Download The Langenau Laboratory at the Massachusetts General Hospital

Cancer Research Fellowship
The Langenau Laboratory at the Massachusetts General Hospital, Boston is recruiting a
research fellow to study the role of a novel HMG box protein in regulating DNA repair
and leukemogenesis. Research will focus on using cutting edge proteomics,
biochemistry, cell biological assays, and zebrafish animal modeling.
Dr. Langenau’s research group has become a pioneer in the field pediatric cancer
research. The laboratories interests are best summarized in the following manuscripts (Moore
et al., JEM, 2016; Tang et al., Nature Communications, 2016; Blackburn et al., Cancer Cell
2014; Tang et al., Nature Methods, 2014; Chen et al., PNAS 2014; Ignatius et al., Cancer Cell
2012). Additional information about the laboratory is available at langenaulab.com.
Applicants with advanced skills in zebrafish genetics, DNA repair, proteomics, biochemistry, and
cell biological assays (including ChIP seq) are highly desired.
Candidates must have PhD and/or MD, have made significant scientific contributions through
publication of high impact papers, and be enthusiastic about science.
A curriculum vitae, list of publications, and three references should be provided as a single PDF
by December 20th, 2016 to:
David Langenau
Molecular Pathology Unit
Massachusetts General Hospital
149 Thirteenth Street, Room 6133
Charlestown, MA 02129
[email protected]
The Langenau laboratory research focus is to uncover the mechanisms driving progression and
relapse in pediatric tumors. Using novel, transgenic zebrafish models of pediatric sarcoma and
leukemia that mimic human malignancy, we have undertaken studies to discover novel
therapies by addition of drugs to the water and imaging tumor growth in live
zebrafish. Moreover, we have utilized detailed imaging studies to visualize tumor cells in live
animals and assess how cellular heterogeneity drives continued tumor growth. Capitalizing on
insights gained from our zebrafish models of cancer, we are now extending our findings to
human T-cell acute lymphoblastic leukemia and rhabdomyosarcoma.
Massachusetts General Hospital, a leading medical center located in the heart of Boston, is
consistently ranked among the top hospitals in America. The original and largest teaching
hospital of Harvard Medical School, Mass General conducts the largest hospital-based research
program in the United States and is the top recipient of research funding from the National
Institutes of Health (NIH). Mass General has long been a leader in successfully bridging
innovative science with state-of-the-art clinical medicine and topped the Nature Index list of
health care organizations for publishing more articles in high-impact journals than any other
hospital in America from February 2015 to January 2016.