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Mycoplasmas
Mycoplasmas

Current Strategies in HIV-1 Vaccine Development Using
Current Strategies in HIV-1 Vaccine Development Using

... Genetic diversity is continuously generated in a single infected individual Vaccine needs to elicit both mucosal and systemic immunity High levels of viral replication persist in face of seemingly robust anti-viral antibody and cell-mediated immune responses ...
Immunology for Anaesthetists Part 1 - Basic Immunology
Immunology for Anaesthetists Part 1 - Basic Immunology

... Activation of naïve T-cells occurs in a process called ‘antigen presentation’. Dendritic cells and macrophages involved in the innate response migrate to lymphoid tissue where they present antigen in association with MHC, this is why they are called antigen presenting cells (APCs). CD8+ T-cells are ...
Media Release
Media Release

... development and release of proinflammatory T cells from the intestinal wall to other areas in the body, including the brain. This caused more severe disease in the mice. On the contrary, shortchain fatty acids, such as propionate, promoted the development and propagation of regulatory T cells that k ...
Immune System Study Sheet
Immune System Study Sheet

Immune responses in viral infections
Immune responses in viral infections

... 1. Antigenic variation (Influenza, HIV, rhinovirus). Viruses can alter their antigens, influenza viruses show changes in antigenicity(antigenic shifts and drifts). Because of antigenic variation, a virus may become resistant to immunity generated in the population by previous infection. 2. Inhibitio ...
Microbiology: Major Histocompatability Complex (MHC) pg. 1 Marc
Microbiology: Major Histocompatability Complex (MHC) pg. 1 Marc

... Slide 13: Shown is a Th cell helping a B cell. The B cell’s MHC Class II complex binds with the Th cell’s TCR. The Th cell then secretes IL-4 (a cytokine which promotes isotype switching) directly into the B cell. Slide 14, 15: Both MHC classes are membrane-bound glycoproteins with 4 domains: 2 memb ...
Qi Mail - Needles and Tea
Qi Mail - Needles and Tea

... diseases which encompass a broad category of over 100 diseases in which the person's immune system attacks his or her own tissue. ...
Antibodies - STEMCELL Technologies
Antibodies - STEMCELL Technologies

... The RMEPCR1560 antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines. It is also found in a soluble form in ...
Immune System:
Immune System:

... 1. Mechanical mechanisms: such as skin and mucous membranes form barriers that prevent the entry of chemicals and microorganisms into the tissues of the body. For example, substances are washed from the eyes by the tears, from the mouth by saliva, and from the urinary tract by urine. 2. Chemical med ...


... replication to a critical threshold bacillary load these same virulent strains can induce an alternative death mode with initial features of apoptosis but rapid progression to necrosis. This cell death mechanism is independent of TNF, caspases or Bax and Bak and it releases viable bacilli. An emergi ...
(b) activate the adaptive immune response
(b) activate the adaptive immune response

... of histologically apparent cytologic changes, cellular infiltration, and mediator release that occurs in the affected blood vessels and adjacent tissues in response to an injury or abnormal stimulation caused by a physical, chemical, or biologic agent, including the local reactions and resulting mor ...
3 Innate immunity I
3 Innate immunity I

... •These cells are phagocytes (eliminate the pathogens) •Activate the innate immune response (by secreted proteins, called cytokines) •Activate the adaptive immune system. Macrophages serve as APCs that display antigens to and activate T lymphocytes ...
8.2 Structure of DNA
8.2 Structure of DNA

... feeding, child birth, etc.) • The risk of exposure to HIV through sexual contact can be reduced by using latex protection (condoms) • A minority of people are immune to HIV infection (they do not have the CD4+ T cell receptor that HIV needs to infect the cell) ...
Lymphatic System and Immunity
Lymphatic System and Immunity

... to a foreign substance that may cause tissue damage. ...
穨 bio
穨 bio

CELLS, ORGANS, AND MOLECULES: ANATOMY
CELLS, ORGANS, AND MOLECULES: ANATOMY

... has just a single specificity, different from nearly all the others. T cell receptors are composed of alpha and beta chains. B cell receptors are samples of the antibodies that the cell will eventually secrete. The part of an antigen that fits into the receptor is the antigenic determinant or epitop ...
Immunity - Fort Bend ISD / Homepage
Immunity - Fort Bend ISD / Homepage

... Triggered by tissue damage Blood supply to area increases Chemical signals are released ...
Chapter 18 Textbook Review pg. 621-622 (#1
Chapter 18 Textbook Review pg. 621-622 (#1

... the body’s immune response. The body loses its ability to produces antibodies that fight specific diseases. (20) Compare and contrast active immunity and passive immunity. Then, describe one way in which a person can acquire each type of immunity. Active immunity is a process in which antibodies are ...
AIDS - GEOCITIES.ws
AIDS - GEOCITIES.ws

... cell count of < 200 (normally 1000 cells/ml blood) + serologic evidence of HIV. Read pp 198 for opportunistic infections and when they occur. HIV – VIRAL LOAD VS CD4 COUNT Using PCR you can measure the plasma HIV RNA. The more plasma HIV RNA = more viral load = poorer prognosis. So you can use CD4 ...
Adaptive Immunity: Specific Defenses of the Host
Adaptive Immunity: Specific Defenses of the Host

...  Antigen (Ag): A substance that causes the body to produce specific antibodies or sensitized T cells.  Antibody (Ab): Proteins made in response to an Ag; can combine with that Ag.  Serology: The study of reactions between antibodies and antigens.  Antiserum: A generic term for serum because it c ...
PowerPoint
PowerPoint

... Innate immunity: An individual’s genetically predetermined resistance to certain diseases. Adaptive immunity: Ability of the body to react to specific microbial infection. Adaptive immunity  is antigen specific, has memory  is made up of two branches Humoral Immunity (B cell mediated) Cellular I ...
What`s so great about a little Cell?
What`s so great about a little Cell?

... The cell is the most basic unit of life, performing all of the functions necessary for life. In the eukaryotic vertebrate cell these functions are performed by various organelles within the cell. The cell membrane plays a role in the dynamic process of molecular movement in and out of the cell. At ...
new vaccines for allergic rhinitis
new vaccines for allergic rhinitis

... immunotherapy (SIT) is used in selected human patients with allergic disease and offers the advantage of being antigen-specific and potentially curative. SIT involves the subcutaneous injection of incremental doses of allergen extract to induce a state of clinical tolerance on reexposure to the alle ...
Anatomy - Immune system - UK College of Agriculture
Anatomy - Immune system - UK College of Agriculture

< 1 ... 381 382 383 384 385 386 387 388 389 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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