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Is there a link between DNA and Obesity?
Is there a link between DNA and Obesity?

... Every gene is interrupted by a DNA strand known as an intron. Researchers discovered a “genetic switch” with in the FTO gene’s intron. If a human has the high obesity-risk variant gene, it affects the introns. The introns, when affected by this FTO gene variant, doubles the activity of two other gen ...
Topic Fifteen - Science - Miami
Topic Fifteen - Science - Miami

... Dawn of the "Genetics Age" May Help Those With Inherited Diseases "Designer Babies"? New Processes Let Parents Select Baby's Sex No Bull: Genetic Manipulation Lets Breeders Select for Female Cows Boy or Girl? Discovery of Genetic Process That Determines Embryo's ...


... of generation of extended gaps • Oligo method is robust to truncation and inversions • May be developed into a tool for analysis and comparison of very long sequences or complete genomes • (Preview lecture II): hints at how genomes grow ...
Plasmids - winterk
Plasmids - winterk

... They act as delivery vehicles, or vectors, to introduce foreign DNA into bacteria. Using plasmids for DNA delivery began in the 1970s when DNA from other organisms was first ‘cut and pasted’ into specific sites within the plasmid DNA. The modified plasmids were then reintroduced into bacteria. Decad ...
How to be a clinical geneticist
How to be a clinical geneticist

... • If we could stretch the DNA in a single cell it would measure 2 meters ...
The Ensembl Database
The Ensembl Database

... Nonetheless, this is useful for finding putative orthologs and for discovering regulatory regions using multiple sequence alignments ...
lec-4 - ucsf biochemistry website
lec-4 - ucsf biochemistry website

... Transposition elements: Pieces of DNA equipped with mechanisms that lead to their movement from one DNA sequence to another. They are considered selfish pieces of DNA that parasitize other replicating molecules. There are three modes of transposition, conservative (or cut and paste), replicative and ...
chapter 8 and 9
chapter 8 and 9

... Example: nitrous acid strips the amino group from nucleotides Base analogs Resemble nucleotide bases; erroneously incorporated into DNA Analog base-pairs with a different nucleotide Intercalating agents Insert between base-pairs, pushing nucleotides apart; extra nucleotide may then be erroneously ad ...
Sample Examination Questions for Exam 2 Material Warning!
Sample Examination Questions for Exam 2 Material Warning!

... Students are responsible for all of the material covered in lectures, assigned readings, textbook problems, laboratories, and any other assigned work. Since these samples have been taken from several past exams, some questions may be very similar or identical. On short answer, essay questions, and g ...
Co-‐evolution of the human genome and microbiome - EMBL-EBI
Co-‐evolution of the human genome and microbiome - EMBL-EBI

Dragon Genetics -- Independent Assortment and Gene
Dragon Genetics -- Independent Assortment and Gene

... This is a lab/activity that uses dragons as "research subjects" for genetics research. It highlights independent assortment as well as gene linkage. Students will do the first part of the activity using independent assortment (genes on different chromosomes). The second part of the activity looks at ...
Supplementary material 1 grimalt
Supplementary material 1 grimalt

Glenbard District 87 - Glenbard High School District 87
Glenbard District 87 - Glenbard High School District 87

... 12.11.12:    Understand  Mendel’s  Law  of  Segregation  and  also  that  genes  do  not  always  separate  as  hypothesized  by  Mendel’s  Law  of  Segregation.     Understand  that  if  genes  are  located  closely  together  on  the ...
Lesson 3 | DNA and Genetics
Lesson 3 | DNA and Genetics

... Scientists estimate that in some areas of Africa, up to 40 percent of the population carries at least one sickle-cell gene. Those people who carry two sickle cell genes, one from each parent, have sickle-cell disease. The mutation is most common in those parts of the continent that are hit hardest b ...
Chap 8 Recombinant DNA technology Fall 2012
Chap 8 Recombinant DNA technology Fall 2012

... Inoculate bacteria on media containing antibiotic. ...
TY_BSC lectures - Dhananjay bhole`s Virtual Home
TY_BSC lectures - Dhananjay bhole`s Virtual Home

... expressed by a genome. While the genome is static, the proteome continually changes in response to external and internal events.  Proteomics: The study of how the entire set of proteins produced by a particular organism interact  It encompasses the identification and quantification of proteins, an ...
幻灯片 1 - University of Texas at Austin
幻灯片 1 - University of Texas at Austin

... •The samples are run on an agarose gel, and the bands found at the crime scene are aligned with those of the suspects’. •DNA fingerprints can do two things, they can either prove someone’s innocence, or prove their guilt. The next example shows how DNA fingerprinting can point to a criminal. DNA sam ...
Distrofie muscolari dei cingoli
Distrofie muscolari dei cingoli

... degli Studi di Napoli ...
epigenetics of carcinogenesis
epigenetics of carcinogenesis

... In this study, we for the first time found that low dose radiation (LDR) exposure causes profound and tissue-specific epigenetic changes in the exposed tissues We established that LDR exposure affects methylation of repetitive elements in the genome, causes changes in histone methylation, acethylati ...
polymorphism
polymorphism

... As illustrated below, this exercise has four distinct steps. Since all four steps cannot be completed in one three hour session, the different steps will be completed over the course of several weeks. When working on any given step, it is a good idea to be aware of the overall exercise. Step one ext ...
101 -- 2006
101 -- 2006

... d) two pyrimidines. b) a purine and a pyrimidine. e) a sugar and a phosphate molecule. c) two purines. __ 3. Which of the following statements about DNA replication is NOT correct? a) Unwinding of the DNA molecule occurs as hydrogen bonds break. b) Replication occurs as each base is paired with anot ...
Genetic Transformation of Bacteria with pGLO
Genetic Transformation of Bacteria with pGLO

... adding the sugar arabinose to the cell’s nutrient medium. Selection for cells that have been transformed with pGLO DNA is accomplished by growth on antibiotic plates. ...
Genetic Fine Structure
Genetic Fine Structure

... of Bacteriophage T4. ...
file - UCL Discovery
file - UCL Discovery

... To perform synteny analysis, you will need to repeat the above analysis for equivalent regions in other species of interest. Once you have this done, you will have CTCF predicted results from all species. The next step is to look at synteny across these species to see whether the same set of genes i ...
PowerPoint 프레젠테이션
PowerPoint 프레젠테이션

... Recombination occurs at regions of homology between chromosomes through the breakage and reunion of DNA molecules. Models for recombination, such as the Holliday model, involve the creation of a heteroduplex branch, or cross bridge, that can migrate and the subsequent splicing of the intermediate s ...
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Genome editing

Genome editing, or genome editing with engineered nucleases (GEEN) is a type of genetic engineering in which DNA is inserted, replaced, or removed from a genome using artificially engineered nucleases, or ""molecular scissors."" The nucleases create specific double-stranded break (DSBs) at desired locations in the genome, and harness the cell’s endogenous mechanisms to repair the induced break by natural processes of homologous recombination (HR) and nonhomologous end-joining (NHEJ). There are currently four families of engineered nucleases being used: Zinc finger nucleases (ZFNs), Transcription Activator-Like Effector Nucleases (TALENs), the CRISPR/Cas system, and engineered meganuclease re-engineered homing endonucleases.It is commonly practiced in genetic analysis that in order to understand the function of a gene or a protein function one interferes with it in a sequence-specific way and monitors its effects on the organism. However, in some organisms it is difficult or impossible to perform site-specific mutagenesis, and therefore more indirect methods have to be used, such as silencing the gene of interest by short RNA interference (siRNA) . Yet gene disruption by siRNA can be variable and incomplete. Genome editing with nucleases such as ZFN is different from siRNA in that the engineered nuclease is able to modify DNA-binding specificity and therefore can in principle cut any targeted position in the genome, and introduce modification of the endogenous sequences for genes that are impossible to specifically target by conventional RNAi. Furthermore, the specificity of ZFNs and TALENs are enhanced as two ZFNs are required in the recognition of their portion of the target and subsequently direct to the neighboring sequences.It was chosen by Nature Methods as the 2011 Method of the Year.
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