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Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy by Andrea Z. Tuckett, Raymond H. Thornton, Yusuke Shono, Odette M. Smith, Emily R. Levy, Fabiana M. Kreines, Marcel R. M. van den Brink, and Johannes L. Zakrzewski Blood Volume 123(18):2797-2805 May 1, 2014 ©2014 by American Society of Hematology ITI of multipotent stem cells results in efficient T-cell generation in sublethally irradiated syngeneic recipients. Andrea Z. Tuckett et al. Blood 2014;123:2797-2805 ©2014 by American Society of Hematology Intrathymically injected HSPCs give rise to functional T cells. Andrea Z. Tuckett et al. Blood 2014;123:2797-2805 ©2014 by American Society of Hematology Intrathymically injected HSPCs contribute to T-cell reconstitution after BMT. (A) Lethally irradiated C57BL/6 recipients were transplanted with C57BL/6.CD45.1+ Lin− BM cells and received 3000 C57BL/6.Thy1.1+ luciferase-expressing LSK cells via ITI 2 hours a... Andrea Z. Tuckett et al. Blood 2014;123:2797-2805 ©2014 by American Society of Hematology ITI of multipotent HSPCs results in long-lasting generation of donor T cells. Andrea Z. Tuckett et al. Blood 2014;123:2797-2805 ©2014 by American Society of Hematology ITI of cells or drugs can rejuvenate and enhance thymopoiesis of aged recipients. Andrea Z. Tuckett et al. Blood 2014;123:2797-2805 ©2014 by American Society of Hematology ITI of HSPCs from Pmel-1 mice inhibits intradermal growth of melanoma cells. Andrea Z. Tuckett et al. Blood 2014;123:2797-2805 ©2014 by American Society of Hematology
