Effects of risperidone, amisulpride and nicotine on eye
... schizophrenia patients (Burke and Reveley 2002; Harris et al. 2006) but deteriorate it in control participants (Barrett et al. 2004). It is hypothesised that RIS displays advantageous effects in high schizotypes and disadvantageous effects in medium schizotypes for AS performance. 3. AMI is an atypi ...
... schizophrenia patients (Burke and Reveley 2002; Harris et al. 2006) but deteriorate it in control participants (Barrett et al. 2004). It is hypothesised that RIS displays advantageous effects in high schizotypes and disadvantageous effects in medium schizotypes for AS performance. 3. AMI is an atypi ...
patrick_tb_ch22
... What physical feature other than logP is important to the activity of cimetidine analogues? Feedback: To be precise, the orientation of the dipole moment is important to the activity rather than the size of the dipole moment. Page reference: 660 a. Hydrophobicity b. Basicity ...
... What physical feature other than logP is important to the activity of cimetidine analogues? Feedback: To be precise, the orientation of the dipole moment is important to the activity rather than the size of the dipole moment. Page reference: 660 a. Hydrophobicity b. Basicity ...
Treatment of opioid-induced gut dysfunction
... animals; however, analysis of the cellular mechanisms of opiate action has shown that opioid receptor agonists can interrupt both excitatory and inhibitory neural inputs to the GI muscle in both human and animal models [21]. Inhibition of excitatory neural inputs is associated with inhibition of the ...
... animals; however, analysis of the cellular mechanisms of opiate action has shown that opioid receptor agonists can interrupt both excitatory and inhibitory neural inputs to the GI muscle in both human and animal models [21]. Inhibition of excitatory neural inputs is associated with inhibition of the ...
DESIGNING OF POTENTIAL NEW ESTROGEN ANTAGONISTS FOR TREATMENT OF
... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
... It has become a chronic disease nowadays and it can be controlled by estrogen antagonist as estrogen antagonist inhibits the action of estrogen and proliferation of endometrial cell is stopped [6, 13, 18]. The discovery of the first design of Estrogen antagonist drug has inspired a number of continu ...
Coadministration of Galanin Antagonist M40 with a Muscarinic M1
... Bethesda, Maryland 20982, and 2Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 ...
... Bethesda, Maryland 20982, and 2Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 ...
Discovery of PF-04457845: A Highly Potent
... the undesirable side effects observed with direct cannabinoid receptor agonists, indicating that FAAH may represent an attractive therapeutic target for the treatment of inflammatory pain and other nervous system disorders. Herein, we report the discovery and characterization of a highly efficacious ...
... the undesirable side effects observed with direct cannabinoid receptor agonists, indicating that FAAH may represent an attractive therapeutic target for the treatment of inflammatory pain and other nervous system disorders. Herein, we report the discovery and characterization of a highly efficacious ...
GPCR ontology: development and application of a G protein
... Analysis was initially performed per single screening campaign with compound categories defined as follows: an ‘active’ compound was one reported efficacious in primary and confirmatory assays annotated in the class assay stage in the ontology and activity outcome ‘active/probe’ in PubChem. These co ...
... Analysis was initially performed per single screening campaign with compound categories defined as follows: an ‘active’ compound was one reported efficacious in primary and confirmatory assays annotated in the class assay stage in the ontology and activity outcome ‘active/probe’ in PubChem. These co ...
Cannabinoids and the skeleton: From marijuana to reversal of bone
... share 44% overall identity (68% identity for the transmembrane domains). CB1 is perhaps the most abundantly expressed G protein-coupled receptor in the central nervous system. It is also present in peripheral neurons and the gonads and to some extent in several other peripheral tissues. CB2 is expre ...
... share 44% overall identity (68% identity for the transmembrane domains). CB1 is perhaps the most abundantly expressed G protein-coupled receptor in the central nervous system. It is also present in peripheral neurons and the gonads and to some extent in several other peripheral tissues. CB2 is expre ...
Acquisition of Nicotine Discrimination and Discriminative Stimulus
... 1988) and monkeys (Howell and Landrum, 1997). Acute pretreatment with caffeine also produced significant increases in rates of responding for i.v. nicotine self-administration in squirrel monkeys (Yasar et al., 1997). Caffeine, however, is consumed chronically by humans, and behavioral responses to ...
... 1988) and monkeys (Howell and Landrum, 1997). Acute pretreatment with caffeine also produced significant increases in rates of responding for i.v. nicotine self-administration in squirrel monkeys (Yasar et al., 1997). Caffeine, however, is consumed chronically by humans, and behavioral responses to ...
Reward Processing by the Opioid System in the Brain
... no visible cell bodies (obvious for POMC). These discrepancies between peptide and cell body maps, assessed by the same IR technique, suggest that an important proportion of opioid peptides is released by projecting neurons. Altogether, the anatomical studies show widespread expression of most compo ...
... no visible cell bodies (obvious for POMC). These discrepancies between peptide and cell body maps, assessed by the same IR technique, suggest that an important proportion of opioid peptides is released by projecting neurons. Altogether, the anatomical studies show widespread expression of most compo ...
Marijuana: What you need to know
... Research indicates that students do not remember what they have learned when they are “high”. “It is estimated that 9 percent of people who use marijuana will become dependent on it. The number goes up to about 1 in 6 in those who start using young (in their teens) and to 25-50 percent among daily u ...
... Research indicates that students do not remember what they have learned when they are “high”. “It is estimated that 9 percent of people who use marijuana will become dependent on it. The number goes up to about 1 in 6 in those who start using young (in their teens) and to 25-50 percent among daily u ...
A Multifaceted GABAA Receptor Modulator
... general anesthetic etomidate. The negligible activities displayed by methaqualone at numerous neurotransmitter receptors and transporters in an elaborate screening for additional putative central nervous system (CNS) targets suggest that it is a selective GABAAR modulator. The mode of action of meth ...
... general anesthetic etomidate. The negligible activities displayed by methaqualone at numerous neurotransmitter receptors and transporters in an elaborate screening for additional putative central nervous system (CNS) targets suggest that it is a selective GABAAR modulator. The mode of action of meth ...
Has an Angel Shown the Way? Etiological and
... has targeted the redox/GSH site.52 Most compounds studied to date have been compounds-of-convenience, which were able to be studied either because they are natural compounds or fortuitously cross-react with NMDAR as a secondary effect. These compounds have been used almost exclusively as add-on trea ...
... has targeted the redox/GSH site.52 Most compounds studied to date have been compounds-of-convenience, which were able to be studied either because they are natural compounds or fortuitously cross-react with NMDAR as a secondary effect. These compounds have been used almost exclusively as add-on trea ...
Advances in Environmental Biology
... The objective of this research was to experience mental addiction in animals using an experimental model. Thus, Conditioned Place Preference (CPP) method, which is used today as a standard method for assessing drug reward and mental addiction in animals, was selected. This method was used to study e ...
... The objective of this research was to experience mental addiction in animals using an experimental model. Thus, Conditioned Place Preference (CPP) method, which is used today as a standard method for assessing drug reward and mental addiction in animals, was selected. This method was used to study e ...
Metabotropic NMDA receptor function is required for β
... flux through NMDARs (31, 32, 41). To investigate whether ion flux through GluN2B-containing NMDARs is required in Aβmediated synaptic depression, slices were incubated at the time of APP-CT100 viral infection with either 30 μM MK-801 or 200 μM ketamine. Notably, cells expressing APP-CT100 in the prese ...
... flux through NMDARs (31, 32, 41). To investigate whether ion flux through GluN2B-containing NMDARs is required in Aβmediated synaptic depression, slices were incubated at the time of APP-CT100 viral infection with either 30 μM MK-801 or 200 μM ketamine. Notably, cells expressing APP-CT100 in the prese ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.