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References - BioMed Central
... role in cell sterol metabolism: it may function to protect cells from overaccumulation of cholesterol This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type: it binds to Golgi membranes in a GTP-d ...
... role in cell sterol metabolism: it may function to protect cells from overaccumulation of cholesterol This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type: it binds to Golgi membranes in a GTP-d ...
Gene Section MERTK (c-mer proto-oncogene tyrosine kinase) Atlas of Genetics and Cytogenetics
... members, AXL and Tyro-3. Together, Tyro-3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (Linger et al., 2008). The extracellular domain of MERTK serves as the ligand binding region for the ligands GAS6 (Chen et al., 1997) and Protein S (Prasad et al., 2006). Specifically, Gas6 ...
... members, AXL and Tyro-3. Together, Tyro-3, Axl, and Mer constitute the TAM family of receptor tyrosine kinases (Linger et al., 2008). The extracellular domain of MERTK serves as the ligand binding region for the ligands GAS6 (Chen et al., 1997) and Protein S (Prasad et al., 2006). Specifically, Gas6 ...
01 Signal transduction
... Transducers and Activators of Transcription that function as DNAbinding factors to regulate gene expression. STAT3 can act as an oncogene, and its function has been shown to be critical for cellular transformation by a number of oncogenic tyrosine kinases. The role of STAT3 as a DNA-binding transcri ...
... Transducers and Activators of Transcription that function as DNAbinding factors to regulate gene expression. STAT3 can act as an oncogene, and its function has been shown to be critical for cellular transformation by a number of oncogenic tyrosine kinases. The role of STAT3 as a DNA-binding transcri ...
Neurogenic genes control gene expression at the transcriptional
... already noticed for the RNA, the domain of L’sc accumulation is the same as in earlier stages. Neurogenic gene function is required for the specification of the mesectoderm The mesectoderm forms during gastrulation, when two singlecell wide rows join at the ventral midline. In a stage 8 wildtype emb ...
... already noticed for the RNA, the domain of L’sc accumulation is the same as in earlier stages. Neurogenic gene function is required for the specification of the mesectoderm The mesectoderm forms during gastrulation, when two singlecell wide rows join at the ventral midline. In a stage 8 wildtype emb ...
Recent Advances in αβ T Cell Biology: Wnt Signaling
... controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. The canonical model requires the activation of the Notch receptor through a series of proteolytic events on binding to any of the Delta–Serrate–LAG2 (DSL) ligands. The crucial cleavage event for signaling depe ...
... controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. The canonical model requires the activation of the Notch receptor through a series of proteolytic events on binding to any of the Delta–Serrate–LAG2 (DSL) ligands. The crucial cleavage event for signaling depe ...
Structural Analysis and Functional Implications of
... FIGURE 3: REDD1 exhibits a novel topology and does not oligomerize. (A) Cartoon representation of the REDD189-226Δφ structure colored in rainbow mode from the N- to the C-terminus. The dotted line represents disordered region. The black arrowhead indicates the location of the FLPGF204 deletion. (B) ...
... FIGURE 3: REDD1 exhibits a novel topology and does not oligomerize. (A) Cartoon representation of the REDD189-226Δφ structure colored in rainbow mode from the N- to the C-terminus. The dotted line represents disordered region. The black arrowhead indicates the location of the FLPGF204 deletion. (B) ...
Phenotypic Modulation of Smooth Muscle Cells
... We then infected A7r5 cells with an adenovirus encoding Foxo4-TMN (Adtet-off-Foxo4-TMN) (Figures 2D and 2E). Twenty-four hours after infection, cells were serum starved and stimulated with IGF-I in the presence or absence of LY294002. Lysates were harvested 1 hr later for Western blot (Figure 2D) an ...
... We then infected A7r5 cells with an adenovirus encoding Foxo4-TMN (Adtet-off-Foxo4-TMN) (Figures 2D and 2E). Twenty-four hours after infection, cells were serum starved and stimulated with IGF-I in the presence or absence of LY294002. Lysates were harvested 1 hr later for Western blot (Figure 2D) an ...
Mutations within the propeptide, the primary cleavage site or the
... In order to investigate whether the propeptide contains a signal which must be removed before PC2 can pass through the secretory compartment, we next expressed a series of constructs containing deletions of regions in the propeptide. Expression of any of the mutants containing deletions between the ...
... In order to investigate whether the propeptide contains a signal which must be removed before PC2 can pass through the secretory compartment, we next expressed a series of constructs containing deletions of regions in the propeptide. Expression of any of the mutants containing deletions between the ...
Document
... In the plasma testosterone and DHT bind to two proteins1. Sex hormone binding globulin ( SHBG) binds 97 to 99% and 2. Testosterone-estrogen binding globulin( TEBG). A small fraction is in free form. Both these proteins are synthesized in liver. The plasma testosterone level in normal men is about 0. ...
... In the plasma testosterone and DHT bind to two proteins1. Sex hormone binding globulin ( SHBG) binds 97 to 99% and 2. Testosterone-estrogen binding globulin( TEBG). A small fraction is in free form. Both these proteins are synthesized in liver. The plasma testosterone level in normal men is about 0. ...
Molecular Physiology: Enzymes and Cell Signaling Proteins Binding
... (transduction) • signaling cascades – Signals passes from one intracellular carrier to another until an enzyme is activated – Behavior of cell changes ...
... (transduction) • signaling cascades – Signals passes from one intracellular carrier to another until an enzyme is activated – Behavior of cell changes ...
Slide 1
... fresh serum capable of lysing antibody (Ab)-coated cells. • This activity is destroyed (inactivated) by heating serum at 56 degrees C for 30 minutes. ...
... fresh serum capable of lysing antibody (Ab)-coated cells. • This activity is destroyed (inactivated) by heating serum at 56 degrees C for 30 minutes. ...
Mechanisms of Hormone Action: Peptide Hormones
... Receptor phosphorylation Effector proteins bind receptor - direct enzymatic function - STAT proteins STATs phosphorylated ...
... Receptor phosphorylation Effector proteins bind receptor - direct enzymatic function - STAT proteins STATs phosphorylated ...
Signal Transduction II
... o begins with autophosphorylated or transphosphorylated amino acids on the receptor o Phosphorylation recruits other proteins to the receptor o Amino acids surrounding the phosphorylation site determine which proteins are bound… 4 major protein interaction domains: ...
... o begins with autophosphorylated or transphosphorylated amino acids on the receptor o Phosphorylation recruits other proteins to the receptor o Amino acids surrounding the phosphorylation site determine which proteins are bound… 4 major protein interaction domains: ...
PEPTIDE HORMONES
... Sizes, origins and fate: Due to the force of custom, “peptide hormones” is a collective name that has been applied to peptides, polypeptides and proteins that all function as hormones. The name “factor” has also been given to some of these peptides and originates from a time when their peptide/prot ...
... Sizes, origins and fate: Due to the force of custom, “peptide hormones” is a collective name that has been applied to peptides, polypeptides and proteins that all function as hormones. The name “factor” has also been given to some of these peptides and originates from a time when their peptide/prot ...
Expression and purification of S100A12 and the V domain of
... until the optical density (OD) at 600 nm reached 0.7. Protein expression was induced by adding 1 mM isopropyl β-D-thiogalactopyranoside (IPTG) at 298 K. After 16 h of induction, the cells were centrifuged at 6,000 rpm for 25 min at 277 K, and then the cell pellets were suspended in 20 mL of buffer ( ...
... until the optical density (OD) at 600 nm reached 0.7. Protein expression was induced by adding 1 mM isopropyl β-D-thiogalactopyranoside (IPTG) at 298 K. After 16 h of induction, the cells were centrifuged at 6,000 rpm for 25 min at 277 K, and then the cell pellets were suspended in 20 mL of buffer ( ...
Biology of Cancer - Tunghai University
... 6.4 SH2 groups explain how growth factors activate Ras and acquire signaling ...
... 6.4 SH2 groups explain how growth factors activate Ras and acquire signaling ...
Bio3460-22 Hormones
... Fig. 1 Contrasting stomatal responses to exogenous ABA applied to diverse lineages of ...
... Fig. 1 Contrasting stomatal responses to exogenous ABA applied to diverse lineages of ...
Lozenge is expressed in pluripotent precursor cells
... emerge as 5-cell preclusters, while all cells that do not become part of the precluster undergo a synchronized round of mitosis and give rise to a pool of precursor cells that eventually differentiates into R1/R6, R7, cone, pigment and bristle cells (Ready et al., 1976; Wolff and Ready, 1991). How t ...
... emerge as 5-cell preclusters, while all cells that do not become part of the precluster undergo a synchronized round of mitosis and give rise to a pool of precursor cells that eventually differentiates into R1/R6, R7, cone, pigment and bristle cells (Ready et al., 1976; Wolff and Ready, 1991). How t ...
From pattern to gene, from gene to pattern
... to have organizing activity, these formerly abstract concepts examine the concepts of activator, selector, and realizator genes became visible realities. Furthermore, a whole new approach to in light of the current depth of information about these hierarchies. embryology was born. Rather than focus ...
... to have organizing activity, these formerly abstract concepts examine the concepts of activator, selector, and realizator genes became visible realities. Furthermore, a whole new approach to in light of the current depth of information about these hierarchies. embryology was born. Rather than focus ...
GeneAssist™ Pathway Atlas - Thermo Fisher Scientific
... Cell signaling, metabolic, and disease pathway maps are becoming increasingly intricate as more genes and proteins are mapped to cellular functions. As a result, there is a growing need to understand which pathways involve certain genes, as well as the interrelationships between the proteins within ...
... Cell signaling, metabolic, and disease pathway maps are becoming increasingly intricate as more genes and proteins are mapped to cellular functions. As a result, there is a growing need to understand which pathways involve certain genes, as well as the interrelationships between the proteins within ...
Transcriptional activation by the human herpesvirus-8
... T1.1, ORF K8 and vIL-6 genes was significantly lower than in untransfected BCBL-1 or BCBL-1\anti-vIL-6 cells, while the HHV-8 sVCA and cellular actin transcripts were unaffected (Li et al., 1998). The selective repression of specific HHV-8 gene expression in cells expressing antisense to vIRF sugges ...
... T1.1, ORF K8 and vIL-6 genes was significantly lower than in untransfected BCBL-1 or BCBL-1\anti-vIL-6 cells, while the HHV-8 sVCA and cellular actin transcripts were unaffected (Li et al., 1998). The selective repression of specific HHV-8 gene expression in cells expressing antisense to vIRF sugges ...
Actin dynamics - Journal of Cell Science
... The figure shows the dendritic nucleation hypothesis for the assembly of actin filament networks at the leading edge of motile cells (Pollard et al., 2000). In this model, the actinmonomer-binding protein profilin (shown in black), with help in vertebrate cells from thymosin β4 (not shown), maintain ...
... The figure shows the dendritic nucleation hypothesis for the assembly of actin filament networks at the leading edge of motile cells (Pollard et al., 2000). In this model, the actinmonomer-binding protein profilin (shown in black), with help in vertebrate cells from thymosin β4 (not shown), maintain ...
WHAT IS PROTEIN?
... the essential amino acids our bodies cannot make and are therefore vital in our diets in small amounts. By contrast, incomplete proteins, which come from mainly plant sources, can be combined to make a complete protein. WHY IS PROTEIN IMPORTANT IN YOUR DIET? Protein makes up the largest percentage o ...
... the essential amino acids our bodies cannot make and are therefore vital in our diets in small amounts. By contrast, incomplete proteins, which come from mainly plant sources, can be combined to make a complete protein. WHY IS PROTEIN IMPORTANT IN YOUR DIET? Protein makes up the largest percentage o ...
Full-Text PDF
... included MAPK1, SKIV2L2, Sec24D, Cct4, PDIA3, CORO1C. These proteins are involved in DNA transcription, mRNA translation, cell cycle, cell motility, and morphological processes. For the purposes of this study, those proteins involved in transcriptional and translational control were of particular in ...
... included MAPK1, SKIV2L2, Sec24D, Cct4, PDIA3, CORO1C. These proteins are involved in DNA transcription, mRNA translation, cell cycle, cell motility, and morphological processes. For the purposes of this study, those proteins involved in transcriptional and translational control were of particular in ...
Hedgehog signaling pathway
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The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.