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Transcript
Membrane-bound protein C, protein S, thrombomodulin™, and endothelial cell protein C receptor (EPCR). Each protein is a multidomain protein that
extends above the surface of cell membranes, and different domains mediate different functions of each protein. Proteins C and S can bind reversibly to
phospholipid membranes through their NH2-terminal γ-carboxyglutamic acid (GLA) domains which contain 9 or 11 GLA residues that bind four to six Ca2+
ions. TM and EPCR are integral membrane proteins that are embedded in cell membranes by a single hydrophobic transmembrane sequence.
(Adapted with permission from Esmon CT.91)
Source: Chapter 116. Control of Coagulation Reactions, Williams Hematology, 8e
Citation: Lichtman MA, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT. Williams Hematology, 8e; 2010 Available at: http://mhmedical.com/
Accessed: June 10, 2017
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