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Transcript
Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo by Marioara F. Ciuculescu, Shin-Young Park, Kimberly Canty, Ronald Mathieu, Leslie E. Silberstein, and David A. Williams Blood Volume 125(20):3105-3113 May 14, 2015 ©2015 by American Society of Hematology Rac excision from perivascular niche leads to enhanced apoptosis and decreased numbers of Nestin+ cells and reduced homing of WT cells into the BM of perivascular Rac-deleted mice. Marioara F. Ciuculescu et al. Blood 2015;125:3105-3113 ©2015 by American Society of Hematology Rac deletion in Nestin+ cells disturbs the vascular morphology in the medullary cavity. Marioara F. Ciuculescu et al. Blood 2015;125:3105-3113 ©2015 by American Society of Hematology Deletion of Rac genes in perivascular space leads to abnormal trabecular bone formation in the medullary cavity. Marioara F. Ciuculescu et al. Blood 2015;125:3105-3113 ©2015 by American Society of Hematology Deletion of Rac genes in Nestin+ cells leads to alterations in osteoblasts populations. Marioara F. Ciuculescu et al. Blood 2015;125:3105-3113 ©2015 by American Society of Hematology Rac excision in Nestin+ cells is associated with decreased HSCs and progenitors. Marioara F. Ciuculescu et al. Blood 2015;125:3105-3113 ©2015 by American Society of Hematology
