Programmed cell death, autophagy, autohagic cell death
... 27. System level analysis of the cell death network by single and double RNAimediated perturbations (Zalckvar E) Interaction of apoptosis and autophagy pathways 28. role of autophagy in caspase-independent cell death (Lenardo MJ) 29. System level analysis of programmed cell death: switching between ...
... 27. System level analysis of the cell death network by single and double RNAimediated perturbations (Zalckvar E) Interaction of apoptosis and autophagy pathways 28. role of autophagy in caspase-independent cell death (Lenardo MJ) 29. System level analysis of programmed cell death: switching between ...
Principal Investigator/Program Director (Last, First, Middle): Halonen
... Type: Fellowship Award Funding Period: 09/01/14-05/15/18 Major Goal: Neural Stem Cells (NSCs) are partially differentiated pluripotent stem cells that have the ability to generate all types of cells found in the central nervous system (CNS). NSCs derived differentiated cells will be used to generate ...
... Type: Fellowship Award Funding Period: 09/01/14-05/15/18 Major Goal: Neural Stem Cells (NSCs) are partially differentiated pluripotent stem cells that have the ability to generate all types of cells found in the central nervous system (CNS). NSCs derived differentiated cells will be used to generate ...
The Role of Interleukin-6 in the Febrile Response Namik Hamzic
... Previous studies from our group have provided evidence in support of the existence of a pathway across the blood-brain barrier by demonstrating that proinflammatory cytokine interleukin-1 transfers the inflammatory message to the brain through binding to its receptors situated in the brain vessels. ...
... Previous studies from our group have provided evidence in support of the existence of a pathway across the blood-brain barrier by demonstrating that proinflammatory cytokine interleukin-1 transfers the inflammatory message to the brain through binding to its receptors situated in the brain vessels. ...
Figure Legends - Institute of Cancer Research
... Resc(LCΔex5) flies that lack rLC isoforms displayed significantly stronger IMD pathway activation after injection of polymeric PGN, while the response to TCT was unchanged (Fig. 2f). Next, we engineered flies carrying all possible permutations of activating isoforms LCx and LCa and regulatory isofor ...
... Resc(LCΔex5) flies that lack rLC isoforms displayed significantly stronger IMD pathway activation after injection of polymeric PGN, while the response to TCT was unchanged (Fig. 2f). Next, we engineered flies carrying all possible permutations of activating isoforms LCx and LCa and regulatory isofor ...
Protein aggregation complicates the development of baculovirus-expressed African horsesickness
... & Taylor 1991 ). Nevertheless, all the remaining neurotropic cell culture-produced vaccine strains were subsequently replaced with fully cell culture-attenuated vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine ...
... & Taylor 1991 ). Nevertheless, all the remaining neurotropic cell culture-produced vaccine strains were subsequently replaced with fully cell culture-attenuated vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine ...
Critical Review A role for anti-HSP60 antibodies in arthritis: a critical review
... Figure 2: Immunological interactions triggered by HSP60 biology. Cellular stress can be triggered by external changes in pH, O2, from the presence of oxygen radicals, toxic metabolites from inflammation and the recognition of pathogen-associated molecular patterns (PAMPs) through toll-like receptor ...
... Figure 2: Immunological interactions triggered by HSP60 biology. Cellular stress can be triggered by external changes in pH, O2, from the presence of oxygen radicals, toxic metabolites from inflammation and the recognition of pathogen-associated molecular patterns (PAMPs) through toll-like receptor ...
SERIES "INFECTION: FRIEND OR FOE TO THE DEVELOPMENT OF ASTHMA?"
... infections [41–44]. Patients with scarring sequelae of repeated/persistent C. trachomatis infection have been found to have a depressed cell-mediated immune response, indicated by decreased interferon (IFN)-c levels and increased antibody levels as compared with age- and sex-matched controls, sugges ...
... infections [41–44]. Patients with scarring sequelae of repeated/persistent C. trachomatis infection have been found to have a depressed cell-mediated immune response, indicated by decreased interferon (IFN)-c levels and increased antibody levels as compared with age- and sex-matched controls, sugges ...
Homeostasis of the gut barrier and potential biomarkers
... role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of secretory IgA (sIgA) and antimicrobial peptides and proteins. With the exception of sIgA, expression of these protective barrier factors is largely controlled by ...
... role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of secretory IgA (sIgA) and antimicrobial peptides and proteins. With the exception of sIgA, expression of these protective barrier factors is largely controlled by ...
Our focus is on vaccines
... • Chimigen® HIV Vaccine is immunogenic; most of the animals responded • Chimigen® HIV Vaccine is capable of inducing antibody response • Response is specific for the vaccine component antigens • Moderate to significant response following the third immunization • Higher antigen-specific IgG2a antibod ...
... • Chimigen® HIV Vaccine is immunogenic; most of the animals responded • Chimigen® HIV Vaccine is capable of inducing antibody response • Response is specific for the vaccine component antigens • Moderate to significant response following the third immunization • Higher antigen-specific IgG2a antibod ...
Document
... phagocytose, and process them for presentation to effector cells belonging to the acquired immune system (lymphocytes) in the regional lymph nodes. Ultimately, a Th1-type immune response with IFN␥ production and the development of cytotoxic T cells (CTLs) specific for R. equi would have to derive fr ...
... phagocytose, and process them for presentation to effector cells belonging to the acquired immune system (lymphocytes) in the regional lymph nodes. Ultimately, a Th1-type immune response with IFN␥ production and the development of cytotoxic T cells (CTLs) specific for R. equi would have to derive fr ...
Activation of an inflammatory response is context
... Interestingly, despite the growing interest in understanding the costs of deploying or maintaining immune effectors in natural populations, rarely has ontogeny been taken into account in these studies. This is unfortunate, as there is evidence that not only does the immune system develop differently ...
... Interestingly, despite the growing interest in understanding the costs of deploying or maintaining immune effectors in natural populations, rarely has ontogeny been taken into account in these studies. This is unfortunate, as there is evidence that not only does the immune system develop differently ...
Mammary Gland Involution: Events, Regulation and
... transgenic mouse mammary glands show extensive secretory products held within apical membrane outgrowths of alveolar epithelial cells. This suggests an impaired cellular secretory process. Thus, 5-HT and LTF may be working on different aspects of the milk secretion process (gene expression, TJs, exo ...
... transgenic mouse mammary glands show extensive secretory products held within apical membrane outgrowths of alveolar epithelial cells. This suggests an impaired cellular secretory process. Thus, 5-HT and LTF may be working on different aspects of the milk secretion process (gene expression, TJs, exo ...
the Complete 2016 Summit Summary
... discussed its utility predicting and tracking clinical responses in patients with moderate to severe alopecia areata who were treated with Jakafi and Xeljanz in two open label clinical trials. Dr. Zhenpeng Dai, from Columbia University Medical Center, shared results showing that blockade of the Inte ...
... discussed its utility predicting and tracking clinical responses in patients with moderate to severe alopecia areata who were treated with Jakafi and Xeljanz in two open label clinical trials. Dr. Zhenpeng Dai, from Columbia University Medical Center, shared results showing that blockade of the Inte ...
alopecia
... Aside from genetic tendencies, the contributing causes of Alopecia Universalis are not known. It is important that those with it are careful to protect themselves from the sun, bacteria, and other potentially harmful elements, as the scalp, nasal cavity and eyes are not protected. According to the N ...
... Aside from genetic tendencies, the contributing causes of Alopecia Universalis are not known. It is important that those with it are careful to protect themselves from the sun, bacteria, and other potentially harmful elements, as the scalp, nasal cavity and eyes are not protected. According to the N ...
The Role of Complement in Retinal Ganglion Cell Loss in
... the common pathology of a progressive, irreversible vision loss associated with atrophy of retinal ganglion cells. Together, the various forms of glaucoma constitute the second leading cause of vision loss in the developed world. Current therapies for the treatment of glaucoma focus on alleviating t ...
... the common pathology of a progressive, irreversible vision loss associated with atrophy of retinal ganglion cells. Together, the various forms of glaucoma constitute the second leading cause of vision loss in the developed world. Current therapies for the treatment of glaucoma focus on alleviating t ...
The Origins, Specificity, and Potential Biological
... association with chronological age has not been studied to our knowledge (i.e., their presence or absence in young children). However, the presence of HAH autoantibodies can be detected to varying degrees in most healthy adults[6]. Therefore, it seems likely that individuals expressing HAH autoantib ...
... association with chronological age has not been studied to our knowledge (i.e., their presence or absence in young children). However, the presence of HAH autoantibodies can be detected to varying degrees in most healthy adults[6]. Therefore, it seems likely that individuals expressing HAH autoantib ...
Mucosal immune response in common carp (Cyprinus carpio L
... and remember specific pathogens, and to mount stronger and faster response to pathogens. To mount such an immune response, a specific pathogen or antigen needs to be recognized (Aoki et al., 2008). In teleostean fishes, as in mammals, a first antigen encounter will induce some longlived memory cells ...
... and remember specific pathogens, and to mount stronger and faster response to pathogens. To mount such an immune response, a specific pathogen or antigen needs to be recognized (Aoki et al., 2008). In teleostean fishes, as in mammals, a first antigen encounter will induce some longlived memory cells ...
Integrin-associated protein (CD47) and its ligands
... that the two molecules were the same13. Molecular cloning also demonstrated that CD47 was identical to a cancer antigen, OV-3, markedly upregulated on ovarian carcinoma cells compared with normal ovarian cells6. Because the function of this molecule has been studied best in relation to integrin sign ...
... that the two molecules were the same13. Molecular cloning also demonstrated that CD47 was identical to a cancer antigen, OV-3, markedly upregulated on ovarian carcinoma cells compared with normal ovarian cells6. Because the function of this molecule has been studied best in relation to integrin sign ...
Document
... Sponges feed primarily on particles suspended in water pumped through their canal systems. Detritus particles, planktonic organisms, and bacteria are consumed nonselectively in the size range from 50 µm (average diameter of ostia) to 0.1 µm (width of spaces between the microvilli of the choanocyte c ...
... Sponges feed primarily on particles suspended in water pumped through their canal systems. Detritus particles, planktonic organisms, and bacteria are consumed nonselectively in the size range from 50 µm (average diameter of ostia) to 0.1 µm (width of spaces between the microvilli of the choanocyte c ...
Temeyer 2016 tick salivary cholinesterase
... In summary, this is the first report of tick salivary ChE and provides three hypotheses that the salivary ChE plausibly functions 1) to reduce presence of potentially toxic acetylcholine present in the extremely large bloodmeal imbibed during rapid engorgement, 2) to potentially modulate the immune ...
... In summary, this is the first report of tick salivary ChE and provides three hypotheses that the salivary ChE plausibly functions 1) to reduce presence of potentially toxic acetylcholine present in the extremely large bloodmeal imbibed during rapid engorgement, 2) to potentially modulate the immune ...
science - Christian Schools International
... The CSI science program centers on the acknowledgment that the world in which we live belongs to God, who created and upholds it. Through scientific inquiry we can perceive a degree of the amazing complexity and orderliness of God’s world. With this fuller understanding of creation comes a deepened ...
... The CSI science program centers on the acknowledgment that the world in which we live belongs to God, who created and upholds it. Through scientific inquiry we can perceive a degree of the amazing complexity and orderliness of God’s world. With this fuller understanding of creation comes a deepened ...
The Role of Macrophages in Murine Intraocular - Ti
... Local treatment of the primary tumour is very promising and depends on tumour characteristics such as size and localisation (reviewed in (Singh and Singh 2012)). It ranges from enucleation of the globe to eye-saving strategies like local radiation therapy (brachytherapy), thermotherapy or proton bea ...
... Local treatment of the primary tumour is very promising and depends on tumour characteristics such as size and localisation (reviewed in (Singh and Singh 2012)). It ranges from enucleation of the globe to eye-saving strategies like local radiation therapy (brachytherapy), thermotherapy or proton bea ...