Compartmentalizing intestinal epithelial cell toll
... lines. In general, TLRs recognition of PAMPs can occur in multiple cellular compartments including cell surface, endosomes, and lysosomes [26]. The proper cellular compartmentalization of TLRs appears to be critical for ligand binding, maintenance of immune tolerance, and initiation of downstream si ...
... lines. In general, TLRs recognition of PAMPs can occur in multiple cellular compartments including cell surface, endosomes, and lysosomes [26]. The proper cellular compartmentalization of TLRs appears to be critical for ligand binding, maintenance of immune tolerance, and initiation of downstream si ...
CD1d Ligands: The Good, the Bad, and the Ugly
... ␣-GalCer activity, Tsuji and colleagues (53–57) used a different approach. In their studies, they used a C-glycosidic form of ␣-GalCer in analyses of the adjuvant properties of ␣-GalCer. It was found that the C-glycoside induced more of a Th1 (i.e., IFN-␥) response, was longer lasting, and was actua ...
... ␣-GalCer activity, Tsuji and colleagues (53–57) used a different approach. In their studies, they used a C-glycosidic form of ␣-GalCer in analyses of the adjuvant properties of ␣-GalCer. It was found that the C-glycoside induced more of a Th1 (i.e., IFN-␥) response, was longer lasting, and was actua ...
A hypothesis for the initiation of COPD PERSPECTIVE
... degree of airway obstruction and emphysema are all related to increased CD8+ cells and/or CD8+/CD4+ ratio [67–69]. In resemblance to host immune response to a viral infection, CD8+ cells attack the altered LEBCs and perform cytotoxic functions, activating cell death cascades [20, 26, 37]. In agreeme ...
... degree of airway obstruction and emphysema are all related to increased CD8+ cells and/or CD8+/CD4+ ratio [67–69]. In resemblance to host immune response to a viral infection, CD8+ cells attack the altered LEBCs and perform cytotoxic functions, activating cell death cascades [20, 26, 37]. In agreeme ...
Sex hormone modulation of human uterine epithelial cell immune
... discomfort to death. The female reproductive tract has evolved innate and adaptive immune mechanisms that protect from microbial infection, thereby reducing infection and disease. Central to this protection are the epithelial cells that line the female reproductive tract. In the uterus, columnar epi ...
... discomfort to death. The female reproductive tract has evolved innate and adaptive immune mechanisms that protect from microbial infection, thereby reducing infection and disease. Central to this protection are the epithelial cells that line the female reproductive tract. In the uterus, columnar epi ...
17-transplantation
... Recipient T-cells are activated by recipient MHC + graft (MHC) peptides Analogous to normal T-cell response to pathogens (or vaccines) Recipient DCs migrate into graft and phagocytose Ags -- fewer T-cells respond (most AG being ‘self’) but among these will also be… -- MHC peptides -- Minor Histocomp ...
... Recipient T-cells are activated by recipient MHC + graft (MHC) peptides Analogous to normal T-cell response to pathogens (or vaccines) Recipient DCs migrate into graft and phagocytose Ags -- fewer T-cells respond (most AG being ‘self’) but among these will also be… -- MHC peptides -- Minor Histocomp ...
2016 Poster Listing
... Adrielle Veloso Caixeta, 4020, Characterization of the antitumor and immunomodulatory properties of new HDAC inhibitors as targeted anti-cancer drugs Alistair Cook, 1400, Tumour resection in patients with non-small cell lung cancer does not modulate the adaptive immune system in a systemic manner Am ...
... Adrielle Veloso Caixeta, 4020, Characterization of the antitumor and immunomodulatory properties of new HDAC inhibitors as targeted anti-cancer drugs Alistair Cook, 1400, Tumour resection in patients with non-small cell lung cancer does not modulate the adaptive immune system in a systemic manner Am ...
Factors affecting the antigen-antibody reaction (PDF
... in the conformational flexibility of the antigen binding site of the antibody25. The whole process can be described in this way: B-cell antigen receptors are able to recognise an enormous repertoire of different antigens because their binding sites cross-react with a variety of antigens and the acti ...
... in the conformational flexibility of the antigen binding site of the antibody25. The whole process can be described in this way: B-cell antigen receptors are able to recognise an enormous repertoire of different antigens because their binding sites cross-react with a variety of antigens and the acti ...
neuroimmunology - Dr. Amr Hasan Neurology Clinic
... The complement system is a group of heat-labile proteins produced by the liver normally found in blood and tissue fluids (except urine and CSF). ...
... The complement system is a group of heat-labile proteins produced by the liver normally found in blood and tissue fluids (except urine and CSF). ...
Infectious agents and cancer: criteria for a causal - UNC
... develop in patients with congenital immune impairment including the X-linked lymphoproliferative syndrome, severe combined immunodeficiency, adenosine deaminase deficiency, and Wiscott-Aldrich syndrome and especially in organ-transplant recipients and patients with AIDS. In addition to these key bio ...
... develop in patients with congenital immune impairment including the X-linked lymphoproliferative syndrome, severe combined immunodeficiency, adenosine deaminase deficiency, and Wiscott-Aldrich syndrome and especially in organ-transplant recipients and patients with AIDS. In addition to these key bio ...
secondary immunological lysis in ehrlich`s ascites carcinoma
... the injection of ink can be said to have called forth a non-specific inflammatory response. At the same time the volume of fluid produced in the males in response to tumour was no greater than that produced in response to ink. This suggests that in this case the tumour cells behaved as a non-specifi ...
... the injection of ink can be said to have called forth a non-specific inflammatory response. At the same time the volume of fluid produced in the males in response to tumour was no greater than that produced in response to ink. This suggests that in this case the tumour cells behaved as a non-specifi ...
Stem Cells EBC
... • These extracts and their down stream cell products (such as interleukins and interferons) control all phases of maturation, development, antigen commitment, proliferation and cytotoxic activity of the various T cells. ...
... • These extracts and their down stream cell products (such as interleukins and interferons) control all phases of maturation, development, antigen commitment, proliferation and cytotoxic activity of the various T cells. ...
document
... Produce aplastic anaemia through their effects on actively dividing cells Timing and duration of aplasia dependent on dose Chronic/excessive exposure may result in severe/fatal aplastic anaemia Drugs and Chemicals: 1) Agents regularly producing marrow aplasia e.g. cytotoxic drugs, benzene Ef ...
... Produce aplastic anaemia through their effects on actively dividing cells Timing and duration of aplasia dependent on dose Chronic/excessive exposure may result in severe/fatal aplastic anaemia Drugs and Chemicals: 1) Agents regularly producing marrow aplasia e.g. cytotoxic drugs, benzene Ef ...
Hematopoietic Function Hematopoietic Function
... The blood-forming population of bone marrow is made up of three types of cells: self-renewing stem cells, differentiated progenitor (parent) cells, and functional mature blood cells. All of the blood cell precursors of the erythrocyte (i.e., red cell), myelocyte (i.e., granulocyte or monocyte), lymp ...
... The blood-forming population of bone marrow is made up of three types of cells: self-renewing stem cells, differentiated progenitor (parent) cells, and functional mature blood cells. All of the blood cell precursors of the erythrocyte (i.e., red cell), myelocyte (i.e., granulocyte or monocyte), lymp ...
functions occur only through constant mutualism with the INTRODUCTION
... ingestion of drugs (e.g., antibiotics, vaccines), during clinical treatments, by improving sanitation, by food composition, and by other environmental factors. Limited contact with microorganisms from the external environment defines what has been called the “hygiene hypothesis” (Strachan, 2000). Th ...
... ingestion of drugs (e.g., antibiotics, vaccines), during clinical treatments, by improving sanitation, by food composition, and by other environmental factors. Limited contact with microorganisms from the external environment defines what has been called the “hygiene hypothesis” (Strachan, 2000). Th ...
Dermatrust report, March 2013 During last year my research has
... have collected samples pre and post vaccination in order to investigate changes in cutaneous responses as a consequence of vaccination. Samples are collected for transcriptional analysis (again both saline and VZV injected skin, at 6 and 72 hours post injection from each individual) as well as histo ...
... have collected samples pre and post vaccination in order to investigate changes in cutaneous responses as a consequence of vaccination. Samples are collected for transcriptional analysis (again both saline and VZV injected skin, at 6 and 72 hours post injection from each individual) as well as histo ...
Characterization of a surface antigen of Type="Italic
... E. nieschulzi sporozoites, we conclude that mcab 3C3 recognizes a surface antigen on these organisms. This was also confirmed by immunoprecipitation data, since mcab 3C3 immunoprecipitates a radioactive protein comigrating with polypeptide found by iodinating sporozoites via the lactoperoxidase proc ...
... E. nieschulzi sporozoites, we conclude that mcab 3C3 recognizes a surface antigen on these organisms. This was also confirmed by immunoprecipitation data, since mcab 3C3 immunoprecipitates a radioactive protein comigrating with polypeptide found by iodinating sporozoites via the lactoperoxidase proc ...
Five Prime Therapeutics, Inc.
... © 2016 Five Prime Therapeutics, Inc. All Rights Reserved CD80-Fc Was Originally Identified as One of the Most Potent Agonists in Our In Vivo Screen CD80-Fc was one of most potent agonists in the in vivo screen of over 500 proteins 0 100 200 300 400 Individual Proteins Screened Potential agonist hit ...
... © 2016 Five Prime Therapeutics, Inc. All Rights Reserved CD80-Fc Was Originally Identified as One of the Most Potent Agonists in Our In Vivo Screen CD80-Fc was one of most potent agonists in the in vivo screen of over 500 proteins 0 100 200 300 400 Individual Proteins Screened Potential agonist hit ...
Notes
... • Antibiotics should only be used if necessary, and only if they will be effective against a pathogen that is susceptible to the antibiotic. • Antibiotics should only be used if alternative measures (including vaccinations, health management plans, biosecurity, etc.) are not enough to prevent and/or ...
... • Antibiotics should only be used if necessary, and only if they will be effective against a pathogen that is susceptible to the antibiotic. • Antibiotics should only be used if alternative measures (including vaccinations, health management plans, biosecurity, etc.) are not enough to prevent and/or ...
GLIIFCA 21 September 28
... Cross Platform Solutions for Autophagy Detection using the Guava 8HT and Amnis ImageStream MarkII Matthew Hsu R&D Director, EMD Millipore Autophagyis an intracellular catabolic pathway which causes cellular protein and organelle turnover, and is associated with diverse diseases such as Alzheimer’s d ...
... Cross Platform Solutions for Autophagy Detection using the Guava 8HT and Amnis ImageStream MarkII Matthew Hsu R&D Director, EMD Millipore Autophagyis an intracellular catabolic pathway which causes cellular protein and organelle turnover, and is associated with diverse diseases such as Alzheimer’s d ...
i. introduction
... or the bursa of Fabricius. The function of these organs was understood in the sixties and early seventies, decades after he published his seminal papers on stress. With the advent of the science of Immunology it became clear that stress has a profound immunosuppressive effect and increases the susce ...
... or the bursa of Fabricius. The function of these organs was understood in the sixties and early seventies, decades after he published his seminal papers on stress. With the advent of the science of Immunology it became clear that stress has a profound immunosuppressive effect and increases the susce ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.