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Gene Regulation Some genes are regulated (turned off and on) by repressor proteins While others use proteins that enhance the rate of transcription. Operons are generally not found in Eukaryotes. Gene regulation is controlled individually and have regulatory sequences that are much more complex that those of the lac operon. TATA box is found in Eukaryotic genes. It helps position RNA polymerase to begin transcription of the DNA. The promoter is found just before the TATA box. Cell Specialization. Multicellular organism carry the complete genetic code in their nucleus but only a tiny fraction of the available genes needs to be expressed in cells of different tissues in the body. HOX Genes tells the cells of the body which organs and structures they should develop as the body grows.