Pathophysiology and differential diagnosis of anaemia
... These result from the presence of antibodies targeting one or more of the numerous RBC membrane antigens. This condition is frequently associated with other autoimmune or lymphoproliferative disorders, and can also be induced by drugs (hapten-related reactions) or infections (bacterial or viral). De ...
... These result from the presence of antibodies targeting one or more of the numerous RBC membrane antigens. This condition is frequently associated with other autoimmune or lymphoproliferative disorders, and can also be induced by drugs (hapten-related reactions) or infections (bacterial or viral). De ...
The source of fatty acids incorporated into proliferating lymphoid
... guinea pigs ate standard chow for the last 5 d, during which swelling of one popliteal lymph node was stimulated by repeated local injection of lipopolysaccharide. The fatty acid compositions of phospholipids in both popliteal and in several mesenteric lymph nodes, and of triacylglycerols in eleven ...
... guinea pigs ate standard chow for the last 5 d, during which swelling of one popliteal lymph node was stimulated by repeated local injection of lipopolysaccharide. The fatty acid compositions of phospholipids in both popliteal and in several mesenteric lymph nodes, and of triacylglycerols in eleven ...
Relation Between HLA-G Gene Null Allele (HLA
... HLA-G, like other class I genes, has 8 exons: exon 1 encodes a signal peptide, exons 2, 3, and 4, encode extracellular globular domains (α1, α2 and α3 domains, respectively), exon 5 encodes membrane-anchored domain and exons 6 and 7 encode one intracytoplasmic domain (16). α1 and α2 domains create t ...
... HLA-G, like other class I genes, has 8 exons: exon 1 encodes a signal peptide, exons 2, 3, and 4, encode extracellular globular domains (α1, α2 and α3 domains, respectively), exon 5 encodes membrane-anchored domain and exons 6 and 7 encode one intracytoplasmic domain (16). α1 and α2 domains create t ...
enzyme-linked immunosorbent assay (ELISA) of this antigen became avail-
... A: The vast majority of detected cancers by PSA screening (>80%) appear to be clinically significant, pose a threat to patient life and require definitive treatment. 7) Q: How much earlier can a PSA screening test detect a prostate cancer in comparison to clinical diagnosis? A: Three to five years. ...
... A: The vast majority of detected cancers by PSA screening (>80%) appear to be clinically significant, pose a threat to patient life and require definitive treatment. 7) Q: How much earlier can a PSA screening test detect a prostate cancer in comparison to clinical diagnosis? A: Three to five years. ...
Alopecia areata update
... In children, the most important entities to rule out diffuse and total alopecia, which was first described are tinea capitis and trichotillomania. Tinea capitis by Sato-Kawamura et al14 and was reported more can be differentiated by the presence of inflammation recently by Lew et al15 in a larger se ...
... In children, the most important entities to rule out diffuse and total alopecia, which was first described are tinea capitis and trichotillomania. Tinea capitis by Sato-Kawamura et al14 and was reported more can be differentiated by the presence of inflammation recently by Lew et al15 in a larger se ...
An Introduction to Lipid Rafts
... Isolation of lipid rafts is accomplished, using non-ionic detergents, such as Triton X100 and Brij (12). Since the upper limit of the solubility of Brij at 4℃ is 0.5%, while rafts are usually prepared using Triton X-100 of 1% concentration, the two detergent concentrations are applied here. When ei ...
... Isolation of lipid rafts is accomplished, using non-ionic detergents, such as Triton X100 and Brij (12). Since the upper limit of the solubility of Brij at 4℃ is 0.5%, while rafts are usually prepared using Triton X-100 of 1% concentration, the two detergent concentrations are applied here. When ei ...
PDF
... and digest potential pathogens as well as cell debris. Internalized pathogens are contained in phagosomes, where antimicrobial peptides from cellular granules and reactive oxygen species (ROS) produced by NADPH oxidase work together to create a toxic environment for most pathogens (Underhill and Ozi ...
... and digest potential pathogens as well as cell debris. Internalized pathogens are contained in phagosomes, where antimicrobial peptides from cellular granules and reactive oxygen species (ROS) produced by NADPH oxidase work together to create a toxic environment for most pathogens (Underhill and Ozi ...
Embrionary way to create a fatty liver in portal hypertension
... transmigration of free cells, such as dendritic cells and lymphocytes, have been shown[34]. In addition, the edematous space of Disse may also serve as a stem cell niche for substances derived from the neuro-endocrine response to portal hypertensive stress, for mediators of the acute phase response ...
... transmigration of free cells, such as dendritic cells and lymphocytes, have been shown[34]. In addition, the edematous space of Disse may also serve as a stem cell niche for substances derived from the neuro-endocrine response to portal hypertensive stress, for mediators of the acute phase response ...
Biological properties of extracellular vesicles and their physiological
... platelet-derived particles in normal plasma, originally reported in 1946 by Chargaff and West (2) and referred to as ‘‘platelet dust’’ by Wolf in 1967 (3). Early observations also included matrix vesicles identified during bone calcification by Anderson in 1969 (4). In the 19701980s, separate indep ...
... platelet-derived particles in normal plasma, originally reported in 1946 by Chargaff and West (2) and referred to as ‘‘platelet dust’’ by Wolf in 1967 (3). Early observations also included matrix vesicles identified during bone calcification by Anderson in 1969 (4). In the 19701980s, separate indep ...
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent
... 2012). Type I IFNs have important roles in the induction of adaptive immunity, they promote the generation of cytotoxic T cell responses as well as a Th1 biased CD4+ T cell phenotype (Tough, 2012). Furthermore, type I IFNs promote the activation and functional maturation of DCs, increasing their mig ...
... 2012). Type I IFNs have important roles in the induction of adaptive immunity, they promote the generation of cytotoxic T cell responses as well as a Th1 biased CD4+ T cell phenotype (Tough, 2012). Furthermore, type I IFNs promote the activation and functional maturation of DCs, increasing their mig ...
TUMOR NECROSIS FACTOR ALPHA (TNF-a)
... adaptor proteins TRADD, RIP1, and TRAF2, which can activate the NF-kB pathway via an I-kB kinase complex composed of I-kB kinase-a, I-kB kinase-b, and I-kB kinase-g (NEMO). Alternatively, TNFR1 signaling through TRAF2 can activate the c-Jun N-terminal kinase (JNK) pathway through the MAPK kinase, MK ...
... adaptor proteins TRADD, RIP1, and TRAF2, which can activate the NF-kB pathway via an I-kB kinase complex composed of I-kB kinase-a, I-kB kinase-b, and I-kB kinase-g (NEMO). Alternatively, TNFR1 signaling through TRAF2 can activate the c-Jun N-terminal kinase (JNK) pathway through the MAPK kinase, MK ...
NIH Public Access
... per day, which can increase to 1012 per day during bacterial infection. Thus, not surprisingly, 55% to 60% of the bone marrow is dedicated to their production (2). Neutrophils are terminally differentiated and relatively short lived. Traditional estimates based on ex vivo survival in culture or on h ...
... per day, which can increase to 1012 per day during bacterial infection. Thus, not surprisingly, 55% to 60% of the bone marrow is dedicated to their production (2). Neutrophils are terminally differentiated and relatively short lived. Traditional estimates based on ex vivo survival in culture or on h ...
The Immune System
... Innate Immune System Adaptive Immune System Pattern Recognition in the Immune System Basic Immune Recognition and Activation Clonal Selection and Affinity Maturation ...
... Innate Immune System Adaptive Immune System Pattern Recognition in the Immune System Basic Immune Recognition and Activation Clonal Selection and Affinity Maturation ...
Monoclonal Antibodies for Therapeutic Use: Specific Characteristics
... The use of animal models during the development of MoAb is difficult due to the between-species differences of the “partners” of the MoAb, i.e. target antigen and immune effectors (including FcγR receptors).[19] MoAb do not usually recognise target antigens in the mouse. These models therefore requi ...
... The use of animal models during the development of MoAb is difficult due to the between-species differences of the “partners” of the MoAb, i.e. target antigen and immune effectors (including FcγR receptors).[19] MoAb do not usually recognise target antigens in the mouse. These models therefore requi ...
Is lipid signaling through cannabinoid 2 receptors part of a protective
... that through evolution analogous biological protective systems have been evolved against non-protein attacks. There is emerging evidence that lipid endocannabinoid signaling through cannabinoid 2 (CB2) receptors may represent an example/part of such a protective system/armamentarium. Inflammation/ti ...
... that through evolution analogous biological protective systems have been evolved against non-protein attacks. There is emerging evidence that lipid endocannabinoid signaling through cannabinoid 2 (CB2) receptors may represent an example/part of such a protective system/armamentarium. Inflammation/ti ...
Update on allergy immunotherapy - Journal of Allergy and Clinical
... T cells (TH2-like cells) exist at a high frequency.8,9 Hence a change in the dominant subset toward IL-4 might lead to the development of allergy, whereas IL-10 dominance leads to recovery. Peripheral tolerance to allergens involves multiple suppressive factors, such as IL-10, TGF-b, cytotoxic T lym ...
... T cells (TH2-like cells) exist at a high frequency.8,9 Hence a change in the dominant subset toward IL-4 might lead to the development of allergy, whereas IL-10 dominance leads to recovery. Peripheral tolerance to allergens involves multiple suppressive factors, such as IL-10, TGF-b, cytotoxic T lym ...
Microbial Exposure and Asthma - Digital Commons @ Liberty
... deoxyribonucleic acid (DNA) which would otherwise be undetectable with cultures. In the GABRIELA study, dust samples were collected using electrostatic cloths mounted on plastic sample holders. The electrostatic dust collectors were placed in the children’s rooms, where they remained for 14 days. Th ...
... deoxyribonucleic acid (DNA) which would otherwise be undetectable with cultures. In the GABRIELA study, dust samples were collected using electrostatic cloths mounted on plastic sample holders. The electrostatic dust collectors were placed in the children’s rooms, where they remained for 14 days. Th ...
STUDIES ON THE IMMOBILIZATION ANTIGENS OF PARAMECIUM
... was incubated two to three hours at 37"C, and then to each was added two parts of antiserum diluted with buffered saline. The antiserum was 25 times as strong as the greatest dilution giving complete immobilization in one half hour. After five minutes the mixtures were diluted by adding 36 parts of ...
... was incubated two to three hours at 37"C, and then to each was added two parts of antiserum diluted with buffered saline. The antiserum was 25 times as strong as the greatest dilution giving complete immobilization in one half hour. After five minutes the mixtures were diluted by adding 36 parts of ...
TOWARDS A DETAILED UNDERSTANDING OF THE RED BLOOD
... References ................................................................................... 46 ...
... References ................................................................................... 46 ...
Adverse Transfusion Reactions
... primary function transportation of oxygen to tissues - White Blood Cells (WBC) or leukocytes primary function cellular immunity - Platelets (PLT) primary function initiating coagulation Figure 1. Composition of blood ...
... primary function transportation of oxygen to tissues - White Blood Cells (WBC) or leukocytes primary function cellular immunity - Platelets (PLT) primary function initiating coagulation Figure 1. Composition of blood ...