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Interdisciplinary Data Science Faculty Candidate
Jinbo Xu
Toyota Technological Institute at Chicago
Thursday, April 10, 2014
12:30 PM
Goergen Hall, Room 101
Host: Prof. Jack Werren <[email protected]>
Computational Methods for Data-Driven Study of Protein Structure and Function
High-throughput sequencing has been producing a large amount of protein sequences,
but many of them are missing solved structures and functional annotations, which are
essential to the understanding of life process and diseases and also have tremendous
implications to drug discovery and design. This talk will focus on protein homology
detection and knowledge-based structure prediction, which are widely used for the
elucidation of protein structure and function as well as protein evolutionary relationship.
In particular, this talk will demonstrate how statistical machine learning (e.g.,
probabilistic graphical models) and optimization methods can be applied to address
some fundamental challenges facing protein homology detection and protein folding by
taking advantage of high-throughput sequencing.
Dr. Jinbo Xu is an associate professor at the Toyota Technological Institute at Chicago,
a computer science research and educational institute located at the University of
Chicago, and a research affiliate of the MIT Computer Science and Artificial Intelligence
Laboratory. Dr. Xu’s research lies in machine learning, optimization and computational
biology (especially protein bioinformatics and biological network analysis). He has
developed several popular bioinformatics programs such as the CASP-winning RaptorX
(http://raptorx.uchicago.edu) for protein structure prediction and IsoRank for
comparative analysis of protein interaction networks. Dr. Xu is the recipient of Alfred P.
Sloan Research Fellowship and NSF CAREER award.