Download 1 Table S1. Pathway/Function Gene Symbol Fold Change Function

1
Table S1.
Pathway/Function
Gene
Symbol
Fold Change
Function
Cytokines and
Chemokines
Chemokine(C-C)
motif ligand 8
Ccl8
1.2↑
Chemotactic for and activates
monocytes, T cells and mast
cells that are involved in
inflammatory response
Chemokine(C-C)
motif ligand 22
Ccl22
1.08↑
M2 macrophage marker.
Specifically attracts monocyte
and regulate macrophage
function.
Chemokine(C-C)
motif ligand 2
Ccl2
1.15↑
M2 macrophage marker.
Recruits monocyte, memory
T cells and dendritic cells to
sites of infection and
inflammation
Chemokine(C-C)
motif ligand 7
Ccl7
1.19↑
Specifically attracts
monocytes and regulate
macrophage function
Chemokine(C-C)
motif ligand 12
Ccl12
1.2↑
Specifically attracts
monocytes, eosinophills and
lymphocytes
Interferon alpha
inducible protein 27
like 1
Ifi27l1
0.86↓
Promotes cell death.
Mediates IFN-induced
apoptosis characterized by a
rapid and robust release of
cytochrome C from the
mitochondria and activation of
BAX and caspases 2, 3, 6, 8
and 9
Tumor Necrosis
Factor alpha induced
protein 8
Tnfaip8
0.96↓
Suppressor of TNF alpha
induced apoptosis
Kinase insert domain
repeat
Kdr
1.13↑
Main mediator for VEGFinduced endothelial
proliferation, survival,
VEGF signaling
Pathway
2
migration, tubular
morphogenesis and
sprouting.
Invasion and
Angiogeneis
FMS-related tyrosine
Kinase 1
Flt1,
VEGFR1
Matrix
metallopeptidase 9
MMP9
Matrix
metallopeptidase 25
1.15↑
1.19↑
Breakdown of extracellular
matrix proteins, tumor
associated tissue remodeling,
role in tumor growth and
metastasis
MMP25
1.1↑
Tumor invasion and
metastasis through activation
of MMP2
Matrix
metallopeptidase 13
MMP13
1.13↑
Cell migration, angiogenesis,
tumor growth and host
defence
Cyclin D1
Ccnd 1
Cell Cycle
1.14↑
Cyclin D2
Ccnd 2
0.97↑
Membrane
Receptors
Angiogenesis, patterning of
blood vessels, cell adhesion,
cell differentiation, cell
migration.
Membrane-spanning4- domains Subfamily
A, member 4D
Ms4a4d
1.18↑
Macrophage adhesion,
motility and migration
Mediator of cell division,
Macrophage activation by
LPS
This gene encodes a Blymphocyte surface molecule
which plays a role in the
development and
differentiation of B-cells into
plasma cells.
unknown
Membrane spanning
4 domains Subfamily
A, member 4C
Ms4a4c
1.08↑
3
G protein-coupled
receptor 31
Gpr31c
1.13↑
Shows high affinity for the
lipid mediator 12lipoxygenase-derived
product 12-(S)-hydroxy5,8,10,14-eicosatetraenoic
acid (HETE
Member of adhesion
GPCR family of receptors
1.25↑
G protein-coupled
receptor 128
Histamine Receptor
H2
Aryl -hydrocarbon
Receptor
Insulin Receptor
Gpr128
1.04↑
Inflammatory role in
macropahges.
Hrh2
0.86↓
Ahr
ligand-activated
transcription factor
involved in
immunoregulatory role in
macrophages and T cells
involved in expression of
eNOS in endothelial cells
Insr
0.93↓
Chemokine (C-C)
motif receptor 1 like 1
1.15↑
Ccr1l1
involved in C-C chemokine
activity and G-protein
coupled receptor activity
4
Chemokine (C motif)
receptor 1
also known as GPR5.
involved in inflammatory
response.
Xcr1
0.89↓
unknown
Transmembrane
protein 209
Tmem209
1.08↑
unknown
RELT like 1
Rell1
1.04↑
unknown
Macrophage
activation 2 like
Mpa2l
1.18↑
Involved in macrophage
activation and differentiation
Schlafen4
Slfn4
1.47↑
unknown
Schlafen9
Slfn9
1.15↑
Slfn1
1.29↑
Schlafen1
Promotes cell growth and
development of T
lymphocytes
Involved in nucleotide
metabolism pathway
Enzymes
Uridine-cytidine
kinase2
Uck2
0.79↓
Lactate
dehydrogenase B
Ldhb
0.84↓
Converts pyruvate final
product of glycolysis to
lactate
5
Phosphoglycerate
kinase1
Pgk1
0.96↓
Major enzyme used in
glycolysis in the first ATP
generating step of glycolytic
pathway.
0.88↓
Enzyme of glycolysis and
converts fructose1, 6
bisphosphate into
glyceraldehydes 3 phosphate
and dihydroxyacetone
phosphate.
Aldolase C
Aldoc
Play important role in cell
proliferation and survival
Ceramide kianse like
Cerkl
Adenylate kinase 3
like 1
Ak3l1
1.08↑
0.84↓
Involved in nucleotide
metabolism pathway and
catalyzes the interconversion
of adenine nucleotides
0.92↓
Enzyme of glycolysis,
phosphorylates fructose-6phosphate
Phosphofructokinase1
Pfk1
Inosine
monophosphate
dehydrogenase
Apoptosis related
protein
BCL2 adenovirus E1B
interacting protein 3
Impdh1
0.95↓
Enzyme involved in
nucleotide metabolism
converts inosine
monophosphate to xanthine
monophosphate
Known to induce apoptosis
Bnip3
0.92↓
Involved in homeostasis of
endogenous nucleosides
Solute Carrier
Solute Carrier family
protein family 28,
member 2
Slc28a2
1.16↑
6
Mediates transport of sodium
and bicarbonate ions
Solute Carrier family
protein family 4,
member 7
Solute Carrier family
protein family 25,
member 23
Slc4a7
0.866↓
Gene functions as a gated
pore that translocates ADP
from mitochondrial matrix to
cytoplasm
Slc25a23
0.877↓
Important transporter of
glutamine an intermediate in
the detoxification of ammonia
Solute Carrier family
protein family 38,
member1
Solute Carrier family
protein family 44,
member 23
Slc38a1
Slc44a1
0.97↓
0.95↓
Amino acid transporters play
essential role in uptake of
nutrients, production of
energy
Participates in degradation of
VLDL
Extracellular
mediators
Sortilin1
Sort1
0.80↓
Fibrinogen like 2
Fgl2
Insulin like growth
factor binding protein4
1.13↑
Found on surface of
macrophages and involved in
immune and adaptive
response
Serve as carrier protein for
IGF1
Igfbp4
0.92↓
Attach hydroxyl group to
lysine in collagen like proteins
Procollagen lysine
hydroxylase
Plod1
1.07↑