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Olfactory receptors influence the targeting of sensory axons to discrete glomeruli in the olfactory bulb. (Adapted, with permission, from Sanes and
Yamagata 2009.)
A. Each olfactory receptor neuron expresses one of approximately 1,000 possible odorant receptors. Neurons expressing the same receptor are
distributed sparsely throughout the olfactory epithelium of the nose. The axons of these neurons form synapses with target neurons in a single glomerulus
in the olfactory bulb.
B. In mouseSource:
mutantsFormation
in which an
odorant
receptor
gene has been
deleted,
the olfactory
neurons
that would have expressed the gene send their axons to
and
Elimination
of Synapses,
Principles
of Neural
Science,
Fifth Editon
other glomeruli,
in
part
because
these
neurons
now
express
other
receptors.
Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available
C. When one odorant
receptor gene replaces
another May
in a 10,
set 2017
of olfactory sensory neurons, their axons project to a new glomerulus. Odorant receptor
at: http://mhmedical.com/
Accessed:
expression may
set the
overall
activity level
of the neuron,
influencing the nature and level of expression of axonal guidance and recognition
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McGraw-Hill
Education.
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molecules.)