Download Principal Investigator: Prof. Mehmet Fatih Yanik Post Doctoral

High-throughput Neurotechnology Group
Multi-scale
Bioengineering
Principal Investigator: Prof. Mehmet Fatih Yanik
and
Post Doctoral Students: Julio Amigo & Sayyed Azimi
Biophysics
Graduate Students: Cody Guilleland, Mark Scott, Joe Steinmeyer & Carlos Pardo
Research Scientists: Peter Eimon, Jackie Wolfrum, Stephen Sheridan
Our Approach
Our Goal
To advance our
understanding of
the function and
complexity of the
central nervous
system, and
engineer it to solve
big challenges in
medicine.
Our Strengths
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By focusing on our strengths in
engineering and physical sciences we
develop
novel
drug
screening
technologies, high-throughput imaging
and cell manipulation techniques, tissue
patterning systems, and bioinformatics
techniques to rapidly study and control
the behavior and regeneration of
neurons under biological conditions.
Robotics and automation
Neurobiology
Photonics and microscopy
Photochemistry
Image analysis
Cell and tissue culture
Whole animal screening
mRNA technologies
Microfluidic devices
Our Core Technologies
High-throughput single-cell manipulation in
brain tissue
High-throughput tissue micro-printing
technology
Vertebrate manipulation technology and
hyperdimensional phenotyping
Combinatorial Proteins
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1
Microfluidic Mixer
2
3
4
Pattern
resolution ~ 0.5
μm
6
Inducing synaptic connections
in microfluidic chips
Generating transplantable human neurons by
reprogramming skin cells to stem cells
Superior efficiency
Single cell capture
Single fibroblasts
from Parkinson’s patient
Repeated 12-day delivery of
Oct4, Sox2, Klf4, c-Myc mRNA
Stem cell markers (day 24)
In vitro
Neuronal regeneration after
precise in vivo laser nanosurgery
5
Transplanted to animals  Generated all germ layers
In vivo
40x
0.95NA
Our Team