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5.1 Energy Systems  - Blyth-Exercise
5.1 Energy Systems - Blyth-Exercise

... ETC – the finer details • When oxygen is reduced, it also bonds with 2 H+, and forms one H2O (inside the matrix) • Oxygen is the final electron acceptor (This is why we need oxygen to live!) ...
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... burden, in addition to the 2 people who are waiting for you at the door from the gumball machine. You need to take all of them to the Electron Transport Chain so someone else can lift their burden and they can get back to work at the gumball machine again. Electron Transport System /Oxidatibe Phosph ...
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CHAPTER-III CARBOHYDRATE METABOLISM

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... Bind to another part of an enzyme, changing the function A noncompetitive inhibitor binds to the enzyme away from the active site, altering the conformation of the enzyme so that its ...
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... Example: Glucose phosphorylation to glucose-6-phosphate Muscle and brain: hexokinase Km = 20-120uM. Phosphorylates glucose even when blood glucose is low. Important in brain which relies solely on glucose Liver: glucokinase Km=5mM. Responds when blood glucose elevated (i.e. after meal) to minimise h ...
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Surface Infrared Spectroscopic Study of ATP Synthesis in Mitochondria

... Therefore, there is a great demand for non-destructive monitoring for ATP synthesis in mitochondria and its application to drug screening for mitochondrial toxicants. In the present study, we have monitored ATP synthesis in isolated mitochondria by using IRAS in the multiple internal reflection (MIR ...
video slide - Ethical Culture Fieldston School
video slide - Ethical Culture Fieldston School

... – Is an energy-coupling mechanism that uses energy in the form of a H+ gradient across a membrane to drive cellular work ...
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Oxidative phosphorylation



Oxidative phosphorylation (or OXPHOS in short) is the metabolic pathway in which the mitochondria in cells use their structure, enzymes, and energy released by the oxidation of nutrients to reform ATP. Although the many forms of life on earth use a range of different nutrients, ATP is the molecule that supplies energy to metabolism. Almost all aerobic organisms carry out oxidative phosphorylation. This pathway is probably so pervasive because it is a highly efficient way of releasing energy, compared to alternative fermentation processes such as anaerobic glycolysis.During oxidative phosphorylation, electrons are transferred from electron donors to electron acceptors such as oxygen, in redox reactions. These redox reactions release energy, which is used to form ATP. In eukaryotes, these redox reactions are carried out by a series of protein complexes within the inner membrane of the cell's mitochondria, whereas, in prokaryotes, these proteins are located in the cells' intermembrane space. These linked sets of proteins are called electron transport chains. In eukaryotes, five main protein complexes are involved, whereas in prokaryotes many different enzymes are present, using a variety of electron donors and acceptors.The energy released by electrons flowing through this electron transport chain is used to transport protons across the inner mitochondrial membrane, in a process called electron transport. This generates potential energy in the form of a pH gradient and an electrical potential across this membrane. This store of energy is tapped by allowing protons to flow back across the membrane and down this gradient, through a large enzyme called ATP synthase; this process is known as chemiosmosis. This enzyme uses this energy to generate ATP from adenosine diphosphate (ADP), in a phosphorylation reaction. This reaction is driven by the proton flow, which forces the rotation of a part of the enzyme; the ATP synthase is a rotary mechanical motor.Although oxidative phosphorylation is a vital part of metabolism, it produces reactive oxygen species such as superoxide and hydrogen peroxide, which lead to propagation of free radicals, damaging cells and contributing to disease and, possibly, aging (senescence). The enzymes carrying out this metabolic pathway are also the target of many drugs and poisons that inhibit their activities.
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