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SAFETY IMPLICATIONS FOR BIOTECH PRODUCTS
SAFETY IMPLICATIONS FOR BIOTECH PRODUCTS

Immunity - porterhealthscience
Immunity - porterhealthscience

AP Virus Day 1
AP Virus Day 1

... – When exposed to smallpox, the boy resisted the disease. – Because of their similarities, vaccination with the cowpox virus sensitizes the immune system to react vigorously if exposed to actual smallpox virus. • Effective vaccines against many other viruses exist. ...
regulatory T cells, Treg cells
regulatory T cells, Treg cells

... T Cells Bearing the Pre-TCR • Once the Pre-TCR is produced, an activation signal can be transduced across the membrane to initiate several actions. – Indicates that the cell has made a TCR  chain and signals further proliferation and maturation. – Suppresses further rearrangement of TCR , resulti ...
HO-notecards
HO-notecards

... Type B=most prevelant, Type A=20% of healthy Af-Ams have this. Af. Mutant A- unstable and loses activity; Mediteranian always low base activity X-linked Clincal features: triggered by drugs, infections, maximal 7-10d of drug exposure Tx: avoid oxidant agents, folate repletion ...
ch 12 test-reproduction - Sarah Mahajan Study Guides
ch 12 test-reproduction - Sarah Mahajan Study Guides

... -provided by two types of lymphocytes: -B cells: trigger antibodies that are specific to antigens -T cells: look for cells that are infected with viruses but haven’t exploded yet -inject poison into the cell, killing the cell which prevents the virus from reproducing -develop in bone marrow and matu ...
The Immune System
The Immune System

... CD8 cells are T cells that have a protein called CD8 on their surface. When CD8 cells recognize a specific infection, such as HIV, they can develop into what are often referred to as killer T cells or CTLs (cytotoxic T lymphocytes). These killer T cells seek out and kill other cells that are already ...
Immune Network: An Example of Complex Adaptive Systems
Immune Network: An Example of Complex Adaptive Systems

... within the framework of this theory. For example, what makes the memory cells retain their memory? One possibility is that some kind of stimulation of the immune system persists even after the antigen population falls below the tolerance level; in that case memory cells are nothing but cells which a ...
CS12 Herpes Simplex Virus_Presentation
CS12 Herpes Simplex Virus_Presentation

... • Although HSV-1 and HSV-2 have many antigens in common, the glycoprotein G (gG) antigen is unique to each type; thus, gG1 is found only on HSV-1, and gG2 is found only on HSV-2. • ELISA based test can be used to detect type-specific IgG antibodies (sensitivity around 90%). • Western Blot • PCR ...
PDF of PowerPoint
PDF of PowerPoint

Previews Synaptic Asymmetry to Go Leading Edge Michael L. Dustin
Previews Synaptic Asymmetry to Go Leading Edge Michael L. Dustin

... subset of naive CD4+ T cells 6–12 hr after the initiation of T cell receptor signaling. They establish that expression of Crtam is required for early (12–48 hr) production of interferon-γ and IL-22 and show that Crtam-deficient T cells display hyperproliferation and decreased transcription of genes ...
PowerPoint Presentation - Cell-Mediated Immunity
PowerPoint Presentation - Cell-Mediated Immunity

... • Positive selection: T cells which can react to self MHC (major histocompatability complex) carrying peptides are allowed to live. Those that cannot undergo apoptosis (suicide). • Negative selection: T cells that react strongly to self-antigens on MHC are eliminated. • Only those T cells that can r ...
The Medical Importance of the Immune System
The Medical Importance of the Immune System

HIV-1 Lifecycle (Assembly and Maturation)
HIV-1 Lifecycle (Assembly and Maturation)

... • At CD4 cell counts over 500 cells/uL many complications overlap with conditions found in uninfected populations (bacterial pneumonia, tuberculosis, minor skin conditions), but they may be more frequent. ...
Autoimmune dz`s
Autoimmune dz`s

... – Vaccines • create a “memory” (l’cyte) response, incl. suppressor T cells. ...
I. Host responses during infection
I. Host responses during infection

... Histamine acts on capillary walls Causes dilation ...
Hemolytic anemias
Hemolytic anemias

... increased, the body initially compensates by producing more RBCs; however, breakdown of RBCs can exceed the rate that the body can make RBCs, and so anemia can develop. ...
New Oral Treatments for Multiple Sclerosis
New Oral Treatments for Multiple Sclerosis

... lymphocytes to egress from lymph nodes. This reduces overall lymphocyte count meaning less are available to migrate to the CNS. • Teriflunomide (Aubagio) works by inhibiting de novo pyrimidine synthesis at the DHODH step, thus blocking the ability of lymphocytes to proliferate • Tecfidera reduces in ...
89 Blood typ cont`d
89 Blood typ cont`d

... A1 Negative (A1 -ve) A1 Positive (A1 +ve) A1B Negative (A1B -ve) A1B Positive (A1B +ve) A2 Negative (A2 -ve) A2 Positive (A2 +ve) A2B Negative (A2B -ve) A2B Positive (A2B +ve) B Negative (B -ve) B Positive (B +ve) B1 Positive (B1 +ve) ...
Physical and Chemical Barriers
Physical and Chemical Barriers

... The lymphatic system is part of your immune system. It includes your tonsils, lymph nodes, and a network of vessels, similar to blood vessels, that transport lymph, or tissue fluid. ...
Malaria Drugs and Vaccine
Malaria Drugs and Vaccine

... Artemisinin is not toxic until it is cleaved inside the parasite by exposure to heme-iron A resulting free radical intermediate may kill the parasite by poisoning one or more essential malarial protein(s). ...
Lymphocyte activity and protein synthesis
Lymphocyte activity and protein synthesis

Malaria Drugs and Vaccine
Malaria Drugs and Vaccine

... Artemisinin is not toxic until it is cleaved inside the parasite by exposure to heme-iron A resulting free radical intermediate may kill the parasite by poisoning one or more essential malarial protein(s). ...
preventing-disease-2
preventing-disease-2

... PHAGOSOME. Small lysosomes fuse with the phagocyte forming a phagolysosome, Lysozyme and other hydrolytic enzymes and acid are poured in from lysozome and the bacteria are digested. The soluble products of digestion are absorbed into the surrounding cytoplasm This also results in some of the antigen ...
Antigen Processing and Presentation
Antigen Processing and Presentation

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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