Methadone Maintenance A Practical Guide to Pharmacotherapy
... Risk Factors for Methadone Toxicity • Use of other central nervous system (CNS) depressants • Lack of tolerance • Respiratory illness • Age • Liver disease • Use of medications which affect methadone metabolism ...
... Risk Factors for Methadone Toxicity • Use of other central nervous system (CNS) depressants • Lack of tolerance • Respiratory illness • Age • Liver disease • Use of medications which affect methadone metabolism ...
Normal Thermoregulatory Responses to 3-iodothyronamine, Trace Amines and Amphetamine-like Psychostimulants in
... Data for the drug effects on thermoregulation were normalized to the saline controls prior to statistical analyses. A twoway ANOVA with repeated measures was employed to determine if there was a significant difference in thermoregulatory responses over all time points between WT and KO mice and acros ...
... Data for the drug effects on thermoregulation were normalized to the saline controls prior to statistical analyses. A twoway ANOVA with repeated measures was employed to determine if there was a significant difference in thermoregulatory responses over all time points between WT and KO mice and acros ...
Nuclear Magnetic Resonance Spectroscopy an Evolutionary
... • Using SAR by NMR, novel lead compounds are constructed that do not exist in corporate libraries and can not be found using conventional methods28. Also this technique avoids the cost and time associated with synthesizing large numbers of complex molecules. • NMR approach in Enhancing High Througho ...
... • Using SAR by NMR, novel lead compounds are constructed that do not exist in corporate libraries and can not be found using conventional methods28. Also this technique avoids the cost and time associated with synthesizing large numbers of complex molecules. • NMR approach in Enhancing High Througho ...
Inhibitors of Factor VIIa/Tissue Factor
... Genomics began with potent FVIIa/TF inhibitors that contained biaryl amidine P1 moieties, such as 5-amidinoindole and 5-amidinobenzimidazole, and replaced these scaffolds with less basic heterocyclic scaffolds that could potentially interact with key residues in the S1 pocket.24,32,33 These inhibito ...
... Genomics began with potent FVIIa/TF inhibitors that contained biaryl amidine P1 moieties, such as 5-amidinoindole and 5-amidinobenzimidazole, and replaced these scaffolds with less basic heterocyclic scaffolds that could potentially interact with key residues in the S1 pocket.24,32,33 These inhibito ...
Structure- Activity Relationships (SAR)
... • The insertion of aromatic system into the structure of the lead will introduce rigidity into the structure as well as increase the size of the analogue. The latter means that small aromatic systems such as benzene and five membered heterocyclic systems are preferred to larger systems. However, the ...
... • The insertion of aromatic system into the structure of the lead will introduce rigidity into the structure as well as increase the size of the analogue. The latter means that small aromatic systems such as benzene and five membered heterocyclic systems are preferred to larger systems. However, the ...
The Diverse Actions of Nicotine and Different
... method employed in this study was modified from the original design by Chow and Cho (1996) and was further discussed in Guo et al. (1999). Rats were exposed to a fixed concentration (4% v/v) of smoke from commercial cigarettes (Kings, UK), with a nicotine content of 1.1 mg/cigarette and a tar conten ...
... method employed in this study was modified from the original design by Chow and Cho (1996) and was further discussed in Guo et al. (1999). Rats were exposed to a fixed concentration (4% v/v) of smoke from commercial cigarettes (Kings, UK), with a nicotine content of 1.1 mg/cigarette and a tar conten ...
A Brief History of Great Discoveries in Pharmacology: In Celebration
... in order not to detract from the concepts and/or ideas that I hoped to convey. The personal anecdotes and vignettes embedded in these essays are meant to express a reverence for the gifted scientists with whom I have had the fortune to interact. But my overall objective relates to the fervent hope t ...
... in order not to detract from the concepts and/or ideas that I hoped to convey. The personal anecdotes and vignettes embedded in these essays are meant to express a reverence for the gifted scientists with whom I have had the fortune to interact. But my overall objective relates to the fervent hope t ...
pharmacological modulation of ureteral peristalsis in a
... reports with an approach similar to that in our physiological study of the UUT. There were several technical problems to overcome. Successful puncture of a minimally dilated UUT of the pig is more difficult than in humans because of the long thoracic cage covering the kidney. Pigs are by nature inte ...
... reports with an approach similar to that in our physiological study of the UUT. There were several technical problems to overcome. Successful puncture of a minimally dilated UUT of the pig is more difficult than in humans because of the long thoracic cage covering the kidney. Pigs are by nature inte ...
Piracetam reverses haloperidol-induced - Tubitak Journals
... by D2 dopamine receptor agonists (36). Catalepsy occurs when more than 80% of D2 receptors are occupied by the drug (37). Catalepsy is also driven by the excitatory adenosine and glutamatergic inputs acting on adenosine A2A and N-methyl-D-aspartate (NMDA) receptors in the striatum. This is because N ...
... by D2 dopamine receptor agonists (36). Catalepsy occurs when more than 80% of D2 receptors are occupied by the drug (37). Catalepsy is also driven by the excitatory adenosine and glutamatergic inputs acting on adenosine A2A and N-methyl-D-aspartate (NMDA) receptors in the striatum. This is because N ...
Role of Mu- and Delta-Opioid Receptors in the
... behavior using MOR- and DOR-selective ligands and endogenous opioid peptides. We found that NAc infusions of MOR and DOR agonists effectively reinstate cocaine seeking through selective actions at their respective receptors. Stimulation of NAc opioid receptors by the endogenous peptides, b-endorphin ...
... behavior using MOR- and DOR-selective ligands and endogenous opioid peptides. We found that NAc infusions of MOR and DOR agonists effectively reinstate cocaine seeking through selective actions at their respective receptors. Stimulation of NAc opioid receptors by the endogenous peptides, b-endorphin ...
Stopping smoking - The Vale Medical Centre
... The above quit smoking programmes have been evaluated in controlled clinical trials in which success rates in smokers using the aid have been compared with similar smokers using a placebo, nothing or something else. There are a number of commercial companies selling materials, devices and treatments ...
... The above quit smoking programmes have been evaluated in controlled clinical trials in which success rates in smokers using the aid have been compared with similar smokers using a placebo, nothing or something else. There are a number of commercial companies selling materials, devices and treatments ...
biochemical pharmacology - WatCut
... This book deals with drugs and their biochemical mechanisms of action. The term “drug” is used here in an inclusive sense, and we will neglect the following possible distinctions: (1) Some drugs are legal, others are not. This difference will not matter for the purpose of this book—we will look at e ...
... This book deals with drugs and their biochemical mechanisms of action. The term “drug” is used here in an inclusive sense, and we will neglect the following possible distinctions: (1) Some drugs are legal, others are not. This difference will not matter for the purpose of this book—we will look at e ...
Receptor af峪ity and potency of non-steroidal antiandrogens
... around two times higher than nilutamide, for wild-type rat,20,27,28 and wild-type human29,30 prostate androgen receptors (Table 1) (reviewed by Furr32). For example, Furr et al reported that in a radioligand displacement study, bicalutamide bound to a wild-type rat prostate androgen receptor prepara ...
... around two times higher than nilutamide, for wild-type rat,20,27,28 and wild-type human29,30 prostate androgen receptors (Table 1) (reviewed by Furr32). For example, Furr et al reported that in a radioligand displacement study, bicalutamide bound to a wild-type rat prostate androgen receptor prepara ...
An Introduction to Medicinal Chemistry
... There can be little doubt that alcohol is a drug and as such causes society more problems than all other drugs put together. One only has to study road accident statistics to appreciate that fact. It has been stated that if alcohol was discovered today, it would be restricted in exactly the same way ...
... There can be little doubt that alcohol is a drug and as such causes society more problems than all other drugs put together. One only has to study road accident statistics to appreciate that fact. It has been stated that if alcohol was discovered today, it would be restricted in exactly the same way ...
Liver X Receptor Agonists as Potential Therapeutic Agents for
... target genes. The nuclear receptors LXR␣ (NR1H3) and LXR (NR1H2) are important regulators of genes involved in lipid metabolism.9 Originally cloned as orphan nuclear receptors,10 it is now believed that both LXR isoforms are intracellular sensors of cholesterol excess.11 Both LXR subtypes are diffe ...
... target genes. The nuclear receptors LXR␣ (NR1H3) and LXR (NR1H2) are important regulators of genes involved in lipid metabolism.9 Originally cloned as orphan nuclear receptors,10 it is now believed that both LXR isoforms are intracellular sensors of cholesterol excess.11 Both LXR subtypes are diffe ...
Effects of psilocybin on hippocampal neurogenesis and extinction of
... James Haley VA Medical Center, Tampa, FL 33613, USA ...
... James Haley VA Medical Center, Tampa, FL 33613, USA ...
Postoperative nausea and vomiting
... ramosetron has a significant effect for preventing PONV compared with placebo, but its efficacy was less than had been reported in previous analyses. They also reported that ramosetron significantly prevented early and late postoperative vomiting compared with ondansetron, but the clinical significa ...
... ramosetron has a significant effect for preventing PONV compared with placebo, but its efficacy was less than had been reported in previous analyses. They also reported that ramosetron significantly prevented early and late postoperative vomiting compared with ondansetron, but the clinical significa ...
Is there a role for EGFR Tyrosine Kinase Inhibitors in recurrent
... Activity with EGFR TKIs has been modest to date in GBM: First generation reversible EGFR inhibitors including gefitinib and erlotinib showed limited activity for several reasons but mainly because these agents were tested in an unselected population. ...
... Activity with EGFR TKIs has been modest to date in GBM: First generation reversible EGFR inhibitors including gefitinib and erlotinib showed limited activity for several reasons but mainly because these agents were tested in an unselected population. ...
Intro to Inhibitors-MM edition-final
... substrates with similar functional groups, side chains, or ...
... substrates with similar functional groups, side chains, or ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.