lwwus_ijg_jog-d-14-00286 59..61 - MyWeb
... with retinal ganglion cells. In this image of a flat-mounted retina of a human donor with advanced glaucoma, profound labeling is observed in distinct regions. Other retinal regions of the same eye exhibit far fewer MAC-positive cells or none at all. MAC indicates membrane attack complex. ...
... with retinal ganglion cells. In this image of a flat-mounted retina of a human donor with advanced glaucoma, profound labeling is observed in distinct regions. Other retinal regions of the same eye exhibit far fewer MAC-positive cells or none at all. MAC indicates membrane attack complex. ...
MINI-SERIES ‘‘T-CELL CO-STIMULATORY MOLECULES’’ Edited by M. Belvisi and K.F. Rabe
... MIGRATION IN ALLERGIC AIRWAY INFLAMMATION The differentiation of T-cell function depends upon the recognition of a specific peptide presented by antigenpresenting cells (APCs) in combination with additional costimulatory signals, as described in the first article in the present series [64]. In recen ...
... MIGRATION IN ALLERGIC AIRWAY INFLAMMATION The differentiation of T-cell function depends upon the recognition of a specific peptide presented by antigenpresenting cells (APCs) in combination with additional costimulatory signals, as described in the first article in the present series [64]. In recen ...
Vaccine development strategies Plasmodium falciparum
... secreting antibodies. Antibodies constitute the main specific operator against extracellular pathogens and toxins, and are divided into five classes or isotypes: IgD, IgM, IgE, IgA and IgG. IgA and IgG are further divided into the subclasses IgA1 and IgA2, and IgG1, -2, -3 and -4, respectively. IgD ...
... secreting antibodies. Antibodies constitute the main specific operator against extracellular pathogens and toxins, and are divided into five classes or isotypes: IgD, IgM, IgE, IgA and IgG. IgA and IgG are further divided into the subclasses IgA1 and IgA2, and IgG1, -2, -3 and -4, respectively. IgD ...
Structured illumination microscopy reveals novel insights into
... popular model suggests that the branched actin network comprising the dSMAC, which is created by Arp2/3-dependent nucleation, is converted into the concentric arcs by debranching and crosslinking. In contrast to this idea, we observed linear actin filaments that arise at the plasma membrane and proj ...
... popular model suggests that the branched actin network comprising the dSMAC, which is created by Arp2/3-dependent nucleation, is converted into the concentric arcs by debranching and crosslinking. In contrast to this idea, we observed linear actin filaments that arise at the plasma membrane and proj ...
Exploring the reciprocal relationship between
... Experimental models seeking to explore how susceptible individuals develop rheumatoid arthritis (RA) propose that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. T lymphocytes and MHC class II genes have feat ...
... Experimental models seeking to explore how susceptible individuals develop rheumatoid arthritis (RA) propose that genetic and environmental factors shape a complex series of molecular and cellular interactions leading to a chronic inflammatory response. T lymphocytes and MHC class II genes have feat ...
Dendritic Cell Biology - Wiley-VCH
... In transplantation, we need to understand more about the initiation of immunity, i.e. what processes in the graft allow dendritic cells to initiate immunity both by the direct pathway (graft dendritic cells present antigens to host T cells) and indirect pathway (host dendritic cells present antigens ...
... In transplantation, we need to understand more about the initiation of immunity, i.e. what processes in the graft allow dendritic cells to initiate immunity both by the direct pathway (graft dendritic cells present antigens to host T cells) and indirect pathway (host dendritic cells present antigens ...
Autoimmunity and pulmonary hypertension: a perspective REVIEW
... progression of this disease [38]. An instigating injury to endothelial cells in scleroderma that may trigger such auto-antibody formation may be viral infection [39]. A number of investigators have found evidence for viral infections, such as Epstein-Barr virus, parvovirus B19 and hepatitis C, E, an ...
... progression of this disease [38]. An instigating injury to endothelial cells in scleroderma that may trigger such auto-antibody formation may be viral infection [39]. A number of investigators have found evidence for viral infections, such as Epstein-Barr virus, parvovirus B19 and hepatitis C, E, an ...
Tracking antigen specific T cell dynamics in vivo
... CD28 very important (IL-2 needed) IL-2 important IL-2 knockouts lethal lymphoproliferation Treg wanabees are there but need IL-2 added back to function as regs IL-2 alpha and beta receptor chain knockouts ...
... CD28 very important (IL-2 needed) IL-2 important IL-2 knockouts lethal lymphoproliferation Treg wanabees are there but need IL-2 added back to function as regs IL-2 alpha and beta receptor chain knockouts ...
IHIM, STELLA AMARACHI - It works
... also increased the emphasis on the role of the immune system in defending individuals against infections. The two mechanisms of the immune system can be modified by substances to either enhance or suppress their ability to resist invasion by pathogens (William, 2001). There are however, limited stra ...
... also increased the emphasis on the role of the immune system in defending individuals against infections. The two mechanisms of the immune system can be modified by substances to either enhance or suppress their ability to resist invasion by pathogens (William, 2001). There are however, limited stra ...
Pivotal Role of the B7:CD28 Pathway in
... ' (eg, endothelium) can also present antigen under certain condition^.**^*^ Three distinct stages of cell-cell interaction between APCs and antigen-specificT cells are required to induce an antigenspecific immune response. Figure 1 depicts the known cell interaction molecules that are responsible fo ...
... ' (eg, endothelium) can also present antigen under certain condition^.**^*^ Three distinct stages of cell-cell interaction between APCs and antigen-specificT cells are required to induce an antigenspecific immune response. Figure 1 depicts the known cell interaction molecules that are responsible fo ...
Etiology - the Museum of Health Care!
... Dendritic cells are a key part of the mammalian immune system. They are present in our bodies where our tissues are in contact with the external environment, such as the skin and the lung alveolae. When dendritic cells detect foreign substances entering the body, they engulf them, process them into ...
... Dendritic cells are a key part of the mammalian immune system. They are present in our bodies where our tissues are in contact with the external environment, such as the skin and the lung alveolae. When dendritic cells detect foreign substances entering the body, they engulf them, process them into ...
T cell receptor-transgenic mouse models for studying cellular
... adoptive transfer of a few TCR-transgenic T cells to syngenic non-transgenic recipient mice is generally being used to obtain a small (0.2^1%) but detectable population of naive CD4þ T cells that can be tracked in vivo during induction using clonotypic monoclonal antibodies [7], MHC-II tetramers [8] ...
... adoptive transfer of a few TCR-transgenic T cells to syngenic non-transgenic recipient mice is generally being used to obtain a small (0.2^1%) but detectable population of naive CD4þ T cells that can be tracked in vivo during induction using clonotypic monoclonal antibodies [7], MHC-II tetramers [8] ...
Small proportion have immune defect
... presented by Class 1 or Class 2 molecules. Class 1 and Class 2 molecules reside on the surface of antigen-presenting cells such as macrophages, dendritic cells and B cells. This is followed by negative selection, whereby T cells which have an excessively high affinity for self Class 1 and Class 2 mo ...
... presented by Class 1 or Class 2 molecules. Class 1 and Class 2 molecules reside on the surface of antigen-presenting cells such as macrophages, dendritic cells and B cells. This is followed by negative selection, whereby T cells which have an excessively high affinity for self Class 1 and Class 2 mo ...
Clinical Case Conference
... Side effects of ATG Fever and chills during the initial ATG infusion Anaphylactic reactions, including respiratory distress and ...
... Side effects of ATG Fever and chills during the initial ATG infusion Anaphylactic reactions, including respiratory distress and ...
Dissecting the human immunologic memory for pathogens
... switch, and affinity maturation of antigen-specific B cells, leading to the generation of memory B cells and long-lived plasma cells that produce high affinity somatically mutated antibodies of switched isotypes (17). The GC reaction is driven by persisting antigen on the surface of follicular dendr ...
... switch, and affinity maturation of antigen-specific B cells, leading to the generation of memory B cells and long-lived plasma cells that produce high affinity somatically mutated antibodies of switched isotypes (17). The GC reaction is driven by persisting antigen on the surface of follicular dendr ...
Invest Ophthalmol Vis Sci 1999 - Weizmann Institute of Science
... PURPOSE. Idiopathic inflammation of the cornea, keratitis, has been proposed to result from an autoimmune process, but thus far no convenient animal model of keratitis exists. An attempt was made to establish an animal model for keratitis, to investigate possible autoimmune mechanisms. METHODS. T-ce ...
... PURPOSE. Idiopathic inflammation of the cornea, keratitis, has been proposed to result from an autoimmune process, but thus far no convenient animal model of keratitis exists. An attempt was made to establish an animal model for keratitis, to investigate possible autoimmune mechanisms. METHODS. T-ce ...
Phage Display and its Applications
... selected antigens as a regular polypeptide phage. One example of this besides using magnetic beads is affinity chromatography (separation of biochemical solutions) If a solution known to contain antibodies against a specific antigen, then the phage expressing specific antigen can be isolated by sele ...
... selected antigens as a regular polypeptide phage. One example of this besides using magnetic beads is affinity chromatography (separation of biochemical solutions) If a solution known to contain antibodies against a specific antigen, then the phage expressing specific antigen can be isolated by sele ...
McSorley 2013 IJP - Rick Maizels` Group
... As mentioned above, many of the suppressive functions of parasite products are heat-stable, indicating they may be of carbohydrate nature. Elucidation of immunomodulatory carbohydrates from helminths has been hindered by a lack of tools for identification, manipulation and production of these molecul ...
... As mentioned above, many of the suppressive functions of parasite products are heat-stable, indicating they may be of carbohydrate nature. Elucidation of immunomodulatory carbohydrates from helminths has been hindered by a lack of tools for identification, manipulation and production of these molecul ...
LDN - Meridian Kinesiology
... Recent Clinical Studies on Safety and Benefits of LDN for Autoimmune Diseases Although the video above makes it seem as though there are virtually no scientific inquiries into the safety and benefits of LDN, that’s not an entirely accurate assessment. Several studies have been conducted, and more ar ...
... Recent Clinical Studies on Safety and Benefits of LDN for Autoimmune Diseases Although the video above makes it seem as though there are virtually no scientific inquiries into the safety and benefits of LDN, that’s not an entirely accurate assessment. Several studies have been conducted, and more ar ...
Interaction between tumour-infiltrating B cells and T cells controls
... shown to play a critical role in controlling tumour progression.3 Studies in many human cancers, including HCC, demonstrated a positive correlation between the density of T cells and better patient prognosis.4 On the other hand, the involvement of B cells in cancer development and progression is rat ...
... shown to play a critical role in controlling tumour progression.3 Studies in many human cancers, including HCC, demonstrated a positive correlation between the density of T cells and better patient prognosis.4 On the other hand, the involvement of B cells in cancer development and progression is rat ...
11 Preventing cancer
... Lung cancer is a rare diseas except amongs mokers. Exposure to side stream cigarettes moke ecreases the risk for nonsmokers. Lung tissue damage and cellular changes that precede lung cancer have been observed in 93 percent of active smokers but in only 6 percent of exsmokers and 1 percent of nonsmok ...
... Lung cancer is a rare diseas except amongs mokers. Exposure to side stream cigarettes moke ecreases the risk for nonsmokers. Lung tissue damage and cellular changes that precede lung cancer have been observed in 93 percent of active smokers but in only 6 percent of exsmokers and 1 percent of nonsmok ...
Influence of Linex and Enterosgel on humoral immunity in patients
... capable of neutralizing bacterial toxins, viruses, eliminate antigens entering mucosa of the intestinal lumen as well as stimulate phagocytosis by providing local immunity. The fact that IgA does not activate the complement system, minimizes the inflammatory component in performance of immune mechan ...
... capable of neutralizing bacterial toxins, viruses, eliminate antigens entering mucosa of the intestinal lumen as well as stimulate phagocytosis by providing local immunity. The fact that IgA does not activate the complement system, minimizes the inflammatory component in performance of immune mechan ...
Different Nuclear Signals Are Activated by the B Cell
... than 250 cells (bold solid line) and tracings from two single cells (dashed and dotted lines). Data are representative of three experiments. (C) The distribution of mean basal [Ca21]i in single cells. (Left) The distribution of calcium means in freshly isolated naive (dashed line) and tolerant (soli ...
... than 250 cells (bold solid line) and tracings from two single cells (dashed and dotted lines). Data are representative of three experiments. (C) The distribution of mean basal [Ca21]i in single cells. (Left) The distribution of calcium means in freshly isolated naive (dashed line) and tolerant (soli ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.