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Transcript
Organization of the anterior and posterior pituitary gland. Hypothalamic neurons in the supraoptic (SON) and paraventricular (PVN) nuclei synthesize arginine vasopressin (AVP) or oxytocin (OXY). Most of their axons project directly to the posterior pituitary, from which AVP and OXY are secreted into the systemic circulation to regulate their target tissues. Neurons that regulate the anterior lobe cluster in the mediobasal hypothalamus, including the PVN and the arcuate (ARC) nuclei. They secrete hypothalamic releasing hormones, which reach the anterior pituitary via the hypothalamic-adenohypophyseal portal system and stimulate distinct populations of pituitary cells. These cells, in turn, secrete the trophic (signal) hormones that regulate endocrine organs and other tissues. See Table 38–1 for abbreviations. Source: Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e Citation: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e; 2016 Available at: http://mhmedical.com/ Accessed: May 04, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
