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Full Text
Full Text

... sure specific characteristics of a biological system (e.g., the sequence of a gene or its level of expression) in a high-throughput manner, opening the possibility of automated functional identification. Automated functional identification is based on the principle of functional similarity, such tha ...
Molecular characterization of carnitinedependent transport of
Molecular characterization of carnitinedependent transport of

... was strongly impaired. To establish whether Yor100cp functions as the yeast carnitine acylcarnitine translocase as predicted from its similarity to the human protein, we studied the oxidation of 1-14C-labelled oleate in wild-type cells and deletion mutants. As shown in Figure 3, oxidation of [1-14C] ...
PDF - BMC Genomics
PDF - BMC Genomics

... Proteins are composed of smaller building blocks, which are called “domains” or “modules”. These building blocks are distinct regions in three-dimensional (3D) structure resulting in protein architectures assembled from modular segments that have evolved independently [3]. The modular nature of prot ...
Genetic Analysis of the Large Subunit of Yeast Transcription Factor
Genetic Analysis of the Large Subunit of Yeast Transcription Factor

... first class causes thermosensitive growth due to single amino acid substitutions of the cysteines comprising the Zn-binding motif. The second mutant class is made up of proteins that are C-terminally truncated and that cause a cold-sensitive growth phenotype. The behavior of these mutants suggests t ...
evaluation of cirrhosis liver disease via protein-protein
evaluation of cirrhosis liver disease via protein-protein

... the new techniques in research of modern world that analysis high throughput data in few time(17). Enrichment analysis of the interest proteins can be helpful in understanding the significant intricate parts of the cells and the underling mechanism of the disease pathology (18, 19). In this study, t ...
PROTEINS
PROTEINS

... This indicator is based on the assumption that more nitrogen is retained when the essential amino acids are present in sufficient amounts to meet the needs for growth. A food with a biological value of 70 or more is considered capable of supporting growth. The higher the biological value the better ...
Last update: 06/22/2015
Last update: 06/22/2015

... by >) followed by the one letter amino acid sequence. The definition line varies but often contains the GenInfo number (gi|4557715 – unique for each version of the sequence), database source and accession number (ref|NP_000221.1 for RefSeq) and the gene name and the organism. Copy the sequence inclu ...
Milk Protein - AgroMedia International Inc
Milk Protein - AgroMedia International Inc

Sequence-Specific Resonance Assignments of the `H
Sequence-Specific Resonance Assignments of the `H

... as the simian immunodeficiency virus (SIV), the bovine immunodeficiency virus (BIV), the feline immunodeficiency virus (FIV), the sheep visna virus (VILV), the caprine arthritis encephalitisvirus (CAEV), and the ovine lentivirus (OMVV). Retroviruses use a complex machinery of RNA-binding proteins to ...
The intracellular cyanobacteria of Paulinella chromatophora
The intracellular cyanobacteria of Paulinella chromatophora

... empirical data indicate that at least some modern endosymbionts are already well into such a transitional process. Peculiar endosymbionts or new organelles? Many insects harbor intracellular bacteria that produce and excrete essential amino acids into the host cytosol [10,11]. Although, in some case ...
A statistical physics perspective on alignment-independent pro
A statistical physics perspective on alignment-independent pro

... The value of individual propensity plots is limited. It works well, say, for predicting transmembrane regions within proteins, where peaks in the plot can correlate well with regions highly enriched in hydrophobic residues. Hitherto, it has proved difficult to interpret such plots other than by a pe ...
Last update: 06/22/2015 Page 1 of 7 Introduction to BLAST using
Last update: 06/22/2015 Page 1 of 7 Introduction to BLAST using

... by >) followed by the one letter amino acid sequence. The definition line varies but often contains the GenInfo number (gi|4557715 – unique for each version of the sequence), database source and accession number (ref|NP_000221.1 for RefSeq) and the gene name and the organism. Copy the sequence inclu ...
π- Stacking Interaction
π- Stacking Interaction

... structure, which is restricted by the allowed geometry of - stacking. • Followed by a stepwise addition of further monomers containing the same recognition elements. • Again, the overall structural organization of the addition process is being directed by the restricted geometries of the stacking in ...
I + rel + - UCSF Biochemistry & Biophysics
I + rel + - UCSF Biochemistry & Biophysics

... • i.e. crp mutants show no response to cyclic AMP - the receptor is inactive without cyclic AMP • i.e. adenyl cyclase mutants = crp mutants ...
Molecular and General Genetics
Molecular and General Genetics

... a further 55 residues can be matched if 4 gaps are introduced in both sequences. Nearby of areas 100% homology were detected in the central and the C-terminal parts of the proteins. In contrast, only relatively weak similarity was found in the N-terminal end of the mature protein of beta-l,3-1,4-glu ...
Erlanson et al. PNAS - UCSF Macromolecular Structure Group
Erlanson et al. PNAS - UCSF Macromolecular Structure Group

... of members) to identify modest affinity leads (Kd⬇1 to 10 ␮M). Although some targets are well suited for this screening process, most are problematic because moderate affinity leads are difficult to obtain. Identifying and subsequently optimizing weaker binding compounds would improve the success ra ...
DNA-Bound Fos Proteins Activate Transcription in Yeast
DNA-Bound Fos Proteins Activate Transcription in Yeast

... Based on these experiments, we think it likely that “transactivation” of transfected gene expression by Fos (and perhaps by Myc) requires a direct interaction between the protein and the promoters of the activated genes. However, it is possible that some or all of these proteins’ promoter binding sp ...
Non-natural amino acid
Non-natural amino acid

... Only 20 amino acids are used in the biosynthesis of proteins no fundamental reason other amino acids cannot be used in proteins ...
Not just another hole in the wall: understanding intercellular protein
Not just another hole in the wall: understanding intercellular protein

... the endodermal cell layer and normal patterning of the root (Helariutta et al. 2000). Recently, SHR movement was shown to be dependent upon its presence in the cytoplasm (Gallagher et al. 2004). SHR is expressed in stele cells in the Arabidopsis root meristem. In these cells the SHR protein localize ...
Towards the Discovery of New Antimicrobials: the Bifunctional
Towards the Discovery of New Antimicrobials: the Bifunctional

Incorporating GENETAG-style annotation to GENIA corpus
Incorporating GENETAG-style annotation to GENIA corpus

... corpus revisions described in this work are two-fold. First, annotation for the abstract entity, gene, were added (Table 1, GGP). To emphasize the characteristics of the new entity type, which does not distinguish a gene and its products, we call it GGP (gene or gene product). Second, the addition o ...
Nerve activates contraction
Nerve activates contraction

... from body cells to the liver for breakdown; are increased by exercise, and limited coffee, smoking, and saturated fats/trans fats  Healthy Ratios in the Blood ...
Lecture slides
Lecture slides

... associated with a phenotype in the “Online Mendelian Inheritance in Man” (OMIM) database, have not yet been identified (Hamosh, Scott et al. 2005). Evidently disease gene identification continues to be a very strenuous challenge, since mutational analysis of hundreds of candidates in a critical inte ...
Comparative Analysis of Plant and Animal Calcium Signal
Comparative Analysis of Plant and Animal Calcium Signal

... The numbers of calcium signal transduction genes in rice were classified by using the InterPro database at standard conditions. Results Calcium Transport Proteins The Ca21 concentrations on both sides of the cell membrane are precisely regulated by transport proteins (channels, pumps, and transporte ...
Structural analysis of GARP
Structural analysis of GARP

... Choowongkomon et al. (2005), J. Biol. Chem. ...
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Magnesium transporter

This page links directly from the magnesium in biological systems page.Magnesium transporters are proteins that transport magnesium across the cell membrane. All forms of life require magnesium, yet the molecular mechanisms of Mg2+ uptake from the environment and the distribution of this vital element within the organism are only slowly being elucidated.In bacteria, Mg2+ is probably mainly supplied by the CorA protein and, where the CorA protein is absent, by the MgtE protein. In yeast the initial uptake is via the Alr1p and Alr2p proteins, but at this stage the only internal Mg2+ distributing protein identified is Mrs2p. Within the protozoa only one Mg2+ transporter (XntAp) has been identified. In metazoa, Mrs2p and MgtE homologues have been identified, along with two novel Mg2+ transport systems TRPM6/TRPM7 and PCLN-1. Finally, in plants, a family of Mrs2p homologues has been identified along with another novel protein, AtMHX.
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