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A) The linearized double-stranded DNA genome of KS virus showing important genes of the lytic cycle. The genome contains 87 open reading frames
(ORFs) coding for latent proteins, reactivation proteins, and structural proteins. Host genes that help the virus evade immune surveillance and inhibit
apoptosis have been acquired from chromosomes through a process of molecular piracy. These genes include vFLIP, vBcl-2, v-cyclin, interferon response
factors (IRFs), and membrane cofactor protein (MCP), v-IL6, macrophage inflammatory protein (MIP) chemokines, LANA, and v-IL8R (vGCR). Genes
specifying LANA, K1/KIST, and K15/LAMP maintain the viral episome in the latent state and are analogous to EBV proteins (EBNA1, LMP1, LMP2) with
similar functions. B to E) Skin lesions associated with KS. Lesions present as red blotches on the skin caused by the infection of spindle cells.
Source: Oncogenic Viruses and Tumor Viruses, The Basic Science of Oncology, 5e
Angiogenesis occurs in the surrounding tissue. Panels B and C are examples of endemic or Mediterranean KS, while panels D and E illustrate epidemic or
Tannock IF, Hill RP, Bristow RG, Harrington L. The Basic Science of Oncology, 5e; 2016 Available at: http://mhmedical.com/
AIDS-relatedCitation:
KS.
Accessed: August 11, 2017
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