Metabotropic NMDA receptor function is required for β
... flux through NMDARs (31, 32, 41). To investigate whether ion flux through GluN2B-containing NMDARs is required in Aβmediated synaptic depression, slices were incubated at the time of APP-CT100 viral infection with either 30 μM MK-801 or 200 μM ketamine. Notably, cells expressing APP-CT100 in the prese ...
... flux through NMDARs (31, 32, 41). To investigate whether ion flux through GluN2B-containing NMDARs is required in Aβmediated synaptic depression, slices were incubated at the time of APP-CT100 viral infection with either 30 μM MK-801 or 200 μM ketamine. Notably, cells expressing APP-CT100 in the prese ...
http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf
... trials to criterion by =50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functio ...
... trials to criterion by =50%. Dose-response curves were right-shifted by aging (twice the dose was required to achieve the same enhancement compared with controls). DCS did not affect nonassociative performance but sharpened the conditioned stimulus tone intensity discrimination. DCS thus can functio ...
DAVID E. McCLURE, Ph. D. 10654 Canyon
... Pharmaceutical Consultant with broad experience in all aspects of the development process, including project management, preclinical development, manufacturing of drug substance, formulation development, clinical supplies manufacturing, clinical development and regulatory affairs, as well as discove ...
... Pharmaceutical Consultant with broad experience in all aspects of the development process, including project management, preclinical development, manufacturing of drug substance, formulation development, clinical supplies manufacturing, clinical development and regulatory affairs, as well as discove ...
Nicotine Self-Administration in Animals: A Reevaluation
... findings, that ‘‘sucrose þ nicotine solutions are more reinforcing than sucrose solutions alone (p. 341).’’ In making this unequivocal statement, which appears in the abstract of the article, Smith and Roberts apparently did not consider the alternative explanations discussed above. Specifically, th ...
... findings, that ‘‘sucrose þ nicotine solutions are more reinforcing than sucrose solutions alone (p. 341).’’ In making this unequivocal statement, which appears in the abstract of the article, Smith and Roberts apparently did not consider the alternative explanations discussed above. Specifically, th ...
Modification of Practice-dependent Plasticity in Human Motor Cortex
... be studied non-invasively by various transcranial magnetic stimulation (TMS) protocols (Classen and Cohen, 2003). One particularly well-established protocol included subjects in whom it was possible to induce with focal TMS of one motor cortex isolated thumb movements of the contralateral hand point ...
... be studied non-invasively by various transcranial magnetic stimulation (TMS) protocols (Classen and Cohen, 2003). One particularly well-established protocol included subjects in whom it was possible to induce with focal TMS of one motor cortex isolated thumb movements of the contralateral hand point ...
The Role of Ligand Efficiency Measures in Drug Discovery
... whereas a drug candidate with LLE = 6 has a one million-fold preference for its target versus 1-octanol. Negative LLE values are clearly unfavourable. Based on the properties of an average oral drug, with cLogP ~2.5-3.0 and potency in the range ~1–10 nM, an ideal LLE value for an optimised candidate ...
... whereas a drug candidate with LLE = 6 has a one million-fold preference for its target versus 1-octanol. Negative LLE values are clearly unfavourable. Based on the properties of an average oral drug, with cLogP ~2.5-3.0 and potency in the range ~1–10 nM, an ideal LLE value for an optimised candidate ...
Blum et al. 2011 - Boston University
... inability to cope with stress [30]. Thus, genetic hypodopaminergic activity of the brain predisposes an individual to seek substances and/or behaviors that will overcome this anhedonic state by activating mesolimbic dopaminergic centers [31]. It turns out that these substances and behaviors include ...
... inability to cope with stress [30]. Thus, genetic hypodopaminergic activity of the brain predisposes an individual to seek substances and/or behaviors that will overcome this anhedonic state by activating mesolimbic dopaminergic centers [31]. It turns out that these substances and behaviors include ...
... This study demonstrates that the TP receptor antagonist, BAY u 3405, produces only partial protection against PGD2-induced airway narrowing at 90 min after ingestion. The magnitude of protection was similar when 20, 50 or 100 mg doses were used, despite increasing plasma concentrations of BAY u 3405 ...
Consideration of Sex in Clinical Trials of Transdermal Nicotine Patch
... treatment outcomes by sex. Fifteen studies found no association of sex with smoking cessation outcomes and seven studies found better TNP outcomes for men (see Table 1). One additional study reported outcomes of carbon monoxide (CO) levels by sex (Levin et al., 1994; see Table 1). Among the 21 studi ...
... treatment outcomes by sex. Fifteen studies found no association of sex with smoking cessation outcomes and seven studies found better TNP outcomes for men (see Table 1). One additional study reported outcomes of carbon monoxide (CO) levels by sex (Levin et al., 1994; see Table 1). Among the 21 studi ...
Testing and Comparison of Non-Opioid Analgesics in Amphibians
... phenothiazine agent, chlorpromazine, has mixed antagonist activities at dopamine, cholinergic, and adrenergic receptors, whereas the newer agent, haloperidol, is more selective for dopamine receptors. The fact that both agents induced an elevation of the nociceptive threshold suggests that dopaminer ...
... phenothiazine agent, chlorpromazine, has mixed antagonist activities at dopamine, cholinergic, and adrenergic receptors, whereas the newer agent, haloperidol, is more selective for dopamine receptors. The fact that both agents induced an elevation of the nociceptive threshold suggests that dopaminer ...
neuro 2007 - addiction education home
... Chronic cocaine and heroin users display a variety of central nervous system (CNS) dysfunctions including impaired attention, learning, memory, reaction time, cognitive flexibility, impulse control and selective processing. These findings suggest that these drugs may alter normal brain functions and ...
... Chronic cocaine and heroin users display a variety of central nervous system (CNS) dysfunctions including impaired attention, learning, memory, reaction time, cognitive flexibility, impulse control and selective processing. These findings suggest that these drugs may alter normal brain functions and ...
Drugs for Bacterial Infections
... the balance between dopamine and acetylcholine in the brain. Dopamine releaser (Antiviral): Medications: Amantadine (Symmetrel) Actions: Antiviral stimulate DA release, prevent dopamine reuptake, and may block cholinergic and glutamate receptors Therapeutic Uses: - These medications do not halt the ...
... the balance between dopamine and acetylcholine in the brain. Dopamine releaser (Antiviral): Medications: Amantadine (Symmetrel) Actions: Antiviral stimulate DA release, prevent dopamine reuptake, and may block cholinergic and glutamate receptors Therapeutic Uses: - These medications do not halt the ...
- Acta Medica Iranica
... receptor complex (21-22). On the other hand, Dcycloserine, a partial agonist with ≈60% activity at the glycine site of the NMDA receptor, which readily facilitates learning in animals, has produced promising results (21). The involvement of glutamatergic system in schizophrenia may have important im ...
... receptor complex (21-22). On the other hand, Dcycloserine, a partial agonist with ≈60% activity at the glycine site of the NMDA receptor, which readily facilitates learning in animals, has produced promising results (21). The involvement of glutamatergic system in schizophrenia may have important im ...
The Glutamatergic System and Alzheimer`s Disease
... correlates with both their cognitive and functional status.[62] Two other in vivo reports of GLX in Alzheimer’s disease revealed no significant difference in the mid-frontal or temporoparietal GLX[63] but an increase in GLX in the occipital lobe[64] of patients with Alzheimer’s disease. One enzyme t ...
... correlates with both their cognitive and functional status.[62] Two other in vivo reports of GLX in Alzheimer’s disease revealed no significant difference in the mid-frontal or temporoparietal GLX[63] but an increase in GLX in the occipital lobe[64] of patients with Alzheimer’s disease. One enzyme t ...
5-Hydroxytryptamine2C Receptor Contribution to m
... Animal Surgery and Preparation. All procedures were approved by the Vanderbilt University Medical Center Institutional Animal Care and Use Committees and were conducted according to the NIH Guide for the Care and Use of Laboratory Animals. Adult male Sprague-Dawley rats (n ⫽ 6 per group) were housed ...
... Animal Surgery and Preparation. All procedures were approved by the Vanderbilt University Medical Center Institutional Animal Care and Use Committees and were conducted according to the NIH Guide for the Care and Use of Laboratory Animals. Adult male Sprague-Dawley rats (n ⫽ 6 per group) were housed ...
6 points each
... 9. Dry mouth is a major side effect of olanzapine in many patients. Orthostatic hypotension is also seen in some patients. Theoretically, what kinds of change(s) in receptor binding would be desirable in a new drug (call it “neo-olanzapine”) that would have the same therapeutic effect and potency as ...
... 9. Dry mouth is a major side effect of olanzapine in many patients. Orthostatic hypotension is also seen in some patients. Theoretically, what kinds of change(s) in receptor binding would be desirable in a new drug (call it “neo-olanzapine”) that would have the same therapeutic effect and potency as ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.