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Bone marrow pathology in essential thrombocythemia: interobserver reliability and utility for identifying disease subtypes by Bridget S. Wilkins, Wendy N. Erber, David Bareford, Georgina Buck, Keith Wheatley, Clare L. East, Beverley Paul, Claire N. Harrison, Anthony R. Green, and Peter J. Campbell Blood Volume 111(1):60-70 January 1, 2008 ©2008 by American Society of Hematology Examples of morphologic features scored on 370 diagnostic bone marrow trephine specimens from patients enrolled in prospective clinical trials of ET. (A) H&E-stained section (×400 magnification) showing a large, staghorn megakaryocyte in the center of the f... Bridget S. Wilkins et al. Blood 2008;111:60-70 ©2008 by American Society of Hematology Trephine histology showing morphologic features that suggest different WHO diagnoses in the same medium- (×400) or high-power (×1000) field. Bridget S. Wilkins et al. Blood 2008;111:60-70 ©2008 by American Society of Hematology Subjective and objective predictors of WHO diagnosis. Bridget S. Wilkins et al. Blood 2008;111:60-70 ©2008 by American Society of Hematology Exploratory factor analysis identified 3 underlying processes contributing to the morphologic patterns of ET. Shown for each factor are the 5 variables that contribute most heavily to each factor, with the y-axis representing their relative weight (contribu... Bridget S. Wilkins et al. Blood 2008;111:60-70 ©2008 by American Society of Hematology A model for the myeloproliferative diseases. Bridget S. Wilkins et al. Blood 2008;111:60-70 ©2008 by American Society of Hematology
