General theory of enzyme action, by Leonor Michaelis and Maud
... nucleotide base synthesis. It is used to treat cancer. ...
... nucleotide base synthesis. It is used to treat cancer. ...
Structure, function, and evolution of phosphoglycerate mutases
... residues, His8 and His181, with the His8 involved in forming a phosphohistidine±enzyme intermediate as a part of the catalytic cycle of this dPGM enzyme (Fig 2(b)) (Winn et al., 1981; Fothergill-Gilmore and Watson, 1989; Rose 1971, 1980; Nairn et al., 1995). The precise determination of all residues ...
... residues, His8 and His181, with the His8 involved in forming a phosphohistidine±enzyme intermediate as a part of the catalytic cycle of this dPGM enzyme (Fig 2(b)) (Winn et al., 1981; Fothergill-Gilmore and Watson, 1989; Rose 1971, 1980; Nairn et al., 1995). The precise determination of all residues ...
Biochemistry of saliva and tooth tissues
... -1,4-glycosidic bonds in the starch activated by chloride ions the optimum pH for its action: 6-7 is helpful in removing the carbohydrate fibers located between teeth It is responsible for the formation of a glycoprotein complex of pellicle. This complex is formed directly on the washed teeth. On th ...
... -1,4-glycosidic bonds in the starch activated by chloride ions the optimum pH for its action: 6-7 is helpful in removing the carbohydrate fibers located between teeth It is responsible for the formation of a glycoprotein complex of pellicle. This complex is formed directly on the washed teeth. On th ...
Biochemistry
... Bis is of two parts; Bi =ثنائي, while s = “separated” (i.e. on different locations) Glycerald. 3-P converts into 2,3 bis PG or 2,3 BPG or 1,3 DPG and is present in most cells at low concentrations, but in the RBCs (erythrocytes) it is at high concentration (4 mM) which is equal to hemoglobin. I ...
... Bis is of two parts; Bi =ثنائي, while s = “separated” (i.e. on different locations) Glycerald. 3-P converts into 2,3 bis PG or 2,3 BPG or 1,3 DPG and is present in most cells at low concentrations, but in the RBCs (erythrocytes) it is at high concentration (4 mM) which is equal to hemoglobin. I ...
Impact of glucose uptake rate on recombinant protein production in
... Today, it is a common strategy for production of many high-value proteins used in for example various medical applications (e.g., vaccines, recombinant factor VIII for treatment of haemophilia, insulin for treatment of diabetes and tissue-plasminogen activator against stroke). The principle behind t ...
... Today, it is a common strategy for production of many high-value proteins used in for example various medical applications (e.g., vaccines, recombinant factor VIII for treatment of haemophilia, insulin for treatment of diabetes and tissue-plasminogen activator against stroke). The principle behind t ...
INSULIN
... spurts of insulin release. This oscillation is important to consider when administering insulin-stimulating medication as oscillation is the target & not a constant high concentration. ...
... spurts of insulin release. This oscillation is important to consider when administering insulin-stimulating medication as oscillation is the target & not a constant high concentration. ...
PPT - Portland State University
... that the subtle change in bond configuration from 22:6n-3 to 22:5n-6 produces more structured acyl chain packing in the bilayer midplane, leading to delayed and reduced MII–Gt interaction and PDE function. ...
... that the subtle change in bond configuration from 22:6n-3 to 22:5n-6 produces more structured acyl chain packing in the bilayer midplane, leading to delayed and reduced MII–Gt interaction and PDE function. ...
Effects of signaling on subcellular localization of MITF
... MAPK boðferilsins í að minnsta kosti 90% sortuæxla. Fosfórýlerun umritunarþátta getur haft áhrif á virkni þeirra, stöðugleika, prótein samskipti og innanfrumu staðsetningu þeirra. Ekki er mikið vitað um áhrif fosfórýlerunar á MITF en það er að jafnaði samþykkt að þegar serín set 73 og 409 eru fosfór ...
... MAPK boðferilsins í að minnsta kosti 90% sortuæxla. Fosfórýlerun umritunarþátta getur haft áhrif á virkni þeirra, stöðugleika, prótein samskipti og innanfrumu staðsetningu þeirra. Ekki er mikið vitað um áhrif fosfórýlerunar á MITF en það er að jafnaði samþykkt að þegar serín set 73 og 409 eru fosfór ...
Lysosomal Enzymes Are Released From Cultured Human
... the mainly intracellular staining of LAMP-1 (panel H), cathepsin D and LAL were widely present extracellularly in the intima. Next, we studied whether lysosomal hydrolases released from human monocyte-derived macrophages could modify LDL in vitro. As a model of stimulation-induced secretion of acid ...
... the mainly intracellular staining of LAMP-1 (panel H), cathepsin D and LAL were widely present extracellularly in the intima. Next, we studied whether lysosomal hydrolases released from human monocyte-derived macrophages could modify LDL in vitro. As a model of stimulation-induced secretion of acid ...
Fatty acids - Haverford Alchemy
... 3. What are the major pathways in the metabolism of triacylglycerols? Be able to name the major pathways for the synthesis and breakdown of triacylglycerols and fatty acids, and identify their connections to other metabolic pathways. 4. How are triacylglycerols moved into and out of storage in adipo ...
... 3. What are the major pathways in the metabolism of triacylglycerols? Be able to name the major pathways for the synthesis and breakdown of triacylglycerols and fatty acids, and identify their connections to other metabolic pathways. 4. How are triacylglycerols moved into and out of storage in adipo ...
Chapter 10 Enzymes - Angelo State University
... Mg2+, Zn2+, or Fe2+). • The protein portion is called an apoenzyme: ...
... Mg2+, Zn2+, or Fe2+). • The protein portion is called an apoenzyme: ...
File Ref.No.7054/GA - IV - J1/2013/CU UNIVERSITY OF CALICUT
... The Modified Regulations of Choice Based Credit Semester System for UG Curriculum w.e.f 2014 was implemented under the University of Calicut vide paper read as (1). The Revised CUCBCSS UG Regulations has been implemented w.e.f 2014 admission, for all UG programmes under CUCBCSS in the University, vi ...
... The Modified Regulations of Choice Based Credit Semester System for UG Curriculum w.e.f 2014 was implemented under the University of Calicut vide paper read as (1). The Revised CUCBCSS UG Regulations has been implemented w.e.f 2014 admission, for all UG programmes under CUCBCSS in the University, vi ...
Metabolic fate and effects of saturated and unsaturated fatty acids in
... Previous studies have reported the presence of carnitine palmitoyltransferase 1 and II in tumor cells and the inhibitory effects of fatty acids on cell proliferation. The present work considered the metabolic fate of [14C] or [3HI-labeled fatty acids and their effects on cellular metabolism in Hep2 ...
... Previous studies have reported the presence of carnitine palmitoyltransferase 1 and II in tumor cells and the inhibitory effects of fatty acids on cell proliferation. The present work considered the metabolic fate of [14C] or [3HI-labeled fatty acids and their effects on cellular metabolism in Hep2 ...
Ch 6 LIPID METABOLISM - FORMATTED - NSDL
... from 1% (in chylomicron) to 70% (in HDL). There are several types of apoproteins viz ApoA, -B, -C, -D and -E, which, in turn, have many sub-types. They are differentiated on the basis of their size, antigenic properties, and distribution. Apoproteins not only make lipid transport possible in plasma ...
... from 1% (in chylomicron) to 70% (in HDL). There are several types of apoproteins viz ApoA, -B, -C, -D and -E, which, in turn, have many sub-types. They are differentiated on the basis of their size, antigenic properties, and distribution. Apoproteins not only make lipid transport possible in plasma ...
regulation of fatty acid synthesis
... signals to cross organellar boundaries. Because fatty acids are produced in the plastid, but are principally esterified outside this organelle, a system for communicating between the source and the sinks for fatty acid utilization is essential. The nature of this communication and the signal molecul ...
... signals to cross organellar boundaries. Because fatty acids are produced in the plastid, but are principally esterified outside this organelle, a system for communicating between the source and the sinks for fatty acid utilization is essential. The nature of this communication and the signal molecul ...
Smooth Muscle - Collin College
... In addition, there are so many other molecules with which it can interact, that it is quickly consumed close to where it is synthesized. It thus has a very short live span. • Thus NO acts in a paracrine or even autocrine fashion — affecting only cells near its point of synthesis or effecting the ce ...
... In addition, there are so many other molecules with which it can interact, that it is quickly consumed close to where it is synthesized. It thus has a very short live span. • Thus NO acts in a paracrine or even autocrine fashion — affecting only cells near its point of synthesis or effecting the ce ...
UvA-DARE (Digital Academic Repository)
... Abstract: Modifying substrate uptake systems is a potentially powerful tool in metabolic engineering. This research investigates energetic and metabolic changes brought about by the genetic modification of the glucose uptake and phosphorylation system of Escherichia coli. The engineered strain PPA31 ...
... Abstract: Modifying substrate uptake systems is a potentially powerful tool in metabolic engineering. This research investigates energetic and metabolic changes brought about by the genetic modification of the glucose uptake and phosphorylation system of Escherichia coli. The engineered strain PPA31 ...
Mitochondrial Membrane Potential in Cardiac
... oxygen and it could be argued that mitochondrial requirement for oxygen delivery has driven the evolution of the respiratory and cardiovascular system. Mitochondria are primarily ATP generators. This is far from trivial: ATP is the major currency in the energy economy in all living things, from bact ...
... oxygen and it could be argued that mitochondrial requirement for oxygen delivery has driven the evolution of the respiratory and cardiovascular system. Mitochondria are primarily ATP generators. This is far from trivial: ATP is the major currency in the energy economy in all living things, from bact ...
Dr. Murad`s Abstract
... biological processes. Nitric oxide is formed from L-arginine by a family of enzymes called nitric oxide synthases. These enzymes have a complex requirement for a number of co-factors and regulators including NADPH, tetrahydrobioterin, flavins, calmodulin and heme. The enzymes are present in most cel ...
... biological processes. Nitric oxide is formed from L-arginine by a family of enzymes called nitric oxide synthases. These enzymes have a complex requirement for a number of co-factors and regulators including NADPH, tetrahydrobioterin, flavins, calmodulin and heme. The enzymes are present in most cel ...
Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase and
... that accumulate ceramide to gain insight into metabolic pathways that could be altered in these mutants. Our earlier study combined metabolomic profiling with genetic and biochemical approaches and demonstrated that dcerk1 mutants show an increased reliance on glycolysis, which leads to an increase ...
... that accumulate ceramide to gain insight into metabolic pathways that could be altered in these mutants. Our earlier study combined metabolomic profiling with genetic and biochemical approaches and demonstrated that dcerk1 mutants show an increased reliance on glycolysis, which leads to an increase ...
Slide 1
... - relieves inhibition by ATP Citrate - feedback inhibitor - regulates supply of pyruvate - links Glycolysis and CAC Fru-2,6-bisphosphate - strong activator - produced by PFK-2 when excess fru-6-phosphate - indirect means of substrate stimulation or feed forward activation ...
... - relieves inhibition by ATP Citrate - feedback inhibitor - regulates supply of pyruvate - links Glycolysis and CAC Fru-2,6-bisphosphate - strong activator - produced by PFK-2 when excess fru-6-phosphate - indirect means of substrate stimulation or feed forward activation ...
Plant purple acid phosphatases — genes, structures and biological
... however, for proteins secreted outside the cell and induced by low phosphate level, the sugar content may be significantly higher (Miller et al., 2001). Most known PAPs are secreted, soluble proteins, except for glycosyl-phoshatidylinositol-anchored phosphatase isolated from Spirodela oligorhhiza ce ...
... however, for proteins secreted outside the cell and induced by low phosphate level, the sugar content may be significantly higher (Miller et al., 2001). Most known PAPs are secreted, soluble proteins, except for glycosyl-phoshatidylinositol-anchored phosphatase isolated from Spirodela oligorhhiza ce ...
SharifMZ_0808_eps - Heriot
... trying to improve the yield and productivity of amino acids by developing genetically modified organisms or through the use of metabolic engineering tools. In this study, a new approach by which the utilization of transient electropermeabilization for increasing the membrane permeability of these ba ...
... trying to improve the yield and productivity of amino acids by developing genetically modified organisms or through the use of metabolic engineering tools. In this study, a new approach by which the utilization of transient electropermeabilization for increasing the membrane permeability of these ba ...
Inhibition of 17beta-hydroxysteroid dehydrogenases by
... position 7. For flavonoids the issue is more complex due to the presence or absence of a double bond in ring C, the position of ring B as well as the hydroxylation pattern. Under reductive conditions a double bond in ring C increases the inhibitory potency (e.g. naringenin versus apigenin). In contr ...
... position 7. For flavonoids the issue is more complex due to the presence or absence of a double bond in ring C, the position of ring B as well as the hydroxylation pattern. Under reductive conditions a double bond in ring C increases the inhibitory potency (e.g. naringenin versus apigenin). In contr ...
Lipid signaling
Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. Lipid signaling is thought to be qualitatively different from other classical signaling paradigms (such as monoamine neurotransmission) because lipids can freely diffuse through membranes (see osmosis.) One consequence of this is that lipid messengers cannot be stored in vesicles prior to release and so are often biosynthesized ""on demand"" at their intended site of action. As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum.