Hallucinogens - Multidisciplinary Association for Psychedelic Studies
... for this drug class. The famous German toxicologist Louis Lewin used the name phantastica earlier in this century (Lewin, 1964), and as we shall see later, such a descriptor is not so farfetched. The most popular names, hallucinogen, psychotomimetic, and psychedelic (‘‘mind manifesting’’; Osmond, 19 ...
... for this drug class. The famous German toxicologist Louis Lewin used the name phantastica earlier in this century (Lewin, 1964), and as we shall see later, such a descriptor is not so farfetched. The most popular names, hallucinogen, psychotomimetic, and psychedelic (‘‘mind manifesting’’; Osmond, 19 ...
Molecular Basis of Multidrug Transport by ATP
... the ester moieties are rapidly cleaved by intracellular esterases and the resulting carboxylates are not substrates for P-glycoprotein and LmrA (Homolya et al., 1993; Bolhuis et al., 1996a), and (iii) the kinetics of ATP-dependent transport of Hoechst 33342 by P-glycoprotein in insideout membrane ve ...
... the ester moieties are rapidly cleaved by intracellular esterases and the resulting carboxylates are not substrates for P-glycoprotein and LmrA (Homolya et al., 1993; Bolhuis et al., 1996a), and (iii) the kinetics of ATP-dependent transport of Hoechst 33342 by P-glycoprotein in insideout membrane ve ...
An Introduction to Medicinal Chemistry
... mechanisms which the medicinal chemist can target to get the desired results, and so to expect all painkillers to look alike or to have some common thread running through them is not realistic. A further point is that many drugs do not fit purely into one category or another and some drugs may have ...
... mechanisms which the medicinal chemist can target to get the desired results, and so to expect all painkillers to look alike or to have some common thread running through them is not realistic. A further point is that many drugs do not fit purely into one category or another and some drugs may have ...
Rib_Inh_15
... ribosomal RNA and freeze the 30S initiation complex (30S-mRNAtRNA) so that no further initiation can occur. They also slow down protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r-RNA the aminoglycosides increase the affinity of the A site for t-R ...
... ribosomal RNA and freeze the 30S initiation complex (30S-mRNAtRNA) so that no further initiation can occur. They also slow down protein synthesis that has already initiated and induce misreading of the mRNA. By binding to the 16 S r-RNA the aminoglycosides increase the affinity of the A site for t-R ...
Novel Therapy for Nicotine Addiction in Alcohol Dependent Rats
... study of people who smoked and were simultaneously in some form of other drug abuse treatment, 74% judged the difficulty of quitting smoking to be at the same level if not more difficult than stopping their drug of treatment focus. In the same study, one in three individuals considered it “much hard ...
... study of people who smoked and were simultaneously in some form of other drug abuse treatment, 74% judged the difficulty of quitting smoking to be at the same level if not more difficult than stopping their drug of treatment focus. In the same study, one in three individuals considered it “much hard ...
Butorphanol-Mediated Antinociception in Mice: Partial Agonist
... are mediated by mu receptors, a finding supported by its sensitivity to the antagonist effects of the competitive antagonist quadazocine and by an apparent pA2 value that has been associated with activity at mu receptors (Butelman et al., 1995). Conversely, in squirrel monkeys, butorphanol attenuate ...
... are mediated by mu receptors, a finding supported by its sensitivity to the antagonist effects of the competitive antagonist quadazocine and by an apparent pA2 value that has been associated with activity at mu receptors (Butelman et al., 1995). Conversely, in squirrel monkeys, butorphanol attenuate ...
Review Drug chirality: a consideration of the significance
... A survey of 1675 drugs carried out in the early 1980s, indicated that 1200 (71.6%) could be classified as synthetic and 475 (28.4%) as natural products or semisynthetic agents. Four hundred and eighty (28.7%) of the synthetic compounds were chiral and of these 58 (3.5%) were marketed as single isome ...
... A survey of 1675 drugs carried out in the early 1980s, indicated that 1200 (71.6%) could be classified as synthetic and 475 (28.4%) as natural products or semisynthetic agents. Four hundred and eighty (28.7%) of the synthetic compounds were chiral and of these 58 (3.5%) were marketed as single isome ...
Inhibition of platelet aggregability by losartan in essential hypertension
... Platelet responsiveness to the thrombin receptoractivating peptide SFLRRN-NH2 (PMIS387, Bachem, California) was determined from platelet-rich plasma prepared by centrifugation of the blood at 900 rpm for 15 minutes at 20° C, as described elsewhere11, Platelet aggregations were performed from platele ...
... Platelet responsiveness to the thrombin receptoractivating peptide SFLRRN-NH2 (PMIS387, Bachem, California) was determined from platelet-rich plasma prepared by centrifugation of the blood at 900 rpm for 15 minutes at 20° C, as described elsewhere11, Platelet aggregations were performed from platele ...
Med-Psych Drug-Drug Interactions Update Triptans
... et al., no significant clinical events occurred, and the authors suggested that no dose adjustment was necessary. These modest findings reflect almotriptan’s multiple avenues of metabolism, which allow the drug to be biotransformed despite “roadblocks” at some of its metabolic sites. We could not fi ...
... et al., no significant clinical events occurred, and the authors suggested that no dose adjustment was necessary. These modest findings reflect almotriptan’s multiple avenues of metabolism, which allow the drug to be biotransformed despite “roadblocks” at some of its metabolic sites. We could not fi ...
Open PDF File - Array BioPharma
... incubator at 37°C for 2 minutes. The plates were spun in a centrifuge for 10 minutes at 750 x g. Supernant was diluted 2:1 with acetonitrile spiked with labetalol (0.4 µM final concentration), as the internal standard. Samples were quantified via LC-MS/MS (API4000) and Kd values were calculated. ...
... incubator at 37°C for 2 minutes. The plates were spun in a centrifuge for 10 minutes at 750 x g. Supernant was diluted 2:1 with acetonitrile spiked with labetalol (0.4 µM final concentration), as the internal standard. Samples were quantified via LC-MS/MS (API4000) and Kd values were calculated. ...
Nicotinic agonist
A nicotinic agonist is a drug that mimics the action of acetylcholine (ACh) at nicotinic acetylcholine receptors (nAChRs). The nAChR is named for its affinity for nicotine.Examples include nicotine (by definition), acetylcholine (the endogenous agonist of nAChRs), choline, epibatidine, lobeline, varenicline and cytisine.