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NIH Public Access Author Manuscript The immune system and cardiac repair Abstract
NIH Public Access Author Manuscript The immune system and cardiac repair Abstract

... myocardial infarction is dependent on activation of inflammatory pathways. Infarct healing results in profound changes in ventricular architecture and geometry, also referred to as “ventricular remodeling” [3], [4]. The molecular and cellular changes associated with ventricular remodeling affect bot ...
Exosomes and Exosomal RNA – A Way of Cell-to-Cell
Exosomes and Exosomal RNA – A Way of Cell-to-Cell

... Exosomes are nano-sized extracellular vesicles of endocytic origin participating in cell-to-cell communication, partly by the transfer of exosomal RNA between cells. These extracellular vesicles are released by most cells and found in many body fluids including plasma and urine. Exosomes differ comp ...
Probiotic characteristics of Lactobacillus acidophilus and
Probiotic characteristics of Lactobacillus acidophilus and

... Probiotic characteristics of Lactobacillus acidophilus and Lactobacillus paracasei and their effects on immune response and gene expression in mice ...
Study of PepT1 and SPAK on Intestinal Homeostasis and Intestinal
Study of PepT1 and SPAK on Intestinal Homeostasis and Intestinal

... crypt-villus axis demonstrated that this protein is crucial to the process of di/tripeptide absorption. We recently exhibited that PepT1 plays an important role in multiple biological functions, including the ability to regulate the expression/secretion of specific microRNAs (miRNAs) and the express ...
Murine models of susceptibility to tuberculosis
Murine models of susceptibility to tuberculosis

Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome
Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome

... essential elements of the innate immune system. The AMPs found in human airways include a human cathelicidin (hCAP)18/LL-37, a- and b-defensins, and the proteinase inhibitors secretory leukoprotease inhibitor (SLPI) and elafin [12, 13]. Their release is stimulated by inflammatory cytokines and micro ...
Cenchao Shen - RMIT Research Repository
Cenchao Shen - RMIT Research Repository

... I certify that except where due acknowledgement has been made, the work is that of the author alone; the work has not been submitted previously, in whole or in part, to qualify for any other academic award; the content of the thesis is the result of work which has been carried out since the official ...
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite
(2016) Innate Immunity and Asthma Risk in Amish and Hutterite

... to asthma and allergy,1,2 but the dramatic increase in the prevalence of these conditions in westernized countries in the past halfcentury suggests that the environment also plays a critical role.3 The importance of environmental exposures in the development of asthma is most exquisitely illustrated ...
Pathogenesis of prion diseases
Pathogenesis of prion diseases

... central nervous system and on cells of the immune system. In a given cell type PrPC is necessary, but not sufficient for the replication of prions. PrPSc. PrPSc is an abnormal isoform of the PrPC protein and is found in the tissues of TSE patients. The isoform is partially resistant to digestion by ...
The physiology of blood platelets and changes of their biological
The physiology of blood platelets and changes of their biological

... Boilard et al. 2015, Varon et al. 2015), and are potential mediators of blood coagulation by serving as circulating sources of tissue factor (TF) that is a transmembrane protein involved in thrombin generation. On the surface of MPs some quantity of phospatidylserine – a negatively charged aminophos ...
Immune Responses In Vitro and In Vivo Oligodeoxynucleotide for
Immune Responses In Vitro and In Vivo Oligodeoxynucleotide for

evolutionary causes and consequences of
evolutionary causes and consequences of

... the tissues, as would be appropriate if TNF-α were released in a localized site of infection. Systemic release, however, causes shock—decreased blood volume and multiorgan failure. Mice deficient in TNF-α readily survive a level of sepsis that would kill a normal mouse but succumb to minor bacterial ...
Steht die Psyche unter Druck, leiden die Haare – eine
Steht die Psyche unter Druck, leiden die Haare – eine

... epithelium of organ-cultured anagen hair bulbs, likely via interferon regulatory factor-1, along with up-regulation of the MHC class I pathway molecules beta(2)microglobulin and transporter associated with antigen processing (TAP-2). In the first report to identify natural immunomodulators capable o ...
acute viral myocarditis: current concepts in diagnosis and treatment reviews
acute viral myocarditis: current concepts in diagnosis and treatment reviews

... the endothelium of myocardial vessels of patients with acute myocarditis was ten thousand times higher than the load in viral myocarditis plays a major role in the development of patients with chronic myocardial inflammation or in controls inflammatory cardiomyopathy [1]. with no inflammation at all ...
Chronic inflammation
Chronic inflammation

... Activated macrophages secrete bio-oxidant that initiate lipid peroxidation in the membrane of other cells in the infiltrated area. However, simply increasing chemotaxin in some tissue site has not meant to influx of new inflammatory effector cells from the blood. It is necessary that along with the ...
Innate cellular responses to rotavirus infection
Innate cellular responses to rotavirus infection

Ketamine and Peripheral Inflammation
Ketamine and Peripheral Inflammation

... inflammatory stimulus. Second, its regulatory action is more pronounced when this drug is administered before the inflammatory challenge [36]. This is of particular interest knowing that ketamine is mostly given at the induction of anesthesia before surgery. Early experimental studies have mainly fo ...
Thesis_Panitz
Thesis_Panitz

Table 1: Membrane damaging toxins
Table 1: Membrane damaging toxins

... membrane [Simpson et al, 1971; Kazoki et al, inhibits neurotransmitter release (iv). [Schematic 1998]. These lipid molecules have a role in representation adopted from Breidenbach et al, 2005] signal transduction and seem to be important in the development of neurons. The only BoNT that does not bin ...
Mechanisms underlying stress-induced hyperglycemia in critically ill
Mechanisms underlying stress-induced hyperglycemia in critically ill

... enhanced blood glucose levels occur during stressful situations, such as acute illnesses. These disturbances associate with poor prognostic events. Intensive insulin therapy and maintaining normoglycemia reduce the morbidity and mortality rate in critically ill patients. We aim to give an overview o ...
Melatonin, sleep disturbance and cancer risk
Melatonin, sleep disturbance and cancer risk

GM-CSF in the Lung Protects against Lethal
GM-CSF in the Lung Protects against Lethal

... pandemic. The tremendous human burden of influenza mandates improved methods to prevent and treat this infection. Control and clearance of influenza infection are believed to hinge on adaptive immunity, mediated by B and T cells. B cells produce antibodies to influenza hemagglutinin and neuraminidas ...
Chromatin as a target antigen in human and murine lupus nephritis
Chromatin as a target antigen in human and murine lupus nephritis

... alterations during apoptosis and is normally not exposed for the immune system. In the case of increased apoptosis or deficient clearance, however, these components may be exposed as secondary necrotic chromatin with the potential to induce an antigen-selective immune response [64-66]. For example, p ...
The Role of Donor‐Specific HLA Alloantibodies in Liver
The Role of Donor‐Specific HLA Alloantibodies in Liver

... otherwise unexplained liver allograft dysfunction, falling platelet and complement levels and increased levels of circulating immune complexes in patients with preformed persistent DSA in whom liver biopsy shows microvascular injury in addition to other characteristics commonly associated with allog ...
The human spleen after trauma Leemans, Rob
The human spleen after trauma Leemans, Rob

... B-cells (centroblasts and centrocytes), a few T-cells and follicular dendritic reticulum cells. In the lymphoid follicles a special type of dendritic cells (follicular dendritic cells) is found, which are able to bind immune complexes. They can maintain immune complexes on their cell surface for a l ...
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Adoptive cell transfer

Adoptive cell transfer (ACT) is the transfer of cells into a patient; as a form of cancer immunotherapy. The cells may have originated from the patient him- or herself and then been altered before being transferred back, or, they may have come from another individual. The cells are most commonly derived from the immune system, with the goal of transferring improved immune functionality and characteristics along with the cells back to the patient. Transferring autologous cells, or cells from the patient, minimizes graft-versus-host disease (GVHD) or what is more casually described as tissue or organ rejection.
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