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Sequencing genomes
Sequencing genomes

... A new species of frog has been introduced into an area where it has too few natural predators. In an attempt to restore the ecological balance, a team of scientists is considering introducing a species of bird which feeds on this frog. Experimental data suggests that the population of frogs and bird ...
Document
Document

... • ss – …SmZF1 binds both ds and ss DNA oligonucleotides,… (TN) – Coexpression of Ss and Tgo in Drosophila SL2 cells… (TP) – The origin of germline-limited chromosomes (Ks) as descendants of somatic chromosomes (Ss) and their… (FP) ...
Ultraconserved Elements in the Human Genome
Ultraconserved Elements in the Human Genome

... EIF2C1, BCL11A, EVI1, ZFR, CLK4, HNRPH1, and DDX5, as well as GRIA3. In none of the other cases could we find evidence that any element that was intronic in human was coding in another species, although in some cases there was EST evidence for a retained intron that presumably has a function other t ...
Document
Document

... Introduction to Functional Analysis J.L. Mosquera and Alex Sanchez ...
Promoter identification
Promoter identification

... completely conserved ⟹ similar elements will be found purely by chance all over the genome. ...
Genome Rearrangements, Synteny, and Comparative Mapping
Genome Rearrangements, Synteny, and Comparative Mapping

... • No net gain or loss of genetic material: normal phenotype. • Increased risk for an abnormal child or spontaneous pregnancy loss ...
Highly efficient genome engineering in flowering plants
Highly efficient genome engineering in flowering plants

... sequence, is a rapidly developing technique. So far, the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein 9) system is one of the most popular methods for genetic manipulation arising from its simplicity, versatility and efficiency. Nonetheless, the ...
The Gene Concept - bioinf.uni
The Gene Concept - bioinf.uni

... results in a sequence that does not exist in the genome as such (hint: introns) conceptual translation of the “gene” does not necessarely result in an existing functional product (example: A+B+C does not exist) ...
Nomenclature of Transposable Elements in Prokaryotes
Nomenclature of Transposable Elements in Prokaryotes

... each IS2 in a different location a specific as well as a generic name. Such a designation would provide no additional information not already given by the mutation number (see below) that identifies the insertion event. This situation may change in the future for two reasons: (1) IS2 elements may be ...
Chapter 21 The Genetic Control of Animal Development
Chapter 21 The Genetic Control of Animal Development

...  Segment-polarity genes define the anterior and posterior compartments of individual segments.  Mutations in segment-polarity genes cause part of each segment to be replaced by a mirror-image copy of an adjoining half-segment.  Segment-polarity genes refine the segmental pattern established by th ...
CRISPR-Cas Gene Editing to Cure Serious Diseases: Treat the
CRISPR-Cas Gene Editing to Cure Serious Diseases: Treat the

... patient and are not passed on to or altering the gene pool for future generations. Ethical support for providing gene editing therapies in a somatic cell is much like any other therapy directed at and for the patient, grounded in the principles of autonomy (the patient’s right to decide), beneficenc ...
Perspectives Provided by Leopard and Other Cat
Perspectives Provided by Leopard and Other Cat

... herbivore genomes, shared evolutionary adaptations in genes associated with nutrient metabolism, muscle strength, agility, and other traits responsible for hunting and meat digestion. We found genetic evidence that genomes represent what animals eat through modifying genes. Highly conserved genetica ...
158-15(10-7-00) Human, Mouse, Rat . . . What`s Next?: Scientists
158-15(10-7-00) Human, Mouse, Rat . . . What`s Next?: Scientists

... King and Wilson’s initial estimate has held up well as geneticists have used more recently developed methods to directly compare the DNA sequences of a few chimp and human genes. These limited studies have consistently shown that the two genomes differ by 1 to 1.5 percent. What does that number mean ...
Spr01Exam II Answer Key
Spr01Exam II Answer Key

... the game ended. Health officials quickly zeroed in on the arena’s hot dogs as the culprit. Scientists were easily able to isolate a bacteria from the hot dogs that appears almost identical to the common nonpathogenic strain of E.coli that is normally found in our intestines. When culturing the bacte ...
AP Bio Ch.18 “Genetics of Viruses and Bacteria” The Genetics of Viruses
AP Bio Ch.18 “Genetics of Viruses and Bacteria” The Genetics of Viruses

... expression of different genes by cells with the same genome. 6. Describe at what level gene expression is generally controlled. Fig. 19.3 Other examples are places where expression can be turned on or off, accelerated, or slowed down. Activity: “Control of Transcription”, “PostTranscriptional Contro ...
Overview - University of Missouri
Overview - University of Missouri

... data of offspring from two parents which differ in their appearance. Similar fingerprint data for two gene indicates they are physically close together on a chromosome. ...
Analysis of flower pigmentation mutants generated by random
Analysis of flower pigmentation mutants generated by random

... dTph1 element had inserted 30 bp upstream the translation start, without inactivating the gene. This ‘cryptic’ element was responsible for the creation of a stable recessive (untagged) an3 allele, where a large rearrangement inactivated the gene. These findings indicate that mutants for novel loci a ...
No Slide Title - University of Vermont
No Slide Title - University of Vermont

... – Clustering: organization of genes that are similar to each other – Statistical analysis: how significant are the results? ...
Deletion loops in polytene chromosomes
Deletion loops in polytene chromosomes

... Most SINES and LINES in human genome are defective TEs Nonautonomous elements – need activity of nondeleted copies of same TE for movement Autonomous elements – move by themselves ...
polymorphism
polymorphism

... Severe human diseases, such as mental retardation, immunodeficiencies, and cancer, are caused by changes in the coding regions of certain genes. Neurofibromatosis, a tumor disease, is an example of a human disease caused by the insertion of an Alu transposon into the coding region of a gene, the NF ...
Recombinant DNA
Recombinant DNA

... 26.3 Gene Therapy • Gene therapy is the insertion of genetic material into human cells for the treatment of genetic disorders, cardiovascular disease and cancer. • Various methods of gene transfer have been used. – Viruses, genetically modified to be safe, can be used to introduce a normal gene int ...
011 Chapter 11 Microbial Genetics: Gene Structure Replication amp
011 Chapter 11 Microbial Genetics: Gene Structure Replication amp

... B. plants C. mammals D. most insects 17. Key sequences exist within promoters, which vary somewhat among various promoters but are sufficiently constant that they can be represented by a sequence of bases most often found at each position. These representations are called __________ sequences. A. co ...
Bioinformatics Overview, NCBI & GenBank
Bioinformatics Overview, NCBI & GenBank

... • All sequences must be > 50 bp in length and be sequenced by, or on behalf of, the group submitting the sequence. • GenBank will not accept sequences constructed in silico • GenBank will not accept noncontiguous sequences containing ...
Exporter la page en pdf
Exporter la page en pdf

... The SANT domain is a nucleosome recognition module found in transcriptional regulatory proteins, including chromatin-modifying enzymes. It shows high functional degeneracy between species, varying in sequence and copy number. Here, we investigate functions in vivo associated with two SANT motifs, SA ...
PAG2006workshop
PAG2006workshop

... (If some website features don’t work correctly, try using a different browser) ...
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Transposable element



A transposable element (TE or transposon) is a DNA sequence that can change its position within the genome, sometimes creating or reversing mutations and altering the cell's genome size. Transposition often results in duplication of the TE. Barbara McClintock's discovery of these jumping genes earned her a Nobel prize in 1983.TEs make up a large fraction of the C-value of eukaryotic cells. There are at least two classes of TEs: class I TEs generally function via reverse transcription, while class II TEs encode the protein transposase, which they require for insertion and excision, and some of these TEs also encode other proteins. It has been shown that TEs are important in genome function and evolution. In Oxytricha, which has a unique genetic system, they play a critical role in development. They are also very useful to researchers as a means to alter DNA inside a living organism.
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