![Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures Zheng Zhou](http://s1.studyres.com/store/data/008265200_1-6bca9ea3fafd30526b7606b3d8920853-300x300.png)
Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures Zheng Zhou
... SSRIs bind directly to the serotonin-transporter protein and inhibit neurotransmitter recycling, making them effective drugs for the treatment of depressive disorders1,2. SSRIs, however, are rather promiscuous in that they also bind to the homologous norepinephrine and dopamine transporters (NET and ...
... SSRIs bind directly to the serotonin-transporter protein and inhibit neurotransmitter recycling, making them effective drugs for the treatment of depressive disorders1,2. SSRIs, however, are rather promiscuous in that they also bind to the homologous norepinephrine and dopamine transporters (NET and ...
A novel exon within the mdm2 gene modulates translation
... al., 1997). The eect is independent of p53 since both wild type and p53 null mice were similarly aected. The mdm2 protein can be divided into sub-domains (reviewed by Piette et al., 1997). Human mdm2 is composed of 491 residues (see Figure 1) and interactions with p53 and E2F-1/DP1 occur within th ...
... al., 1997). The eect is independent of p53 since both wild type and p53 null mice were similarly aected. The mdm2 protein can be divided into sub-domains (reviewed by Piette et al., 1997). Human mdm2 is composed of 491 residues (see Figure 1) and interactions with p53 and E2F-1/DP1 occur within th ...
Use of mitochondrial electron transport mutants
... weeks, respectively, prior to the time at which the photograph was taken. The data discussed in this review were obtained by analysis of plants at a developmental stage corresponding to 10 d later than that shown in the photograph, when both genotypes are comparable in shoot size and leaf number. ...
... weeks, respectively, prior to the time at which the photograph was taken. The data discussed in this review were obtained by analysis of plants at a developmental stage corresponding to 10 d later than that shown in the photograph, when both genotypes are comparable in shoot size and leaf number. ...
Fern Gametophytes Grown under Different Light Spectra 1
... B-, and W-gametophytes, equal amounts of protein extracts were separated on SDS-PAGE gels. Thereafter the gels were blotted onto nitrocellulose filters and probed with polyclonal antibodies raised in rabbit against either SDS-treated spinach LSU or SSU. Figures 3 and 4 show typical immunoblots using ...
... B-, and W-gametophytes, equal amounts of protein extracts were separated on SDS-PAGE gels. Thereafter the gels were blotted onto nitrocellulose filters and probed with polyclonal antibodies raised in rabbit against either SDS-treated spinach LSU or SSU. Figures 3 and 4 show typical immunoblots using ...
Introduction to Baking
... 2. Amount of salt – Salt retards (slows) yeast and bacterial fermentation. – Salt is easily adjusted in a pre-ferment. • Pre-ferments are made and fermented before final dough is made up. Pre-ferments contain yeast and other ingredients from the formula. – For short fermentation, add a low amount of ...
... 2. Amount of salt – Salt retards (slows) yeast and bacterial fermentation. – Salt is easily adjusted in a pre-ferment. • Pre-ferments are made and fermented before final dough is made up. Pre-ferments contain yeast and other ingredients from the formula. – For short fermentation, add a low amount of ...
Platelet Dense Granule Membranes Contain Both
... P-selectin was present not only along the a-granule membranes but also along the membranes of granules labeled by D545 (Fig 4). However, D545 did not label a-granules. The double-labeled granules often appeared as empty vesicles on the frozen scctions, with no evidence of a dense core. Occasionally, ...
... P-selectin was present not only along the a-granule membranes but also along the membranes of granules labeled by D545 (Fig 4). However, D545 did not label a-granules. The double-labeled granules often appeared as empty vesicles on the frozen scctions, with no evidence of a dense core. Occasionally, ...
Abiotic stress in plants: Late Embryogenesis Abundant proteins Imen Amara
... plant ABA levels which induce the expression of stress-related genes and adaptive physiological responses (Cramer et al. 2011; Raghavendra et al. 2010). In seeds, ABA is a major factor regulating seed dormancy. ABA-deficient seeds as the viviparous mutants in maize show reduced dormancy whereas ove ...
... plant ABA levels which induce the expression of stress-related genes and adaptive physiological responses (Cramer et al. 2011; Raghavendra et al. 2010). In seeds, ABA is a major factor regulating seed dormancy. ABA-deficient seeds as the viviparous mutants in maize show reduced dormancy whereas ove ...
Kinetic Role of Helix Caps in Protein Folding Is Context
... tetrameric native state (28). A range of kinetic effects has also been seen in single amino acid mutations at both helix ends in several other proteins (3, 5, 6). The monomeric λ repressor protein (λ6-85) is one of the fastest folding proteins known (29). It is small and helical, with short loops, h ...
... tetrameric native state (28). A range of kinetic effects has also been seen in single amino acid mutations at both helix ends in several other proteins (3, 5, 6). The monomeric λ repressor protein (λ6-85) is one of the fastest folding proteins known (29). It is small and helical, with short loops, h ...
Deciphering the molecular basis of the specificity of protein
... determine their amino acid preferences. Two datasets have been examined. Firstly, one composed of non-covalently bound carbohydrates ligands. The results of this analysis is compared to the second dataset, obtained from the study of the spatial vicinity of the monosaccharides that form the common st ...
... determine their amino acid preferences. Two datasets have been examined. Firstly, one composed of non-covalently bound carbohydrates ligands. The results of this analysis is compared to the second dataset, obtained from the study of the spatial vicinity of the monosaccharides that form the common st ...
Structural and Biochemical Characterization of a Bifunctional
... in place of dTDP-Fuc3N. Both of the dTDP-Fuc3N and dTDP-Qui3N substrates required for these assays were prepared according to previously published procedures.17 The assays did, indeed, demonstrate that FdtD can function on both sugars that differ in stereochemistry about the C-4′ position. Kinetic An ...
... in place of dTDP-Fuc3N. Both of the dTDP-Fuc3N and dTDP-Qui3N substrates required for these assays were prepared according to previously published procedures.17 The assays did, indeed, demonstrate that FdtD can function on both sugars that differ in stereochemistry about the C-4′ position. Kinetic An ...
Full-Text PDF
... in the common ancestor of the Thermus-Deinococcus clade [5]. In thermophilic archaea, the helicase HerA is an essential enzyme encoded in a UV-induced operon that includes a NurA nuclease and DNA repair protein homologs to the eukaryotic Mre11 and Rad50 proteins. These eukaryotic Mre11 and Rad50 cou ...
... in the common ancestor of the Thermus-Deinococcus clade [5]. In thermophilic archaea, the helicase HerA is an essential enzyme encoded in a UV-induced operon that includes a NurA nuclease and DNA repair protein homologs to the eukaryotic Mre11 and Rad50 proteins. These eukaryotic Mre11 and Rad50 cou ...
Bacteria under stress by complement and coagulation
... note, activation of the AP can also occur at a low-level via the spontaneous ‘tick-over’ process in which hydrolysis of C3 creates the C3b-like molecule C3H2O (Pangburn et al., 1981; Ricklin et al., 2010). This activation process is down regulated on host cells but quickly amplified on bacterial cel ...
... note, activation of the AP can also occur at a low-level via the spontaneous ‘tick-over’ process in which hydrolysis of C3 creates the C3b-like molecule C3H2O (Pangburn et al., 1981; Ricklin et al., 2010). This activation process is down regulated on host cells but quickly amplified on bacterial cel ...
The Wine Expert: Fermentation of Fructose
... the yeast were phenotypically characterized, the genotype was also studied. The genes for Hexokinase I and Hexokinase II were sequenced since it was assumed that these two enzymes have key functions. Within the coding region of Hexokinase I it was determined that a mutation occured at position 513 w ...
... the yeast were phenotypically characterized, the genotype was also studied. The genes for Hexokinase I and Hexokinase II were sequenced since it was assumed that these two enzymes have key functions. Within the coding region of Hexokinase I it was determined that a mutation occured at position 513 w ...
Prokaryotic proteins of antioxidant defense in Trichomonas vaginalis
... Three classes of SODs based on amino acid sequence homology are recognized to this date (Fig. 1) (22,73,104,117): ...
... Three classes of SODs based on amino acid sequence homology are recognized to this date (Fig. 1) (22,73,104,117): ...
Mechanisms and applications of disulfide bond formation
... Disulfide bonds are covalent linkages formed between two cysteine residues in proteins as a result of oxidation reactions. Disulfide bonds are a crucial post translational modification for most secreted proteins and outer membrane proteins. Most of them require disulfide bonds for their stability, f ...
... Disulfide bonds are covalent linkages formed between two cysteine residues in proteins as a result of oxidation reactions. Disulfide bonds are a crucial post translational modification for most secreted proteins and outer membrane proteins. Most of them require disulfide bonds for their stability, f ...
Understanding the acetylome: translating targeted
... interaction and the consequence of this adaptive response in metabolic regulation. However, as with any study utilizing reductionist approaches, it was still unclear whether acetylation could command such a dramatic level of regulation in higher organisms in which substrate partitioning has a vastly ...
... interaction and the consequence of this adaptive response in metabolic regulation. However, as with any study utilizing reductionist approaches, it was still unclear whether acetylation could command such a dramatic level of regulation in higher organisms in which substrate partitioning has a vastly ...
Structure and Expression of Genes for a Class of Cysteine
... Figure 2. Sequence of the human UHS keratin gene. (A) The DNA sequence of the 1.0-kb Eco [ ] fragment containing the human UHS keratin gene is shown. The derived protein sequence of the gene appears above the DNA sequence. The predicted protein of 168 amino acids contains 36 mol% cysteine. The CCAA ...
... Figure 2. Sequence of the human UHS keratin gene. (A) The DNA sequence of the 1.0-kb Eco [ ] fragment containing the human UHS keratin gene is shown. The derived protein sequence of the gene appears above the DNA sequence. The predicted protein of 168 amino acids contains 36 mol% cysteine. The CCAA ...
insect transmitted plant pathogenic mollicutes, spiroplasma kunkelii
... transmission and plant pathogenicity that are missing from the animal and human pathogenic mycoplasmas. To test this hypothesis, comparative genome analysis among mollicutes was conducted, and resulted in the identification of four genes that are present in the genomes of all plant-pathogenic molli ...
... transmission and plant pathogenicity that are missing from the animal and human pathogenic mycoplasmas. To test this hypothesis, comparative genome analysis among mollicutes was conducted, and resulted in the identification of four genes that are present in the genomes of all plant-pathogenic molli ...
LNBI 9043 - Lupin Allergy: Uncovering Structural Features and
... FASTA alignment in the Structural Database of Allergenic Proteins (SDAP) (Fermi.utmb.edu/SDAP). Allergenicity profile was assessed by combination of different parameters: hydrophobicity, antigenicity and SASA [9]. Values of absolute surface area (ASA) of each residue were also calculated by DSSP pro ...
... FASTA alignment in the Structural Database of Allergenic Proteins (SDAP) (Fermi.utmb.edu/SDAP). Allergenicity profile was assessed by combination of different parameters: hydrophobicity, antigenicity and SASA [9]. Values of absolute surface area (ASA) of each residue were also calculated by DSSP pro ...
The Plasma Membrane - Beck-Shop
... Clearly, the role of plasma membranes in regulating some of the cellular activities remains to be established. For additional information, see Funnell, 1996.35 ...
... Clearly, the role of plasma membranes in regulating some of the cellular activities remains to be established. For additional information, see Funnell, 1996.35 ...
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... 2. Amount of salt – Salt retards (slows) yeast and bacterial fermentation. – Salt is easily adjusted in a pre-ferment. • Pre-ferments are made and fermented before final dough is made up. Pre-ferments contain yeast and other ingredients from the formula. – For short fermentation, add a low amount of ...
... 2. Amount of salt – Salt retards (slows) yeast and bacterial fermentation. – Salt is easily adjusted in a pre-ferment. • Pre-ferments are made and fermented before final dough is made up. Pre-ferments contain yeast and other ingredients from the formula. – For short fermentation, add a low amount of ...
MasterThesis_Ulvestad
... concentration dependence and saturation of uptake was difficult to obtain even if a time dependent uptake was recorded. The inconsistent results with atorvastatin and pravastatin could be due to the higher lipophilicity and greater extent of passive diffusion compared to ...
... concentration dependence and saturation of uptake was difficult to obtain even if a time dependent uptake was recorded. The inconsistent results with atorvastatin and pravastatin could be due to the higher lipophilicity and greater extent of passive diffusion compared to ...
Lipid II: A central component in bacterial cell wall synthesis and a
... Typical bacterial membrane lipids have alkyl chains as hydrophobic moieties. However, the bactoprenols, being polyisoprenoids, are rare but functionally very important constituents of the hydrophobic interior of the bacterial membrane. This immediately raises the question as to why bactoprenol acts ...
... Typical bacterial membrane lipids have alkyl chains as hydrophobic moieties. However, the bactoprenols, being polyisoprenoids, are rare but functionally very important constituents of the hydrophobic interior of the bacterial membrane. This immediately raises the question as to why bactoprenol acts ...
Nonsense-mediated mRNA decay - Case Western Reserve University
... nuclear and cytoplasmic mRNA levels, suggesting either that translation and NMD can occur in the nucleus, or that there is feedback following cytoplasmic NMD. In yeast, and possibly mammals, discrete cytoplasmic foci, referred to as P-bodies, have been identified, in which normal decapping and 50 -t ...
... nuclear and cytoplasmic mRNA levels, suggesting either that translation and NMD can occur in the nucleus, or that there is feedback following cytoplasmic NMD. In yeast, and possibly mammals, discrete cytoplasmic foci, referred to as P-bodies, have been identified, in which normal decapping and 50 -t ...
Extreme sweetness: protein glycosylation in archaea
... ago, detailed insights into this process have become possible only recently, with the availability of complete genome sequences for almost 200 archaeal species and the development of appropriate molecular tools. As a result of these advances, recent efforts have not only succeeded in delineating the ...
... ago, detailed insights into this process have become possible only recently, with the availability of complete genome sequences for almost 200 archaeal species and the development of appropriate molecular tools. As a result of these advances, recent efforts have not only succeeded in delineating the ...