Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ
... Users, particularly teenagers, claim the drug is not addictive, but its potential abuse is not known. Salvinorin A is a potent and highly selective κ-agonist, with greater efficacy than that of the synthetic κ-agonist U-50488 and U-69593, as revealed by binding studies (Roth et al. 2002; Sheffler an ...
... Users, particularly teenagers, claim the drug is not addictive, but its potential abuse is not known. Salvinorin A is a potent and highly selective κ-agonist, with greater efficacy than that of the synthetic κ-agonist U-50488 and U-69593, as revealed by binding studies (Roth et al. 2002; Sheffler an ...
Block of Delayed-Rectifier Potassium Channels by Reduced
... R-haloperidol has higher concentrations in the human brain than haloperidol, we focused on this metabolite for the rest of the study. Sidedness of R-Haloperidol Block. Potassium channels possess multiple drug binding sites, and some are only accessible from one side of the plasma membrane. R-haloper ...
... R-haloperidol has higher concentrations in the human brain than haloperidol, we focused on this metabolite for the rest of the study. Sidedness of R-Haloperidol Block. Potassium channels possess multiple drug binding sites, and some are only accessible from one side of the plasma membrane. R-haloper ...
Pharmacology
... E. Be used without development of tolerance 1306. Psychiatric evaluation of a patient after 6 weeks of treatment with a monoamine oxidase inhibitor 1311. Which one of the following statements about cocaine is (MAOI) shows no improvement. The psychiatrist now false? writes a prescription for fluoxeti ...
... E. Be used without development of tolerance 1306. Psychiatric evaluation of a patient after 6 weeks of treatment with a monoamine oxidase inhibitor 1311. Which one of the following statements about cocaine is (MAOI) shows no improvement. The psychiatrist now false? writes a prescription for fluoxeti ...
Pharmacological strategies for detoxification
... withdrawal-related insomnia. It is effective for users where dependence is uncertain, for younger people or for those who have a shorter drug history. It can be used for the first 7–10 days of detoxification with a starting dose of 800μg day−1 (usually four divided doses, due to a short half-life), ...
... withdrawal-related insomnia. It is effective for users where dependence is uncertain, for younger people or for those who have a shorter drug history. It can be used for the first 7–10 days of detoxification with a starting dose of 800μg day−1 (usually four divided doses, due to a short half-life), ...
Interactive Association of Drugs Binding to Human
... metals and toxic metabolites [1–6]. Additionally, there is a wide variety of drugs that are delivered to their targeting organs/tissues by binding with HSA [1,7–9]. Therefore, HSA not only protects the bound drugs against oxidation and influences the in vivo drug distribution, but also alters the ph ...
... metals and toxic metabolites [1–6]. Additionally, there is a wide variety of drugs that are delivered to their targeting organs/tissues by binding with HSA [1,7–9]. Therefore, HSA not only protects the bound drugs against oxidation and influences the in vivo drug distribution, but also alters the ph ...
Binding of Imipramine to Phospholipid Bilayers Using
... The tendency to refer to the result of drug-lipid bilayer interaction as “binding” has been subject to discussion because of the general meaning of this term in the classic enzyme-substrate or ligand-receptor interaction studies (Heirwegh et al. 1992). Binding into a bilayer is considered a restrict ...
... The tendency to refer to the result of drug-lipid bilayer interaction as “binding” has been subject to discussion because of the general meaning of this term in the classic enzyme-substrate or ligand-receptor interaction studies (Heirwegh et al. 1992). Binding into a bilayer is considered a restrict ...
Beta adrenergic influence on oesophageal peristalsis
... The effects of the beta-1 adrenergic agonist prenalterol and the beta-2 adrenergic agonist terbutaline on oesophageal peristalsis were studied in nine healthy volunteers with pressures recorded in the proximal, middle, and distal oesophagus. Two doses of the agonists were given after pretreatment wi ...
... The effects of the beta-1 adrenergic agonist prenalterol and the beta-2 adrenergic agonist terbutaline on oesophageal peristalsis were studied in nine healthy volunteers with pressures recorded in the proximal, middle, and distal oesophagus. Two doses of the agonists were given after pretreatment wi ...
Structural Basis for Pharmacology of Voltage
... Remarkably, as also predicted by the modulated receptor hypothesis (Hille, 1977), fenestrations lead from the lipid phase of the membrane sideways into the drug receptor site, providing a specific hydrophobic access pathway for binding of small hydrophobic drugs in the resting state of the channel ( ...
... Remarkably, as also predicted by the modulated receptor hypothesis (Hille, 1977), fenestrations lead from the lipid phase of the membrane sideways into the drug receptor site, providing a specific hydrophobic access pathway for binding of small hydrophobic drugs in the resting state of the channel ( ...
MK-801 Limits Neurovascular Dysfunction during Experimental
... in MS and EAE remain unclear, investigations in nonimmune models of neurovascular damage have identified central nervous system (CNS)-derived polyamines and the nitrogen intermediate nitric oxide (NO) as primary mediators of cerebral vessel disruption (Koenig et al., 1983a; Trout et al., 1986; Farac ...
... in MS and EAE remain unclear, investigations in nonimmune models of neurovascular damage have identified central nervous system (CNS)-derived polyamines and the nitrogen intermediate nitric oxide (NO) as primary mediators of cerebral vessel disruption (Koenig et al., 1983a; Trout et al., 1986; Farac ...
Hypoglossal Nerve Response to 5-HT3 Drugs Injected into the XII
... transducer model) and drug and fluid administration, respectively. The vagi were exposed and transected at the level of the third tracheal ring. Both XII nerves were dissected and transected at the level of the ramification into medial and lateral branches. The proximal ends of both XII nerves were ...
... transducer model) and drug and fluid administration, respectively. The vagi were exposed and transected at the level of the third tracheal ring. Both XII nerves were dissected and transected at the level of the ramification into medial and lateral branches. The proximal ends of both XII nerves were ...
GPCR endocytosis confers uniformity in responses to chemically
... recognized that there are multiple sources of functional diversity at GPCRs, involving not only equilibrium affinity and intrinsic efficacy of the drug, but also kinetics of the drug-GPCR interaction and an extended theoretical formulation of intrinsic efficacy that is now called functional selectiv ...
... recognized that there are multiple sources of functional diversity at GPCRs, involving not only equilibrium affinity and intrinsic efficacy of the drug, but also kinetics of the drug-GPCR interaction and an extended theoretical formulation of intrinsic efficacy that is now called functional selectiv ...
Ibogaine
... Ibogaine binds to Serotonin transporter and increases Serotonin levels in the NAc Noribogaine binds x 10 strongly than Ibogaine . Some suggest I. May reduced Dopamine secretion through Serotonin activity in the NAc ...
... Ibogaine binds to Serotonin transporter and increases Serotonin levels in the NAc Noribogaine binds x 10 strongly than Ibogaine . Some suggest I. May reduced Dopamine secretion through Serotonin activity in the NAc ...
UTEROTONIC PROPERTIES OF NYMPHAEA ALBA ON ISOLATED MYOMETRIUM MODEL Original Article
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
... (Nymphaeaceae) occurs in temperate and tropical regions. There are approximately 50species in this genus. Most are aquatic herbs, which are widely distributed in India, from Bengal, Orissa to Kashmir in lakes and ponds. The roots have also been used extensively in a variety of folk medicine. The dri ...
Fragment-Based Drug Discovery Applied to Hsp90
... Results and Discussion Fragment Screening for Hsp90. Approximately 1600 compounds from our fragment library43 were screened in cocktails using ligand observed NMR via water LOGSY.44 Compounds showing a medium or strong LOGSY signal (as defined in the Experimental Section) were further characterized ...
... Results and Discussion Fragment Screening for Hsp90. Approximately 1600 compounds from our fragment library43 were screened in cocktails using ligand observed NMR via water LOGSY.44 Compounds showing a medium or strong LOGSY signal (as defined in the Experimental Section) were further characterized ...
The role of medicine in respiratory diseases
... Learning Objectives The students understand the drugs that act on the respiratory system include – Bronchodilators – Corticosteroids – Cromoglycates – Leukotriene receptor antagonists – Antihistamines – Cough preparations – Nasal decongestants ...
... Learning Objectives The students understand the drugs that act on the respiratory system include – Bronchodilators – Corticosteroids – Cromoglycates – Leukotriene receptor antagonists – Antihistamines – Cough preparations – Nasal decongestants ...
myostimulant effect of leaves of cassia occidentalis
... The aqueous extract of Cassia occidentalis (Cesalpiniaceae) contains gallic tannins, alkaloids, sterols and polyterpenes, polyphenols, flavonoids and saponosides. The richness of this plant in secondary compounds with various pharmacological effects explains its ‘‘quenching’’ effect which is observe ...
... The aqueous extract of Cassia occidentalis (Cesalpiniaceae) contains gallic tannins, alkaloids, sterols and polyterpenes, polyphenols, flavonoids and saponosides. The richness of this plant in secondary compounds with various pharmacological effects explains its ‘‘quenching’’ effect which is observe ...
Histamine in Atopic Disorders: Atopic Dermatitis and
... of the H4 receptor also inhibits the antigen-specific human T cell responses by decreased IFN-g and IL-5 expression (Sugata et al., 2007). Th17 cells, another important subtype of T cells, also express the H4 receptor. Th17 cells are increased in peripheral blood of AD patients and play a potential ...
... of the H4 receptor also inhibits the antigen-specific human T cell responses by decreased IFN-g and IL-5 expression (Sugata et al., 2007). Th17 cells, another important subtype of T cells, also express the H4 receptor. Th17 cells are increased in peripheral blood of AD patients and play a potential ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.