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INCI: sodium olivoyl glutamate, aqua FUNCTION: PEG-free, non ethoxylated, vegetable surfactant based on olive oil. It is ideal for use in combination with Olivoil Surfactant as it optimises its detergent action. Creates excellent abundant and stable foam. DESCRIPTION: It is obtained through the combination of fatty acids from olive oil, as far as the lipophilic portion is concerned, and the sodium salt of the amino-acid glutamic acid, obtained from wheat gluten, for the hydrophilic portion. The result is a lipo-amino-acid with surface activity, mild detergent activity with excellent foaming power, suitable for shampoos, soaps, bath foam, as possible examples. tensid / surfactant Olivoil Glutamate Surfactant Hair Care Ecocert Tensid Cosmetics TRADENAME Olivoil Glutamate Surfactant DESCRIPTION Designed to perform a mild detergent action with perceivable skin improvements, it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special properties like antimicrobial effects against a wide range of microorganisms, and can be considered non toxic and only mild irritants. In cosmetics, they satisfy the need of surfactants with multi-functional and bio-compatible characteristics. INCI & GENERAL COMPOSITION sodium olivoyl glutamate (Biopolymer) aqua (CAS 7732-18-5) pH 6,0 - 8,0 APPEARANCE clear liquid COLOR colorless / pale yellow ODOR slight, neutral APPLICATIONS Between 2 and 10% in skin cleansing products (foam bath, shampoos). The product is ready to use and does not require any pre-treatment. The addition to the bulk at temerature below 40°C is recommended. Olivoil Glutamate, when used as a delicate surfactant in shampoo, bubble bath and body soaps, creates excellent abundant and stable foam. It can be used in a wide range of cleansing cosmetics, for obtaining creamy touch and balanced cleansing power. It has an optimal skin detergent action without harming or irritating it; while, on the contrary, improving the sensorial characteristics of the detergent formula. This surface-active agent is ideal for use in combination with Olivoil Surfactant as it optimises its detergent action. Olivoil products are used in association with aggressive traditional surfactants (like SLES reducing its irritant effect) in percentages ranging from 2% to 15% depending on the desired effect. CERTIFICATION Ecocert certification since Nov 2006 SHELF LIFE 12 month in the original containers General Info Oliveoil Glutamate is a non ethoxylated, vegetal-derived surfactant. It is obtained through the combination of fatty acids from olive oil, as far as the lipophilic portion is concerned, and the sodium salt of the amino-acid glutamic acid, obtained from wheat gluten, for the hydrophilic portion. The result is a lipo-amino-acid with surface activity, mild detergent activity with excellent foaming power, suitable for shampoos, soaps, bath foam, as possible examples. Once applied onto the skin, for the hydrolytic action of the stratum corneum enzymes, the external amide bond is hydrolyzed and the active agent is therefore separated in the constituting molecules: fatty acids and glutamic acid. The free aminoacid becomes part of NMF, while fatty acids, especially oleic and palmitoleic, for their high skin compatibility, enrich the composition of cell membranes in a direct way. Designed to perform a mild detergent action with perceivable skin improvements, it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special properties like antimicrobial effects against a wide range of microorganisms, and can be considered non toxic and only mild irritants. In cosmetics, they satisfy the need of surfactants with multi-functional and bio-compatible characteristics. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: cetearyl alcohol, glyceryl oleate, glyceryl stearate, potassium olivoyl hydrolyzed wheat protein FUNCTION: PEG-free, non ethoxylated, vegetable emulsifier based on olive oil. DESCRIPTION: It is a lipoproteic emulsifier that combines the unique fatty acid profile of olive oil with the characteristic affinity of hydrolysed wheat proteins toward the skin surface. Suitable for sensitive and delicate skin. It is useful to build-up anisotropic lamellar phases O/W from vegetal oils, by means of totally natural ingredients. Emulsions with very pleasant white appearance and characteristic softtouch, stable at high temperature, without addition of co-emulsifiers. Immediate perceptions of skinsmoothness, softness and silkiness. emulsifier Olivoil Emulsifier Skin Care Baby Care Ecocert Emulsifier Cosmetics DESCRIPTION olivoil emulsifier is a non-ethoxylated, vegetal derived surfactant that combines the unique fatty acid profile of olive oil with the characteristic affinity of hydrolyzed wheat proteins toward the skin surface. the result is a new emulsifier structure with high skin compatibility and maximum biodegradability. olivoil emulsifier is based on olivoyl hydrolyzed wheat protein, a lipo-protein with a fatty amide structure, showing high inter-facial activity. the result is an ‘emulsifier base’ with an outstanding emulsifying power. this is due to its ability to mimic the ordered aggregation of water and oil in natural systems: the liquid crystal structure. in this manner, extremely fine and very stable emulsions are obtained, with the oil droplets surrounded by bi-layers of amphiphilic molecules which strengthen the interface stability, thus avoiding the coalescence. with olivoil emulsifier, the concepts of skin-compatible liquid crystals and skin water-management become a reality. the hydro-lipidic balance of the skin, which is significantly lowered by traditional emulsifiers, is only barely altered. the increased capacity of the skin to retain moisture, after the application of an emulsion realized with olivoil emulsifier can be determined. furthermore, the lipidic moiety of the olivoil emulsifier, thanks to the relevance of saturated and unsaturated fatty acids from olive oil, can provide a significant contribution to the anti-aging effect of the whole cosmetic product. INCI & GENERAL COMPOSITION Potassium Olivoyl Hydrolyzed Wheat Protein, Cetearyl Alcohol (CAS 67762-27-0), Glyceryl Oleate (CAS 25496-72-4), Glyceryl Stearate (CAS 31566-31-1) pH 6,0 - 7,0 APPEARANCE solid COLOR ivory white ODOR faint, characteristic CERTIFICATION Ecocert certification since Nov 2006 SHELF LIFE 12 month in the original containers APPLICATIONS It is suitable for sensitive and delicate skin (dry skin & baby skin products). furthermore, it is useful to build-up anisotropic lamellar phases o/w from vegetal oils, by means of totally natural ingredients. emulsions with very pleasant white appearance and characteristic softtouch, stable at high temperature, without addition of co-emulsifiers, can be obtained. their outstanding skin-feel is a very important ‘marketing plus’: immediate perceptions of skin smoothness, softness and silkiness are easily noticeable during and after application. 3-10% in skin-care products (o/w emulsions); amounts from 5-10% are suggested to reach thick emulsions; while 2-5% is usually necessary to otain fluid emulsions (with water phase gelification) pH range: the optimum stability is between 5-7 In-Vitro Evaluations LPO586: it does not induce any lipo-peroxidation In-Vivo Evaluations Skin-irritation: no reaction (20 volunteers, epicutaneous patch-test, according to draize classification) © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: sodium olivoyl glutamate, aqua FUNCTION: PEG-free, non ethoxylated, vegetable surfactant based on olive oil. It is ideal for use in combination with Olivoil Surfactant as it optimises its detergent action. Creates excellent abundant and stable foam. DESCRIPTION: It is obtained through the combination of fatty acids from olive oil, as far as the lipophilic portion is concerned, and the sodium salt of the amino-acid glutamic acid, obtained from wheat gluten, for the hydrophilic portion. The result is a lipo-amino-acid with surface activity, mild detergent activity with excellent foaming power, suitable for shampoos, soaps, bath foam, as possible examples. tensid / surfactant Olivoil Glutamate Hair Care Ecocert Tensid Cosmetics TRADENAME Olivoil Glutamate DESCRIPTION Designed to perform a mild detergent action with perceivable skin improvements, it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special properties like antimicrobial effects against a wide range of microorganisms, and can be considered non toxic and only mild irritants. In cosmetics, they satisfy the need of surfactants with multi-functional and bio-compatible characteristics. INCI & GENERAL COMPOSITION sodium olivoyl glutamate (Biopolymer) aqua (CAS 7732-18-5) pH 6,0 - 8,0 APPEARANCE clear liquid COLOR colorless / pale yellow ODOR slight, neutral APPLICATIONS Between 2 and 10% in skin cleansing products (foam bath, shampoos). The product is ready to use and does not require any pre-treatment. The addition to the bulk at temerature below 40°C is recommended. Olivoil Glutamate, when used as a delicate surfactant in shampoo, bubble bath and body soaps, creates excellent abundant and stable foam. It can be used in a wide range of cleansing cosmetics, for obtaining creamy touch and balanced cleansing power. It has an optimal skin detergent action without harming or irritating it; while, on the contrary, improving the sensorial characteristics of the detergent formula. This surface-active agent is ideal for use in combination with Olivoil Surfactant as it optimises its detergent action. Olivoil products are used in association with aggressive traditional surfactants (like SLES reducing its irritant effect) in percentages ranging from 2% to 15% depending on the desired effect. CERTIFICATION Ecocert certification since Nov 2006 SHELF LIFE 12 month in the original containers General Info Oliveoil Glutamate is a non ethoxylated, vegetal-derived surfactant. It is obtained through the combination of fatty acids from olive oil, as far as the lipophilic portion is concerned, and the sodium salt of the amino-acid glutamic acid, obtained from wheat gluten, for the hydrophilic portion. The result is a lipo-amino-acid with surface activity, mild detergent activity with excellent foaming power, suitable for shampoos, soaps, bath foam, as possible examples. Once applied onto the skin, for the hydrolytic action of the stratum corneum enzymes, the external amide bond is hydrolyzed and the active agent is therefore separated in the constituting molecules: fatty acids and glutamic acid. The free aminoacid becomes part of NMF, while fatty acids, especially oleic and palmitoleic, for their high skin compatibility, enrich the composition of cell membranes in a direct way. Designed to perform a mild detergent action with perceivable skin improvements, it is the ideal partner of Olivoil Surfactant. Lipo-aminoacids show special properties like antimicrobial effects against a wide range of microorganisms, and can be considered non toxic and only mild irritants. In cosmetics, they satisfy the need of surfactants with multi-functional and bio-compatible characteristics. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: potassium olivoyl hydrolyzed wheat protein, aqua FUNCTION: PEG-free vegetable surfactant based on olive oil. Compatible with all traditional surfactants. DESCRIPTION: Olivoil Surfactant is a non ethoxylated and non sulphated vegetal-derived surfactant. It is a lipoprotein obtained through condensation between the carboxyl group of fatty acids derived from olive oil and the amino group of the hydrolyzed wheat proteins. tensid / surfactant Olivoil Surfactant Skin care Hair Care Ecocert Tensid Cosmetics TRADENAME Olivoil Surfactant DESCRIPTION Olivoil Surfactant is a new generation surfactant, with a mild cleansing ability and is compatible with all traditional surfactants and most standard cosmetic ingredients. INCI & GENERAL COMPOSITION potassium olivoyl hydrolyzed wheat protein (Biopolymer) aqua (CAS 7732-18-5) pH 6,8 - 8,0 APPEARANCE clear liquid COLOR yellow ODOR faint, characteristics APPLICATIONS Between 2 and 20% in skin cleansing products (foam bath, shampoos, baby care and personal hygiene cosmetics). Olivoil products are used in association with aggressive traditional surfactants (like SLES reducing its irritant effect) in percentages ranging from 2% to 15% depending on the desired effect. CERTIFICATION Ecocert certification since Nov 2006 In-Vivo Evaluations Red Blood Cell test: non irritation LPO586: it does not induce any lipo-peroxidation Skin irritation (according to Draize classification): no reactions SHELF LIFE 12 month in the original containers General Info To merely reduce the irritant effect of traditional surfactants, low percentages of Olivoil products (2 - 5%) may be employed. Higher percentages of Olivoil products are suggested (5 - 15%) where an immediate feel of hydration, smoothness and softness wants to be additionally achieved. Moreover, the higher is the percentage of Olivoil used, the higher is the sensory eudermic effect obtained. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: calcium-hydroxyapatite, aqua. FUNCTION: adhesion to and reduction of plaque, repair of microscopic surface damage, remineralisation of subsurface DESCRIPTION: calcium hydroxyapatite is based on a formulation designed to significantly enhance the natural salivary remineralisation of dental enamel. it is a good alternative to those patients unwilling to use fluorides as part of their dental care regime. features - dental sensitivity - remineralization and filling of surface lesions - plaque clinical-physical removal - acid antierosion - bio-available calcium and phosphate ions - boosts natural ability of saliva to remineralise tooth structure alleviates - teeth erosion - dental white lesions - rampant caries - dental effects of acidic mouth - enamel problems in newly-erupted teeth functional ingredient Calcium Hydroxyapatite / KALIDENT natural remineralising Oral-care Cosmetics TRADENAME Kalident DESCRIPTION the regular use of kalident-calcium hydroxyapatite over an extended period can do much to alleviate problems caused by excessive demineralisation of dental enamel. the use of kalident-calcium hydroxyapatite helps preventing caries or to stabilise rampant caries, counteracting the consequences of poor oral hygiene, acid foods and carbonated drinks. it can help prevent the dental consequences of xerostomia or sjogren’s syndrome. it can even assist in the reversal of dental erosion and its adverse consequences. 1. adhesion to and reduction of plaque kalident-calcium hydroxyapatite has a strong propensity to bind with protein, and adheres to plaque bacteria and glycoproteins in the oral cavity, facilitating their removal on rinsing the mouth after brushing. this feature of hydroxyapatite has been enhanced by reduction of its particle size through nanotechnology, so enormously increasing the surface area to which bacterial proteins attach. 2. repair of microscopic surface damage kalident-calcium hydroxyapatite also acts as a filler, restoring minute cracks and scratches in surface tooth enamel. reduction of its size to nanometre level has enhanced this ability of hydroxyapatite to enter and rebuild the crystalline network at the surface defects in the enamel. by filling minute surface lesions and restoring smoothness to the enamel, kalidentcalcium hydroxyapatite also reduces the number of sites on the tooth surface to which plaque is likely to adhere. results of research in this area were presented at the iadr in early 2004. 3. remineralisation of subsurface kalident-calcium hydroxyapatite, having almost the same composition as our teeth, directly provides mineral to demineralised subsurface areas of the tooth (incipient caries), restoring the enamel to its nearnatural state, without changing the composition of the enamel. this is in contrast to fluorides, which are not true remineralising substances by themselves, but promote teeth remineralisation by salivary calcium phosphate, by creating a new substance, fluorapatite, on the tooth surface. fluorides tend to form a coating on the surface of the enamel, in contrast to hydroxyapatite, which tends to restore subsurface lesions from the deeper part of the lesion first. this deep restorative effect has been enhanced by the reduction of the hydroxyapatite particle size to two-figure nanometer size, facilitating their deeper penetration into the enamel. 12 23 od No uc ts ( C) GULA TION (E 30 Nov 2009 ) RE INCI & GENERAL COMPOSITION hydroxyapatite (CAS 1306-06-5), aqua (CAS 7732-18-5) pH 7 - 7,6 APPEARANCE solid viscose suspension COLOR white ODOR slightly characteristic SHELF LIFE 12 month /20 09 on cos me tic pr the Clinical Evidence - interaction of small crystal form of hydroxyapatite with mutans streptococci - a new enamel restoring agent for use after pmtc - a new enamel restoring agent for use after bleaching - adsorption effect of hydroxyapatite to oral streptococci - remineralization effects of nanohydroxyapatite-containing dentifrice: a ph-cycling study using supernatant - remineralization by nanohydroxyapatite-containing dentifrice: a ph cycling study using slurry - post-bleach stain inhibition by nano-hydroxyapatite: a cyclical staining test - restoration of post-bleach enamel gloss using a non-abrasive, nano-hydroxyapatite conditioner - effect of hydroxyapatite toothpaste on vital tooth color - in vitro studies of dental plaque formation: adsorption of oral streptococci to hydroxyaptite. General Info over half the dry weight of human bone, 97% of dental enamel and 70% of dentine is comprised of hydroxyapatite. human saliva, rich in calcium and phosphate ions, is a saturated solution of hydroxyapatite. natural and synthetic hydroxyapatite have a strong affinity with the human body, and are used widely in orthopedic and dental applications (such as bone augmentation, dental cement, coatings for implants, etc.), as well as in foods, as a readily absorbed dietary calcium phosphate supplement. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: Polyglyceryl-4 Caprate FUNCTION: This Polyglycerol Ester for outstanding innovative cosmetic formulations; multi-purpose ester with plenty of benefits and properties DESCRIPTION: Soldoc PG410 is a liquid low viscose non-ionic surfactant. based on linear polyglycerol and fatty acid. It Is PEG-free, hydrophilic, compatible with all anionic & non-ionic surfactants and has excellent solubilizing effects with outstanding surface-active properties. With Soldoc PG410 it is easy to formulate emulsions containing essential oils. It is high substantive, has skin-smoothening effects, gives fantastic sensorial skin feeling and is non-sticky. 13-15 functional ingredient Soldoc PG410 Emulsifier Solubilizer Thickener Ester Wet Wipes Shower Gel / Creme Deodorant Shampoo Baby Care Toiletries Skin care Hair Care Cosmetics TRADENAME SOLDOC® PG410 DESCRIPTION Universal emulsifier. Provides thickening properties. Acts as deodorizing agent. It is a multi-purpose ester and has plenty of benefits and properties. INCI & General composition Polyglyceryl-4 Caprate CAS 160391-93-5 Properties - Additive - Deodorizing agent - Humidity regulator - Keeps natural skin balance - Not irritant - Moisturizer - Refatting agent - Skin smoothing - Solubilizer - Surfactant - Thickening agent for toiletries - Universal Emulsifier (O/W & W/O ) Applications - Liquid soaps - Natural cosmetics - Oil Bath - Shampoos - Toiletries - Wet wipes Benefits - Cold processable - Easy to process - Good biodegradibility - No nitrosamine formation - Multifunctional - PEG free - Sustainable (based on native raw material - Toxicological safe recommended concentration: 2 - 8% © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: Neopentyl Glycol Diethylhxanoate FUNCTION: functional, sustainable, ecological and non toxic ester with excellent pigment dispersing properties and, due to it’s sensoric attributes an ideal texture agent DESCRIPTION: Soldoc VF8 is a very liquid low viscose non-volatile organic functional emollient based on Neopentyl Glycol and fatty acid. It is used as Cyclomethicone alternative as cyclomethicones are suspicious to aid cancer and having mutagenic impact. Compared to most silicone components a dosage use of only 75% Soldoc is needed to achieve similar skin feeling. functional ingredient Soldoc VF8 Ester Emollient Silicon-Replacement Deodorant Lipsticks & Glosses Creams & Lotions Oil-free formulations Skin care Sun Care Lip Care Hair Care Baby Care Toiletries Color Cosmetic Cosmetics TRADENAME SOLDOC® VF8 DESCRIPTION Soldoc VF8 is a very liquid low viscose non-volatile organic functional emollient based on Neopentyl Glycol and fatty acid. Soldoc VF8 is used as Cyclometicone alternative as cyclometicones are suspicious to aid cancer and having mutagenic impact. Compared to most silicone components a dosage use of only 75% Soldoc VF4/18 is needed to achieve similar skin feeling. The Soldoc VF8 is a functional, sustainable, ecoloigical and non toxic ester with excellent pigment dispersing properties and, due to it’s sensoric attributes an ideal texture agent. Furthermore soluble in most hydrophbic solvents. The Neopentyl glycol diethylhexanoate is additionally perfect for developing sun screens and body lotions to feature a rich, clean and long-lasting emolliency even for formulatione with high payload of pigments. Neopentyl glycol diethylhexanoate is applicable in powder foundation, lipstick, gloss and skin care. Neopentyl glycol diethylhexanoate enhanced wearability to your facial care products and color cosmetics INCI & General composition Neopentyl Glycol Diethylhxanoate REACH * GM124711-44 | CAS 28510-23-8 | EINECS 249-060-1 Properties Binding (agent ), Excellent solvency, Fast absorbance, High /good slip, High solubilizer for UV organic absorbers / Carrier, High spreadability, Light soft skinfeel, Moisturizer for oily skin, Non-greasy skinfeel, No unpleasant residue, Silky dry afterfeel / Velvety, Tack-free Applications Decorative Cosmetics/Make-up (Blushes / Balm, Eyeliners, Eye Shadows, Face powder, Glossy / Ultra Glossy, Lipsticks, Liquid Foundations) Face & Body Care (Baby Products, Creams Lotions, Make-up removers) Hair care (Conditioners, Shampoos, Styling) Sun care (After-sun, Protection, Self-tanning, Tanning Oil) Toiletries (Shaving, Aftershave & toners, Anti-perspirantes & Deodorants, Oral care, Shower & Bath) Benefits Easy to process Good biodegradibility High oxidative stability PEG free Sustainable (based on native raw material) Toxicological safe Spreadab Solubility ility 10 9 8 7 6 5 4 3 2 1 0 Polarity Polarity INCI Appearance Clear, Ciclomethicone SOLDOC VF8 Surface Surface Tension Tension Hydration Hydration Product Designation Viscosity Viscosity D5 Soldoc VF8 Cyclopentasiloxane Neopentyl Glycol Diethylhexanoate colorless liquid colorless liquid Molecular Weight Viscosity, mPa·s Permittivity Interfacial Tension vs. H20, mN/m 395 3,8 2,6 356 11,7 3,9 29,5 19,2 Contact Angle on Vitro-Skin @ 1s, degrees 2,3 18,2 0,076 0,061 Coefficient of Friction © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: hydroxyapatite, aqua FUNCTION: Skin-friendly solid actives Sun filter booster DESCRIPTION: Apalight is constituted of hydroxyapatite particles activated with trace elements: an Association of (Zn, Mn, Mg) (Ca)5 (PO4)3(OH) (Lactate). Bio-functional skin-friendly mineral solid active in sunscreen cosmetics. Apalight, thanks to its bio-compatibility with human body and skin, is a very effective sun-filter booster, superior to Titanium dioxide, without any blue-white appearance and lower costs; moreover are avoided the typical problems of intolerance and loss of efficacy affecting those ingredients ,like micronized solids, that tend to diffuse in depth interfering with skin metabolism actives / emotives APALIGHT SPF-Booster Sun Care Anti-Aging Natural Cosmetics TRADENAME Apalight APPEARANCE WHITE VISCOUS POWDER SUSPENSION CONCENTRATION 28 - 30% suspended solids GENERAL COMPOSITION Association of (Zn, Mn, Mg) (Ca)5 (PO4)3(OH) (Lactate) pH OF SUSPENSIONS 7-8 INCI: HYDROXYAPATITE, AQUA PRESERVATIVE Phenonip (other available) PARTICLE SIZE inf. 100nm (It is a complex of nano-particles and not.) 12 23 od No uc ts ( C) GULA TION (E 30 Nov 2009 ) RE Apalight is not a nanomaterial by definition of the new EC Regulation No. 1223/2009 of 30 Nov 2009 /20 09 on cos me tic pr STORAGE CONDITIONS Keep in original containers, well closed, in a cool (minimum suggested temperature 14° C. max 30° C.), dry, well ventilated and clean site. APPLICATIONS SunCare-Products, Anti-Aging-Products RESULTS Evaluations show that, when introduced into several types of sunscreen formulas, APALIGHT gave better performances than TiO2, in values variable from 2 to 18% higher than standard sunscreen grade TiO2. All tests were carried out using the COLIPA method. In other words, APALIGHT showed seemingly better or at least comparable sunscreen efficacy as micronized titanium dioxide. In the field of anti-age efficacy, the material proved to perform a statistically significant soft-focus effect (by sensory evaluation) a statistical decrease of deep wrinkles and a tendential decrease of average rugosity (by skin replica). Improved biological elasticity and visco-elastic coefficient (measured by Cutometer) were the influenced elasticity parameters. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: leontopodium alpinum meristem cell culture, glycerine, xanthan gum FUNCTION: the truly effective anti-aging solution: reduction of eye contour wrinkles, prevention of collagen loss, firming and restructuring treatments, prevention of aging and photo-aging DESCRIPTION: Edelweiss is a herbaceous plant of the family Asteraceae and it grows spontaneously on mountain ranges from Pyrenees and Alps to Himalaya. It is a rare and strictly protected plant anti-oxidant anti-hyaluronidasic anti-collagenasic natural actives Leontopodium alpinum Stems G edelweiss anti-aging Moisturizing Natural Skin regeneration Skin-care Cosmetics DESCRIPTION Produced in a unique process able to physiologically orientate the production of specific substances involved in defensive responses of the plant against environmental physical and biological stress. Through the in vitro culture of plant stem cells in protected and highly controlled conditions achieves the production of these substances with considerable biological properties. Quercitin Resveratrol Vitamin C Trolox Chlorogenic acid 3,5-dicaffeoylquinic acid Leontopodic acid B Leontopodic acid A HTN™ technology identification of specific substances with high biological activities. Leontopodic acids A and B, chlorogenic acid, 3,5-dicaffeoylquinic acid: antioxidant, antihyaluronidasic, anti-collagenasic activity. Phytosterols, amino acides, polysaccharides: moisturizing and nutrients. ANTI-OXIDANT ACTIVITY Leontopodium alpinum stems is rich of substances with antioxidant activity higher than that of common natural antioxidant benchmarks. (See picture 1) * TEAC (Trolox Equivalent Antioxidant Capacity) assay measures the antioxidant capacity of a substance compared with that of Trolox (set as 1). ANTI-HYALURONIDASIC ACTIVITY Thanks to the synergistic effect of its constituents, Leontopodium alpinum stems GTM inhibits hyaluronidase far more efficiently than purified leontopodic acid B.** (See picture 2) ANTI-COLLAGENASIC ACTIVITY Leontopodium alpinum stems inhibits collagenase thus limiting collagen degradation and skin firmness loss.** (See picture 3) ** This test has been performed on the powder form of Leontopodium alpinum cell cultures in order to avoid experimental interferences. 0 0,5 1 1,5 2 2,5 3 3,5 TEAC units (Trolox Equivalent Antioxidant Capacity) assay measures the antioxidant capacity of a substance compared with that of Trolox 100 % hyaluronidase inhibition 90 80 70 60 50 40 30 20 10 0 0,1 0,2 0,4 0,8 STEMS 0,8 mg/mL leontopodic acid B 100 % collagenase inhibition 90 80 70 60 50 40 30 20 10 0 0,5 INCI & GENERAL COMPOSITION Glycerine, Leontopodium alpinum meristem cell culture, xanthan gum. 1 mg/mL Recommended Concentration: 0,5 – 5 % Formulation guidelines: Compatible with O/W emulsions, serum, ... pH ≤6,0 introducing during the cooling phase. APPEARANCE yellow amber to light brown coloured liquid with characteristic odour Total aflatoxins absent GMO absent Pesticides absent Microbiological Specifications Total microbial count: bacteria < 100 UFC/g fungi < 100 UFC/g Packaging 1 Kg Storage Store the product in the original, well closed container, in a cool, dry area and protected from light Shelf life 12 months Cosmetic Uses reduction of eye contour wrinkles prevention of collagen loss firming and restructuring treatments prevention of aging and photo-aging the Clinical Evidence 20 subjects, twice a day face treatment of 40 days with a O/W cream containing 1% of Leontopodium alpinum stems at 20 and 40 days microprofile evaluation of the eye contour area by skin scanner. Leontopodium alpinum stems reduces by 15% wrinkle depth of the eye contour area after only 20 days of treatment. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: Echinacea angustifolia cell culture extract, Maltodextrin FUNCTION: protection & renewal of sensitive & tired skin DESCRIPTION: Echinacea angustifolia cell culture extract titrated at 25% of echinacoside. anti-oxidant activity anti-inflammatory activity stimulation of collagen production natural actives Echigena 25 Echinacea angustifolia powder natural skin-care Cosmetics 1 Echinacoside Trolox Vitamin C Rutin 0 0,25 0,5 0,75 1 1,25 1,5 1,75 2 TEAC units* 2 30 % collagen vs control DESCRIPTION echinacea angustifolia is a herbaceous plant native to north america, considered efficacious to heal cold and flu, wounds and inflammatory processes, and as a stimulant for the immune system. these activities are provided by a variety of chemical substances including polysaccharides and phenolic derivatives, such as echinacoside, a compound belonging to the family of the phenylpropanoids. htn™ technology easier purification of echinacoside, present in very low amounts in plant tissues, to make a final product with high biological activities. anti-oxidant activity echinacoside has a considerable antioxidant activity higher than that of common natural antioxidant benchmarks. (see picture 1) * teac (trolox equivalent antioxidant capacity) assay measures the antioxidant capacity of a substance compared with that of trolox (set as 1). stimulation of collagen production echigena 25tm stimulates the synthesis of new collagen on in vitro cultures of human fibroblasts. (see picture 2) anti-inflammatory activity echigena 25tm significantly inhibits the production of the biological messenger nitric oxide (no), thus limiting the inflammation processes and controlling blood vessel tone. (see picture 3) 25 20 15 10 5 0 100 200 µg/mL cosmetic uses treatments for sensitive skins protection from external stresses boosting skin renewal % NO inhibition production 100 inci echinacea angustifolia (asteraceae) cell cultures extract excipient: maltodetrin 80 70 60 50 40 30 20 10 0 recommended concentration: 0,2 - 1% 3 90 100 200 400 formulation guidelines: compatible with o/w emulsions, serum, ... ph ≤ 5 introducing during the cooling phase. appearance amber-coloured powder with characteristic flavour solubility freely soluble in water (eur. ph. 5th edition) shelf life 24 months store the product in the original, well closed container, in a cool, dry area and protected from light © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. µg/mL INCI: buddleja davidii meristem cell culture, glycerine, xanthan gum FUNCTION: anti-oxidant, anti-inflammatory, photoprotective & anti-collagenasic activity, moisturizing & nutrients DESCRIPTION: preparation of 20% of buddleja davidii stem cells in plant glycerine, without preservatives. in the traditional medicine plants of genus buddleja are used for their wound healing, anti-inflammatory and anti-bacterial properties. through the in vitro culture of plant stem cells, we achieve the production of these substances with considerable biological properties. natural actives Buddleja Davidii Stems G summer lilac uva-protection anti-oxidant anti-aging Skin regeneration Skin-care Sun-care Cosmetics DESCRIPTION Comprehensive approach on the 3 main mechanisms of photoaging: protection from UV-induced oxidative stress, inhibition of inflammation, control of UV-induced matrix metalloproteinase (MMP) activation ANTI-OXIDANT ACTIVITY Buddleja davidii stems has an antioxidant activity higher than other common natural antioxidant benchmarks. (See picture 1) * IC50: concentration of a substance required for reducing at 50% the DPPH free radical. ANTI-INFLAMMATORY ACTIVITY Verbascoside shows a strong antiinflammatory activity since it induces a dose-dependent decrease of the expression of the pro-inflammatory chemokine IL-8 on primary cultures of human keratinocytes stimulated by TNF-alpha. (See picture 2) ANTI-COLLAGENASIC ACTIVITY Thanks to the synergistic effect of its constituents, Buddleja davidii stems inhibits collagenase more efficaciously than purified verbascoside. (See picture 3) INCI & GENERAL COMPOSITION glycerine, buddleja davidii meristem cell culture, xanthan gum. Recommended Concentration: 0,5 – 5 % Formulation guidelines: compatible with O/W emulsions, serum, ... | pH ≤ 6 | introducing during the cooling phase APPEARANCE amber-coloured liquid Pesticides absent Microbiological Specifications bacteria < 100 UFC/g fungi < 100 UFC/g Packaging 1 Kg Storage Store the product in the original, well closed container, in a cool, dry area and protected from light Shelf life 12 months Cosmetic Uses boosting skin defence to oxidative stress protection from UVA-photodamage prevention of aging and photoaging effects prevention of post-inflammatory spots the Clinical Evidence 10 subjects 5 days daily treatment of a skin area with a O/W cream containing 2% of Buddleja davidii stems or the placebo fixed dose UVA irradiation (15 J/cm2) skin tape stripping and determination of lipid peroxides (LPO) and total antioxidant capacity (FRAP): before UVA irradiation 4 and 24 hours after the irradiation Buddleja davidii stems demonstrates to be a broad and highly effective protection against UVA-photodamage, even vs placebo: significant preservation of the lipid component of the skin from oxidative stress significant increase of the antioxidant resistance of the skin © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: glycerophosphoinositol chloline / lysine, phonoxyethanol, ethylhexylglycerin, aqua FUNCTION: against inflammation, dandruff solution, protection: chemical & physical agents, UVB DESCRIPTION: Glycerophosphoinositol (GPI) choline is an innovative sunflower lecithin-derived active ingredient, covered by a wide international patent both on the molecule and its cosmetic application. anti-dandruff after-sun anti-aging natural actives Glycerophosphoinositol Choline / Lysine (gpi) Skin regeneration anti-dandruff Skin-care Sun-care Hair-care Cosmetics DESCRIPTION Glycerophosphoinositol (GPI) salts are innovative sunflower lecithin derived active ingredients, covered by a wide international patent both on the molecules and their cosmetic application. They are semisyntetic derivates of glycerophosphoinositol, a natural cell component produced by lipid metabolism. GPI acts upstream in the inflammatory cascade via an innovative mechanism of action since it fits into an entirely physiological auto-regulating system. protection from physical agents GPI salts significantly suppress uvb-induced Prostaglandin E2 secretion in Normal Human Epidermal Keratinocytes. protection from chemical agents GPI salts inhibit the release of pro-inflammatory cytokine IL-1alpha from keratinocytes of 3d human epidermis system treated with sls surfactant agent. The compound alone does not cause a detectable cytokine release. INCI & GENERAL COMPOSITION aqua/water, glycerophosphoinositol choline, phonoxyethanol, ethylhexylglycerin respectively aqua/water, glycerophosphoinositol lysine, phonoxyethanol, ethylhexylglycerin Recommended Concentration: 1 – 10 % (corresponding to 0,1-1% GPI choline) Formulation guidelines: Compatible with any type of formulation (emulsions, lotions, shampoos, ...) pH 6,0 - 7,8 stable to wide temperature and pH ranges enhanced activity in association with phospholipids (eg. Lecithin) APPEARANCE GPI choline: opalescent liquid GPI lysine: opalescent light yellow liquid Preservatives 0,9% phenoxythanol, 0,1% ethylhexylglycerin Packaging 1 Kg Storage Store the product in the original closed container in a cool area Shelf life 36 months Cosmetic Uses after-sun and soothing treatments control of symptoms of sensitive and inflamed skin control of dandruff and related symptoms (redness, itch) prevention of photo-aging and aging (control of skin micro-inflammation) prevention of post-inflammatory spots the Clinical Evidence the skin: UVB-induced erythema (See picture 1) GPI choline has a lenitive activity comparable to that of a 0,1% cortisonic preparation (betamethasone valerate). 20 subjects, UVB irradiation of forearms (dosage: 2 MED), 6 hour application of topic formulations, 48 hour quantitative monitoring of erythema by reflectance spectrophotometry the scalp: the anti-dandruff activity (See picture 2) 10 patients suffering of seborrhoeic dermatitis and dandruff of the scalp. once a day treatment for 30 days with a 0,25% GPI choline lotion, clinical and dermathoscopical monitoring of symptoms at the end of treatment, GPI choline induces a marked and rapid reduction of dandruff and related symptoms such as itchiness and redness. © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller. INCI: centella asiatica meristem cell culture, glycerine, xanthan gum FUNCTION: deep firming activity to improve skin tone & elasticity DESCRIPTION: preparation of 20% of centella asiatica stem cells in plant glycerine, without preservatives anti-oxidant, anti-hyaluronidasic, anti-inflammatory / vasoactive effect natural actives Centella Asiatica Stems G tiger grass / asiatic pennywort / gotu kola natural skin-care Cosmetics 1 Trolox Rutin CQs-CA 0 0 ,25 0 ,5 0,75 1 1,25 1,5 1,75 TEAC units* 2 100 % hyaluronidase inhibition 90 80 70 60 50 40 30 20 10 0 0,2 100 % TNF-α inhibition production DESCRIPTION Centella asiatica, also known as Gotu Kola or Tiger Grass, is a small herbaceous plant of the family Apiaceae or Umbellifereae and is native to Southeast Asia, Australia, Madagascar and Africa. Centella grows in very wet and marshy areas, over 700 meters altitude, and being aquatic, it is especially sensitive to pollutants in the water, which are easily incorporated into the plant. It is used in Indian traditional medicine for the treatment of several diseases and in dermatology for the healing of wounds, burns and varicose ulcers. anti-oxidant activity Centella asiatica stems G is rich of substances with antioxidant activity higher than that of common natural antioxidant benchmarks. anti-hyaluronidasic activity Hyaluronic acid is a major constituent of the extracellular matrix of the dermis and it is responsible for skin hydration and elasticity. A decrease of hyaluronic acid, due to the enzyme hyaluronidase, produces loss of skin firmness. Thanks to the synergistic effect of its constituents, Centella asiatica stems G efficiently inhibits hyaluronidase up to 90%. anti-inflamm. activity / vasoactive effect Caffeoylquinic acids from Centella asiatica stems G exert a significant inhibition of the production of both TNF-alpha, a cytokine involved in the promotion of the inflammation, and nitric oxide (NO), a 0,5 1 2 4 3 CQs-CA 90 mg/mL rutin 80 70 60 50 40 30 20 10 0 0,1 0,2 0,4 0 ,8 mg/mL 60 50 inci 40 centella asiatica meristem cell culture, 30 glycerine, xanthan gum 20 10 cosmetic uses 0 firming body0 ,8treat- mg/mL 0,1and restructuring 0,2 0,4 ments support of anti-stretch mark treatments control of cellulite flaws support of treatments for blood vessel tone disorders recommended concentration 0,5 – 5 % formulation guidelines: Compatible with O/W emulsions, serum... pH ≤ 6 introducing during the cooling phase appearance yellow amber liquid Microbiological Specifications Total microbial count: bacteria < 100 UFC/g fungi < 100 UFC/g shelf life 24 months store the product in the original, well closed container, in a cool, dry area and protected from light 100 4 CQs-CA 90 % NO inhibition production % TNF-α inhibition production 100 signalling molecule which induces 3 blood CQs-CA 90 vessel relaxation. Centella asiatica stems rutin G80 is useful in the control of inflammation 70 and blood vessel tone and permeability. rutin 80 70 60 50 40 30 20 10 0 0,1 0,2 0,4 0 ,8 mg/m L HTN™ technology identification of specific substances with high biological activities whose cosmetic use has been patented. Mixture of caffeoylquinic acids (CQsCA) such as 3,5-dicaffeoylquinic acid, 1,3,5-tricaffeoylquinic acid: antioxidant, anti-inflammatory and skin lightening activity. Phytosterols, amino acides, polysaccharides: moisturizing and nutrients. Patent protection: patent application n. E08425406.9 © 2010 Mani GmbH | verantwortlich für Einzelwerte & deren Einhaltung ist der Hersteller.