Chlorella vulgaris restores bone marrow cellularity and cytokine
... to produce cytokines, particularly IFN-c. Relative to IFNs, it is well demonstrated that IFN or IFN-inducers potentiate NK cell reactivity (Justo et al., 2003; Queiroz et al., 2002; Zwirner and Domaica, 2010), thus favoring Th1-type responses. In this regard, previous studies from our laboratory and ...
... to produce cytokines, particularly IFN-c. Relative to IFNs, it is well demonstrated that IFN or IFN-inducers potentiate NK cell reactivity (Justo et al., 2003; Queiroz et al., 2002; Zwirner and Domaica, 2010), thus favoring Th1-type responses. In this regard, previous studies from our laboratory and ...
Cytotoxic immunological synapses Michael L. Dustin Eric O. Long
... Inhibitory NK cell synapses NK cells look similar to T lymphocytes but lack antigen receptors and instead express an array of activating and inhibitory receptors and the Fc receptor CD16. Most host cells are protected from NK cells by expressing MHC–peptide complexes on their surface. In mice, these ...
... Inhibitory NK cell synapses NK cells look similar to T lymphocytes but lack antigen receptors and instead express an array of activating and inhibitory receptors and the Fc receptor CD16. Most host cells are protected from NK cells by expressing MHC–peptide complexes on their surface. In mice, these ...
Immunogenetics: changing the face of immunodeficiency
... that boys aVected by XHM were susceptible to opportunistic infection with organisms such as Pneumocystis carinii.14 More recently, particular susceptibility to Cryptosporidium parvum has also been recognised. It was therefore not surprising when the gene responsible for XHM was identified in 1993 as ...
... that boys aVected by XHM were susceptible to opportunistic infection with organisms such as Pneumocystis carinii.14 More recently, particular susceptibility to Cryptosporidium parvum has also been recognised. It was therefore not surprising when the gene responsible for XHM was identified in 1993 as ...
... inflammation, the additional appearance of oxygen radicals from any source may lead to prolonged and additive inflammatory effects, mediated in part through the transcription factor NF-κB. How this synergistic effect is mediated, remains unknown. The variations of the effect of the different agents ...
The role of gut-associated lymphoid tissues and mucosal defence
... & Goodman, 1989), compared to specific pathogen-free or germfree mice colonized with single or multiple species of bacteria. A recent study using gnotobiotic rats showed that under germfree conditions, the follicle-associated epithelium (FAE) contains only a few T and B cells and the B cells were ne ...
... & Goodman, 1989), compared to specific pathogen-free or germfree mice colonized with single or multiple species of bacteria. A recent study using gnotobiotic rats showed that under germfree conditions, the follicle-associated epithelium (FAE) contains only a few T and B cells and the B cells were ne ...
Key Words: Heavy exercise, Red blood cells, Immune function
... three durations; 15, 30 or 45 min, the activities of red blood cell CR1 in healthy young males markedly decreased immediately and 3 hours post-exercise, and recovered 15 hours post-exercise. However, no distinct change in the rosette formation rate of red blood cell CR1 occurred immediately after a ...
... three durations; 15, 30 or 45 min, the activities of red blood cell CR1 in healthy young males markedly decreased immediately and 3 hours post-exercise, and recovered 15 hours post-exercise. However, no distinct change in the rosette formation rate of red blood cell CR1 occurred immediately after a ...
The role of lactate on the immunomodulatory properties of the
... intestinal-trefoil factor (ITF) and macrophage-migration-inhibitory factor (MIF) were assayed as described by Romanin et al. (2010); while expression of the gene encoding the G-protein-coupled receptor 81 (GPR81) in Caco-2-ccl20:luc, AGS, and human-small-intestine and colon cells was detected throug ...
... intestinal-trefoil factor (ITF) and macrophage-migration-inhibitory factor (MIF) were assayed as described by Romanin et al. (2010); while expression of the gene encoding the G-protein-coupled receptor 81 (GPR81) in Caco-2-ccl20:luc, AGS, and human-small-intestine and colon cells was detected throug ...
ZO 1819 - PHYLOGENY OF INVERTEBRATA AND CHORDATA
... DNA replication, repair and recombination: Unit of replication, enzymes involved, replication origin and replication fork, extrachromosomal replicons, DNA damage and repair mechanisms. RNA synthesis and processing: Transcription factors and machinery, formation of initiation complex, transcription a ...
... DNA replication, repair and recombination: Unit of replication, enzymes involved, replication origin and replication fork, extrachromosomal replicons, DNA damage and repair mechanisms. RNA synthesis and processing: Transcription factors and machinery, formation of initiation complex, transcription a ...
Memorizing innate instructions requires a sufficiently specific
... The ef®cient elimination of different types of pathogens requires qualitatively different immune responses, varying from cellular to humoral responses, and varying in, for example, immunoglobulin isotype and cytokine expression (1,2). During primary pathogen encounter, the innate immune system plays ...
... The ef®cient elimination of different types of pathogens requires qualitatively different immune responses, varying from cellular to humoral responses, and varying in, for example, immunoglobulin isotype and cytokine expression (1,2). During primary pathogen encounter, the innate immune system plays ...
Here is the Original File - University of New Hampshire
... • Medical product administered to stimulate the body’s immune system in order to prevent or control an infection • Therapeutic-Designed to boost body’s immune response to better control an infection[5] • Preventative-Designed to protect people from initial infection[6] ...
... • Medical product administered to stimulate the body’s immune system in order to prevent or control an infection • Therapeutic-Designed to boost body’s immune response to better control an infection[5] • Preventative-Designed to protect people from initial infection[6] ...
Apoptosis in mouse J774 macrophages-a methodological study
... levels of free radicals in the cell. Free radicals are highly reactive molecules which are formed during different kinds of biochemical reaction take place in the cell. Many scavengers molecules also known as antioxidants which are found in the cell are engaged to eliminate these free radicals. This ...
... levels of free radicals in the cell. Free radicals are highly reactive molecules which are formed during different kinds of biochemical reaction take place in the cell. Many scavengers molecules also known as antioxidants which are found in the cell are engaged to eliminate these free radicals. This ...
PDF
... reduces the likelihood that unstained cells will be mistakenly assigned, which is a possibility when only one component of the chimaera is positively identified. Cell-autonomous expression (that is, expression in chimaeric tissue strictly according to cellular genotype) might be expected of transpla ...
... reduces the likelihood that unstained cells will be mistakenly assigned, which is a possibility when only one component of the chimaera is positively identified. Cell-autonomous expression (that is, expression in chimaeric tissue strictly according to cellular genotype) might be expected of transpla ...
Biol 155 Human Physiology - Department of Zoology, UBC
... Organized in cortex and medulla Substances removed by phagocytosis or stimulate lymphocytes or both Only structures to filter lymph ...
... Organized in cortex and medulla Substances removed by phagocytosis or stimulate lymphocytes or both Only structures to filter lymph ...
Mesenchymal Stem Cells for the Treatment of Arthritis
... -Significant improvement in short form QoL in both groups -No difference in groups clinical outcomes except in physical role functioning which was better in BMSC group -No difference in groups for knee evaluation form, Lysholm knee scale and Tegner activity level scale -Under 45 year old patients di ...
... -Significant improvement in short form QoL in both groups -No difference in groups clinical outcomes except in physical role functioning which was better in BMSC group -No difference in groups for knee evaluation form, Lysholm knee scale and Tegner activity level scale -Under 45 year old patients di ...
Sickle-Cell Anemia
... Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. ...
... Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. ...
Head and Neck Cancer Awareness Month April 2016 Newsletter
... Human Papillomavirus (HPV) Research indicates that infection with this virus is becoming an increasingly common risk factor for some types of head and neck cancer. HPV is most often passed from person to person during sexual activity. There are different types, or strains, of HPV. Some strains are m ...
... Human Papillomavirus (HPV) Research indicates that infection with this virus is becoming an increasingly common risk factor for some types of head and neck cancer. HPV is most often passed from person to person during sexual activity. There are different types, or strains, of HPV. Some strains are m ...
B Lymphocytes Provide an Infection Niche for Intracellular Bacterium
... Aldrich) and postfixed in 1% osmium tetroxide in PBSsucrose for 30 minutes at 22°C and dehydrated in a graded ethanol series (30%, 50%, 70%, 80%, 95%, and 100%). Then the samples were changed to 100% dry acetone, infiltrated, and embedded with Spurr’s epoxy resin (Electron Microscopy Sciences). Sectio ...
... Aldrich) and postfixed in 1% osmium tetroxide in PBSsucrose for 30 minutes at 22°C and dehydrated in a graded ethanol series (30%, 50%, 70%, 80%, 95%, and 100%). Then the samples were changed to 100% dry acetone, infiltrated, and embedded with Spurr’s epoxy resin (Electron Microscopy Sciences). Sectio ...
Immunogenicity of Bovine and Leporine Articular Chondrocytes and
... tissue engineering strategies, small animal models such as the leporine model are commonly employed. Many studies report little to no immune rejection upon allogeneic or xenogeneic implantation of native articular and meniscal cartilages. This study investigated whether bovine and leporine articular ...
... tissue engineering strategies, small animal models such as the leporine model are commonly employed. Many studies report little to no immune rejection upon allogeneic or xenogeneic implantation of native articular and meniscal cartilages. This study investigated whether bovine and leporine articular ...
Molecular Cell Biology Prof. D. Karunagaran Department of
... Antibodies remove bacteria, inactivate bacterial toxins ...
... Antibodies remove bacteria, inactivate bacterial toxins ...
Vaccines
... system will activate a certain number of cells called B-cells. These B-cells will multiply and some of them will produce antibodies. Others of these multiplying B-cells will become memory cells. Memory B-cells can last for decades in our bodies and are able to make antibody whenever the microorganis ...
... system will activate a certain number of cells called B-cells. These B-cells will multiply and some of them will produce antibodies. Others of these multiplying B-cells will become memory cells. Memory B-cells can last for decades in our bodies and are able to make antibody whenever the microorganis ...
Genome Editing-Based HIV Therapies
... CCR5 is the major current focus because naturally existing CCR5 d32 confers resistance to HIV infection, Production of HIV-resistant cells with an artificial CCR5 mutation and reinfusing the cells into patients to confer HIV resistance is the most ...
... CCR5 is the major current focus because naturally existing CCR5 d32 confers resistance to HIV infection, Production of HIV-resistant cells with an artificial CCR5 mutation and reinfusing the cells into patients to confer HIV resistance is the most ...
Klin immunology_1
... 44. A woman of 36 years is on the 12-th week of the first pregnancy. We know from the history that she was treated for infertility. She visited friends and contacted with child who developed rubella in 2 days after meeting. Woman doesn’t know if she has ever been infected with rubella. What is the ...
... 44. A woman of 36 years is on the 12-th week of the first pregnancy. We know from the history that she was treated for infertility. She visited friends and contacted with child who developed rubella in 2 days after meeting. Woman doesn’t know if she has ever been infected with rubella. What is the ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.