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Defining the role of Histidyl tRNA Synthetase in the Zebrafish Eye and Ear Aminoacyl tRNA synthetases are critical enzymes responsible for attaching specific amino acids to their appropriate tRNA molecules during protein synthesis. In humans, a point mutation in the gene for Histidine tRNA Synthetase (HARS) has been associated with Usher Syndrome Type 3b, a disease characterized by hearing and vision loss by early adulthood. This association suggests an important role for HARS in eye and ear development and maintenance. The use of antisense morpholinos to knockdown HARS expression in zebrafish results in a lack of retinal organization and loss of neuromasts – exterior sensory organs in the zebrafish that are comparable to the sensory patches in ears. These results support the hypothesis that HARS plays a particularly important role in the vertebrate eye and ear. We aim to define the role of HARS in these sensory systems using the zebrafish as a model.