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Protein Structure (Part 1) Proteins are heteropolymers •  hetero – (from Greek) other, another different •  polymer – a molecule consis=ng of repea=ng units 20 Naturally occurring amino acids •  differ in the nature of their “sidechains” •  these proper=es, and the sequence in which they occur determine the “shape” of the protein …AGARTWLYLIPDNLDK… Primary structure Secondary structure α helix β sheet Ter=ary structure Quaternary structure Increasing Complexity Protein Structure Heirarchy Helices and Sheets Repea=ng units of secondary structure that allow for regular networks of hydrogen bonds between backbone atoms. Go to Protein Structure Worksheet and get some hands-­‐on experience looking at protein structures! Protein Structure Links •  PDB (Protein Data Bank): –  hZp://www.pdb.org •  SCOP (Structural Classifica=on of Proteins) –  hZp://scop.mrc-­‐lmb.cam.ac.uk/scop/ •  CATH (Protein Structure Classifica=on Database) –  hZp://www.cathdb.info/