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Effect of protein composition on gastric emptying rate in children with cerebral palsy. Anne Charlotte Brun* 1., Asle W. Medhus 2., Groa B. Johannesdottir 3., Edda Olafsdottir 4., Jarle Rugtveit 1., Beint S. Bentsen 1., Ketil Størdal 5. 1. Barnemedisinsk avdeling, ullevål universitetssykehus. 2. Gastromedisinsk avdeling, ullevål universitetssykehus. 3. Barnemedisinsk avdeling, Akureyri hospital, Island. 4. Barnemedisinsk avdeling, Haukeland universitetssykehus. 5. Barneavdelingen, Sykehuset Østfold Fredrikstad (permisjon). Rationale: Dysmotility, nausea and vomiting are common among children with cerebral palsy (CP), but data on this issue is scarce. Aim: To examine the influence of protein composition on rate of gastric emptying and gastric electrical activity. Methods: 15 children with CP, mean age 10.7 years (range 5-15), using percutaneous gastrostomy (PEG) as their main route of feeding, received four liquid test meals on separate days in random order. The meals were made of a carbohydrate and fat base plus one of four protein modules (casein (A), hydrolysed whey (B), amino acids (C) and 40% casein/60% whey (D)) with a total energy of 1 kcal/1ml. The protein equivalent was 2.8g/100ml, carbohydrate 12.0g/100 ml and fat 4.5g/100 ml. Volume (200ml), temperature and feeding time were the same for all meals. The 13C octanoic acid breath test was applied to assess gastric emptying, and electrogastrography (EGG) was used to monitor electrical activity. Wilcoxon test was applied and results are given as median (range). Results: The rate of gastric emptying assessed by time until 50% of the meal had emptied (T1/2) was as follows: Test meal A 153.9 min.(22.3 – 776.4), B 82.0 min. (5.5 – 626.5), C 74.4 min (31.9 – 343.0) and D 63.3 min.(15.8 – 182.8). The difference of T1/2 of test meal A and B was 24.7 min.(-542.4 – 749.3) (p=0.078), of A and C 43.0 min.(-189.1 – 742.1) (p=0.069), and of A and D 78.0 min.(-15.7 – 630.1) (p=0.001). Postprandial EGG dominant frequency decreased for formula A, but increased for formula B, C and D. Conclusion: In patients with CP using PEG, gastric emptying is influenced by type of protein in the meal. A meal with 40% casein/60% whey was emptied significantly faster than a meal with casein, and the same tendency was observed for hydrolysed whey and amino acids. Furthermore, there seems to be an association between gastric emptying and the dominant frequency of the EGG. * Lege i spesialisering, Barnemedisinsk Avdeling, Ullevål Universitetssykehus.