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9853 Pacific Heights Blvd. Suite D. San Diego, CA 92121, USA Tel: 858-263-4982 Email: [email protected] 36-1577: Monoclonal Antibody to UACA / Nucling (Nuclear Membrane Marker)(Clone : AE-5) Clonality : Monoclonal Application : FACS,IF,WB Reactivity : Human,Mouse Gene : UACA Gene ID : 55075 Uniprot ID : Q9BZF9 Format : Purified Alternative Name : UACA,KIAA1561 Isotype : Mouse IgG1 Kappa Immunogen Information : Nuclei of myeloid leukemia biopsy cells Description UACA (Uveal Autoantigen with Coiled-coil domains and Ankyrin repeats) is a 1,416 amino acid nuclear membrane protein. It was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves' disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway. Product Info Amount : 100 µg Purification : Affinity Chromatography Content : 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. Storage condition : Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles. Application Note Flow Cytometry (0.5-1µg/million cells in 0.1ml); Immunofluorescence (0.5-1.0µg/ml); Western Blot (0.5-1µg/ml); Optimal dilution for a specific application should be determined. Western Blot of A549 Cell Lysate using UACA / Nucling Monoclonal Antibody (AE-5) For Research Use Only. Not for use in diagnostic/therapeutics procedures.