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UNIVERSIDAD DE MURCIA FACULTAD DE VETERINARIA In vivo
... infection, both in lung and secondary lymph organs. Swine PRRSV infection has been associated with B and T cell depletion in cortical areas of secondary lymph organs as lymph nodes; which suggest an important role of these tissues in the host immunity modulation by PRRSV. Several authors have publis ...
... infection, both in lung and secondary lymph organs. Swine PRRSV infection has been associated with B and T cell depletion in cortical areas of secondary lymph organs as lymph nodes; which suggest an important role of these tissues in the host immunity modulation by PRRSV. Several authors have publis ...
Acute susceptibility of aged mice to infection with Candida albicans
... generation of oxygen radicals, after stimulation with low levels of IFN-y [29]. Hyphal growth forms of the yeast are readily susceptible to killing by neutrophils [30], and the marked increase in mycelial elements seen in the aging nonimmune mice might have reflected a quantitative or qualitative re ...
... generation of oxygen radicals, after stimulation with low levels of IFN-y [29]. Hyphal growth forms of the yeast are readily susceptible to killing by neutrophils [30], and the marked increase in mycelial elements seen in the aging nonimmune mice might have reflected a quantitative or qualitative re ...
Psoriasis - New England Journal of Medicine
... distinct entity dates back only to the year 1841, and estimates of its prevalence — around 2 percent, according to standard textbooks — stem from only a few population-based studies. Perhaps the most comprehensive field study was performed in the Faroe Islands, where 2.8 percent of the inhabitants w ...
... distinct entity dates back only to the year 1841, and estimates of its prevalence — around 2 percent, according to standard textbooks — stem from only a few population-based studies. Perhaps the most comprehensive field study was performed in the Faroe Islands, where 2.8 percent of the inhabitants w ...
Tract Infection Oviduct Pathology in Chlamydial Genital Receptor
... matis as well as its role in inflammation and the resulting pathological sequelae that occur (5–10). The relatively new discovery of the involvement of Toll-like receptors (TLRs) (11) in the innate host response has prompted investigations of these receptors as potential regulators of the response t ...
... matis as well as its role in inflammation and the resulting pathological sequelae that occur (5–10). The relatively new discovery of the involvement of Toll-like receptors (TLRs) (11) in the innate host response has prompted investigations of these receptors as potential regulators of the response t ...
Probiotics For Men’s Health CooperativeHealth Special Report 1. What Are Probiotics?
... Stomach ulcers are often caused by the bacteria Helicobacter pylori, and this is good news because there are effective ways to treat this gastrointestinal condition that includes probiotics. Research indicates that probiotics, when used along with therapies such as levofloxacin, various quinolones, ...
... Stomach ulcers are often caused by the bacteria Helicobacter pylori, and this is good news because there are effective ways to treat this gastrointestinal condition that includes probiotics. Research indicates that probiotics, when used along with therapies such as levofloxacin, various quinolones, ...
curriculum vitae
... NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction of organ-specific autoimmunity. J Leukoc Biol 69:440. 17. Kappos, L., G. Comi, H. Panitch, J. Oger, J. Antel, P. Conlon, and L. Steinman ...
... NOD macrophages are uniquely characterized by genetically programmed, elevated expression of the IL-12(p40) gene, suggesting a conserved pathway for the induction of organ-specific autoimmunity. J Leukoc Biol 69:440. 17. Kappos, L., G. Comi, H. Panitch, J. Oger, J. Antel, P. Conlon, and L. Steinman ...
IL-17/IL-17 receptor system in autoimmune disease
... examination of Il6 − / − mice revealed several innate subsets of IL-17-producing cells that arise independently of IL-6, including iNKT cells, γ δ T-cells, LTi-like cells (lymphoid-tissue inducer-like cell) and NK-like cells [11]. Another important transcriptional regulator that regulates innate IL- ...
... examination of Il6 − / − mice revealed several innate subsets of IL-17-producing cells that arise independently of IL-6, including iNKT cells, γ δ T-cells, LTi-like cells (lymphoid-tissue inducer-like cell) and NK-like cells [11]. Another important transcriptional regulator that regulates innate IL- ...
VeriPrime Bulletin: Beta Glucans
... revealed that a crude yeast cell preparation stimulated macrophages via activation of complement [13]. Further work identified the immunomodulatory active component as beta glucan [14]. Beta glucans show notable physiological effects; this is their most important quality and the reason why so much a ...
... revealed that a crude yeast cell preparation stimulated macrophages via activation of complement [13]. Further work identified the immunomodulatory active component as beta glucan [14]. Beta glucans show notable physiological effects; this is their most important quality and the reason why so much a ...
Predictors of lymph node metastasis in patients with breast cancer
... have shown that not all patients with positive SLN need a completion axillary lymph node dissection (ALND). A tailored surgical approach with careful risk-benefit assessment and aiming at high accuracy and low morbidity is becoming the guiding principle in modern management of the axilla for women w ...
... have shown that not all patients with positive SLN need a completion axillary lymph node dissection (ALND). A tailored surgical approach with careful risk-benefit assessment and aiming at high accuracy and low morbidity is becoming the guiding principle in modern management of the axilla for women w ...
Survival strategies of inside the human macrophage Mycobacterium tuberculosis Amanda Welin
... host cell occurs. However, although the bacilli activated inflammasome complexes in the host cell and IL-1β was secreted during infection of macrophages, Mtb infection did not induce either of the recently characterized inflammasome-related cell death types pyroptosis or pyronecrosis. Thus, we have ...
... host cell occurs. However, although the bacilli activated inflammasome complexes in the host cell and IL-1β was secreted during infection of macrophages, Mtb infection did not induce either of the recently characterized inflammasome-related cell death types pyroptosis or pyronecrosis. Thus, we have ...
ABSTRACT Title of Document:
... than those infected with Mtb, or cells derived from NOX2 deficient mice. NuoG also inhibited apoptosis in human alveolar macrophages in a NOX2 dependent manner. These data suggest that reduction of phagosomal ROS is important for inhibition of apoptosis. Consistent with this hypothesis, Mtb deficie ...
... than those infected with Mtb, or cells derived from NOX2 deficient mice. NuoG also inhibited apoptosis in human alveolar macrophages in a NOX2 dependent manner. These data suggest that reduction of phagosomal ROS is important for inhibition of apoptosis. Consistent with this hypothesis, Mtb deficie ...
Immunology - Department of Pathology
... All those who undertake a Research Project will have the opportunity to present their work at a day of Project Presentations starting at 10:00 am on Thursday 4 May 2017 in the Seminar Room. Details will be emailed to students closer to the date. In preparation for the “practical exam” on data handli ...
... All those who undertake a Research Project will have the opportunity to present their work at a day of Project Presentations starting at 10:00 am on Thursday 4 May 2017 in the Seminar Room. Details will be emailed to students closer to the date. In preparation for the “practical exam” on data handli ...
Kakkar-2008-The IL-33_ST2 pathwa
... member of the family, , was identified as an orphan receptor2. Investigation into the function of ST2 revealed its participation in inflammatory processes, ...
... member of the family, , was identified as an orphan receptor2. Investigation into the function of ST2 revealed its participation in inflammatory processes, ...
This costimulator is expressed by professional APCs
... The transient increase in the number of circulating neutrophils to indicate the presence of an infection is medically denoted by this name. ...
... The transient increase in the number of circulating neutrophils to indicate the presence of an infection is medically denoted by this name. ...
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by
... to cryptic sites within collagen is associated with the immunodominant epitopes found within its triple helical and noncollagenous domains. These major structural epitopes likely dominate the immune response. In fact, the majority of MAbs developed to date are directed to epitopes normally exposed w ...
... to cryptic sites within collagen is associated with the immunodominant epitopes found within its triple helical and noncollagenous domains. These major structural epitopes likely dominate the immune response. In fact, the majority of MAbs developed to date are directed to epitopes normally exposed w ...
coccidioidomycosis (valley fever): a re
... 10. The Th1 cytokine profile correlates with resistance to Coccidioides infection while the Th2 cytokine profile correlates with susceptibility. Interleukin-6 plays a key role in acute inflammation and in the differentiation of T lymphocytes into cells that secrete interleukin-17. Persistent activat ...
... 10. The Th1 cytokine profile correlates with resistance to Coccidioides infection while the Th2 cytokine profile correlates with susceptibility. Interleukin-6 plays a key role in acute inflammation and in the differentiation of T lymphocytes into cells that secrete interleukin-17. Persistent activat ...
Cystic Fibrosis Impact on Cellular Function - Carroll Collected
... among organs such as the skin, lungs, pancreas, liver, and gastrointestinal tracts, and could cause multisystem organ failure in the body (1). In people with CF, the CFTR gene is defective due to mutations, which occur on chromosome 7, and this gene then affects the protein called CFTR (1). The defe ...
... among organs such as the skin, lungs, pancreas, liver, and gastrointestinal tracts, and could cause multisystem organ failure in the body (1). In people with CF, the CFTR gene is defective due to mutations, which occur on chromosome 7, and this gene then affects the protein called CFTR (1). The defe ...
Update on allergy immunotherapy - Journal of Allergy and Clinical
... T cells (TH2-like cells) exist at a high frequency.8,9 Hence a change in the dominant subset toward IL-4 might lead to the development of allergy, whereas IL-10 dominance leads to recovery. Peripheral tolerance to allergens involves multiple suppressive factors, such as IL-10, TGF-b, cytotoxic T lym ...
... T cells (TH2-like cells) exist at a high frequency.8,9 Hence a change in the dominant subset toward IL-4 might lead to the development of allergy, whereas IL-10 dominance leads to recovery. Peripheral tolerance to allergens involves multiple suppressive factors, such as IL-10, TGF-b, cytotoxic T lym ...
Licentiate thesis from the Department of Immunology,
... estimated that a third of the world’s population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Protection mediated by BCG, against p ...
... estimated that a third of the world’s population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Protection mediated by BCG, against p ...
The Tuning Innate Immune Activation by Surface
... Address correspondence and reprint requests to Dr. Evelyn A. Kurt-Jones, Department of Medicine, University of Massachusetts Medical School, Lazare Research ...
... Address correspondence and reprint requests to Dr. Evelyn A. Kurt-Jones, Department of Medicine, University of Massachusetts Medical School, Lazare Research ...
The Tuning Innate Immune Activation by Surface
... Address correspondence and reprint requests to Dr. Evelyn A. Kurt-Jones, Department of Medicine, University of Massachusetts Medical School, Lazare Research ...
... Address correspondence and reprint requests to Dr. Evelyn A. Kurt-Jones, Department of Medicine, University of Massachusetts Medical School, Lazare Research ...
Slowing of wound healing by psychological stress
... Introduction Cellular immunity has an important role in the regulation of wound repair. Proinflammatory cytokines such as interleukin-1, interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activat ...
... Introduction Cellular immunity has an important role in the regulation of wound repair. Proinflammatory cytokines such as interleukin-1, interleukin-8, and tumour necrosis factor (TNF) help to protect against infection, prepare injured tissue for repair, and enhance phagocyte recruitment and activat ...
Protein aggregation complicates the development of baculovirus-expressed African horsesickness
... vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine strain had to be discontinued following safety problems and all subsequent attempts to prepare another AHSV5 vaccine strain by traditional attenuation procedure ...
... vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine strain had to be discontinued following safety problems and all subsequent attempts to prepare another AHSV5 vaccine strain by traditional attenuation procedure ...
Layers of the Skin
... Mast cells can trigger a local inflammatory response to antigen by releasing substances that act on blood vessels. They are particularly important in allergic responses.1 ...
... Mast cells can trigger a local inflammatory response to antigen by releasing substances that act on blood vessels. They are particularly important in allergic responses.1 ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.