytokines during the innate immune response. We sought to determine whether bovine PMN prod ...
... killing by PMN are the most effective defenses against establishment of bacterial infection. In addition to their phagocytic and bactericidal properties, PMN may play a key supportive role through secretion of cytokines during the innate immune response. We sought to determine whether bovine PMN prod ...
Toxoplasma gondii effectors are master regulators of the
... broadly conserved across microbial species (Box 1) (recently reviewed in [9]). IL-12 in turn activates NK and T cells to secrete interferon g (IFNg) [10]. The latter activates effector mechanisms for intracellular elimination of Toxoplasma, including the activation of interferon-regulated GTPases (I ...
... broadly conserved across microbial species (Box 1) (recently reviewed in [9]). IL-12 in turn activates NK and T cells to secrete interferon g (IFNg) [10]. The latter activates effector mechanisms for intracellular elimination of Toxoplasma, including the activation of interferon-regulated GTPases (I ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.