Sequences 5` to Translation Start Regulate
... Studies that define the c/s-acting elements in 5' promoter regions generally use deletion analysis of the pertinent sequences (Morelli et al., 1985; Nagy et al., 1985; Timko et al., 1985); however, this type of analysis can give misleading results if duplicated sequence elements are involved. We cho ...
... Studies that define the c/s-acting elements in 5' promoter regions generally use deletion analysis of the pertinent sequences (Morelli et al., 1985; Nagy et al., 1985; Timko et al., 1985); however, this type of analysis can give misleading results if duplicated sequence elements are involved. We cho ...
High mutation rates in human and ape pseudoautosomal genes
... ectopic recombination with homologous sequences in the subtelomeric regions of the other chromosomes (Mefford and Trask, 2002). Human X and Y chromosomes pair and recombine in two small pseudoautosomal regions (PARs) at both ends of the sex chromosomes (Cooke et al., 1985; Freije et al., 1992). The ...
... ectopic recombination with homologous sequences in the subtelomeric regions of the other chromosomes (Mefford and Trask, 2002). Human X and Y chromosomes pair and recombine in two small pseudoautosomal regions (PARs) at both ends of the sex chromosomes (Cooke et al., 1985; Freije et al., 1992). The ...
Genomic imprinting and the units of adaptation
... Again, the optimization program (7) permits formal definitions of phenotypic optimality and suboptimality: an optimal phenotype p* is one that maximizes inclusive fitness within the constraints imposed by the strategy set, that is, p*AP: H(p*;P)XH(p;P)8pAP; and a suboptimal phenotype p1 is one that ...
... Again, the optimization program (7) permits formal definitions of phenotypic optimality and suboptimality: an optimal phenotype p* is one that maximizes inclusive fitness within the constraints imposed by the strategy set, that is, p*AP: H(p*;P)XH(p;P)8pAP; and a suboptimal phenotype p1 is one that ...
Isolation of a gene encoding a novel chloroplast protein by T
... sequence. The fusion of the truncated gene to the end of the T-DNA altered the reading frame such that four codons for the C-terminal amino acids of the wild-type protein were replaced by 11 new codons (Figure 4). A DNA sequence of 16 bp located at the T-DNA -plant DNA junction showed homology to ne ...
... sequence. The fusion of the truncated gene to the end of the T-DNA altered the reading frame such that four codons for the C-terminal amino acids of the wild-type protein were replaced by 11 new codons (Figure 4). A DNA sequence of 16 bp located at the T-DNA -plant DNA junction showed homology to ne ...
Reconstruction of a Functional Human Gene Network, with an
... of disorders for which numerous loci have been reported but for which most of the genes are unknown. The completion of various genome-sequencing projects and large-scale genomic studies has led to a wealth of available biological data. It is anticipated that this information will revolutionize our i ...
... of disorders for which numerous loci have been reported but for which most of the genes are unknown. The completion of various genome-sequencing projects and large-scale genomic studies has led to a wealth of available biological data. It is anticipated that this information will revolutionize our i ...
View poster
... genome sequencing (WGS) or targeted enrichment using exome or gene panels. Copy number variation (CNV) of genomic segments is a large category of structural variation and has been implicated in many Mendelian diseases and complex traits. The impact of CNVs on gene expression is not limited to only t ...
... genome sequencing (WGS) or targeted enrichment using exome or gene panels. Copy number variation (CNV) of genomic segments is a large category of structural variation and has been implicated in many Mendelian diseases and complex traits. The impact of CNVs on gene expression is not limited to only t ...
Homology - a persona..
... If there is more than one ortholog, which one is ‘correct’? There is a tendency to wish that there could be only one ortholog in an organism. This is frequently not the case. Figure 1 shows a gene tree. The A1 gene has three orthologs in species C. The nature of the subtype relationship depends sole ...
... If there is more than one ortholog, which one is ‘correct’? There is a tendency to wish that there could be only one ortholog in an organism. This is frequently not the case. Figure 1 shows a gene tree. The A1 gene has three orthologs in species C. The nature of the subtype relationship depends sole ...
Ingenuity Upstream Regulator Analysis in IPA®
... The goal of the IPA Upstream Regulator analytic is to identify the cascade of upstream transcriptional regulators that can explain the observed gene expression changes in a user’s dataset, which can help illuminate the biological activities occurring in the tissues or cells being studied. IPA mak ...
... The goal of the IPA Upstream Regulator analytic is to identify the cascade of upstream transcriptional regulators that can explain the observed gene expression changes in a user’s dataset, which can help illuminate the biological activities occurring in the tissues or cells being studied. IPA mak ...
Information Encoding in Biological Molecules: DNA and protein
... • Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. • In spite of recent progress, there are still uncertainties in diagnosis. Also, it is likely that the existing classes are heterogeneous. • DNA microarrays may be used to char ...
... • Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. • In spite of recent progress, there are still uncertainties in diagnosis. Also, it is likely that the existing classes are heterogeneous. • DNA microarrays may be used to char ...
User Manual
... and physical interactions among proteins within one or more complexes simultaneously and make sense out of it? The GIPro Plugin for Cytoscape is developed to analyze large-scale quantitative genetic interaction data statistically to identify functional relationships between genes and between protein ...
... and physical interactions among proteins within one or more complexes simultaneously and make sense out of it? The GIPro Plugin for Cytoscape is developed to analyze large-scale quantitative genetic interaction data statistically to identify functional relationships between genes and between protein ...
Review. Characterization and selection of hexaploid wheats
... pathotype, but is susceptible to two Swedish and one Australian pathotypes. Resistance to Ha71 is inherited as determined by a single dominant factor (Cre2) originally located in the N v genome (Delibes et al., 1993; Andrés et al., 2001). The Cre6 gene, characterized in collaboration with an Austral ...
... pathotype, but is susceptible to two Swedish and one Australian pathotypes. Resistance to Ha71 is inherited as determined by a single dominant factor (Cre2) originally located in the N v genome (Delibes et al., 1993; Andrés et al., 2001). The Cre6 gene, characterized in collaboration with an Austral ...
Genome Rearrangements Caused by Depletion of Essential DNA
... spontaneous DNA damage and genome rearrangements. Mapping, classification, and analysis of rearrangement breakpoints indicated that yeast fragile sites, Ty retrotransposons, tRNA genes, early origins of replication, and replication termination sites are common features at breakpoints when essential r ...
... spontaneous DNA damage and genome rearrangements. Mapping, classification, and analysis of rearrangement breakpoints indicated that yeast fragile sites, Ty retrotransposons, tRNA genes, early origins of replication, and replication termination sites are common features at breakpoints when essential r ...
N E W S A N D ...
... amounts of molecular and biochemical information gathered using the latest advances in biotechnology. Once the information is available, it can be modeled using computational and mathematical methods in the framework of population-level variability. For example, Davidson13 has provided a preliminary ...
... amounts of molecular and biochemical information gathered using the latest advances in biotechnology. Once the information is available, it can be modeled using computational and mathematical methods in the framework of population-level variability. For example, Davidson13 has provided a preliminary ...