Central Role of Voltage Gated Calcium Channels and
... functioning is of central importance in many aspects of embryonic and postnatal brain development, including neuronal gene expression and differentiation, growth, branching, migration, and structural organisation of developing neurons. Calcium influx through these channels is directly involved in se ...
... functioning is of central importance in many aspects of embryonic and postnatal brain development, including neuronal gene expression and differentiation, growth, branching, migration, and structural organisation of developing neurons. Calcium influx through these channels is directly involved in se ...
Excitation-contraction coupling in cardiomyocytes
... In a simplified manner the 3 muscle types can serve as models for the 3 major mechanisms of SR Ca-release (VDCR: skeletal muscle; CICR: cardiac muscle; IP3ICR: smooth muscle) This is an oversimpliplification since all 3 mechanism may be present and functional in all 3 muscle types. ...
... In a simplified manner the 3 muscle types can serve as models for the 3 major mechanisms of SR Ca-release (VDCR: skeletal muscle; CICR: cardiac muscle; IP3ICR: smooth muscle) This is an oversimpliplification since all 3 mechanism may be present and functional in all 3 muscle types. ...
Distinct and collaborative roles of Drosophila EXT family proteins in
... together, these results suggest that both botv and sotv are segment-polarity genes, and are likely to be involved in Hh and/or Wg signalling. botv and sotv encode the Drosophila homologues of mammalian EXTL3 and EXT2, respectively, and are required for HS GAG biosynthesis botv and sotv were subseque ...
... together, these results suggest that both botv and sotv are segment-polarity genes, and are likely to be involved in Hh and/or Wg signalling. botv and sotv encode the Drosophila homologues of mammalian EXTL3 and EXT2, respectively, and are required for HS GAG biosynthesis botv and sotv were subseque ...
Supplementary Data - Institute of Cancer Research
... heat-killed bacteria (Fig. 3b and Supplementary Fig. 3e). Therefore, we conclude that rLC contributes to the resolution of immune activation by sensing the presence of polymeric PGN from dead bacteria. Despite efficient bacterial clearance, rLC mutants died significantly earlier than wild-type contr ...
... heat-killed bacteria (Fig. 3b and Supplementary Fig. 3e). Therefore, we conclude that rLC contributes to the resolution of immune activation by sensing the presence of polymeric PGN from dead bacteria. Despite efficient bacterial clearance, rLC mutants died significantly earlier than wild-type contr ...
Molecular Characterization of the Melanin
... were constructed separately, then docked together as described in Materials and Methods. The receptor model contains two discrete hydrophilic pockets, one between transmembrane domains 3 and 7 and the other between transmembrane domains 4, 5, and 6, which are separated by a central hydrophobic regio ...
... were constructed separately, then docked together as described in Materials and Methods. The receptor model contains two discrete hydrophilic pockets, one between transmembrane domains 3 and 7 and the other between transmembrane domains 4, 5, and 6, which are separated by a central hydrophobic regio ...
doc
... ULG2 studies the scaffold protein TANK/I-TRAF, which is a TRAF2 and IKK-interacting protein that is required for the TNF-induced and NF-B-dependent expression of a selection of target genes (Bonif et al., 2006). The fact that TANK also binds TBK1 and IKK kinases, which are essential components of ...
... ULG2 studies the scaffold protein TANK/I-TRAF, which is a TRAF2 and IKK-interacting protein that is required for the TNF-induced and NF-B-dependent expression of a selection of target genes (Bonif et al., 2006). The fact that TANK also binds TBK1 and IKK kinases, which are essential components of ...
Abstract Panax ginseng Meyer, belonging to the genus Panax of the
... GP pretreatmentin vitro, which were increased in murine macrophages with the stimulation of S. aureus[33] and [39]. On the contrary, Friedl et al [16] and Lemmon et al [29] showed that American GP extracts may mediate the immunostimulatory effect by the inducible nitric oxide synthase (iNOS), mitoge ...
... GP pretreatmentin vitro, which were increased in murine macrophages with the stimulation of S. aureus[33] and [39]. On the contrary, Friedl et al [16] and Lemmon et al [29] showed that American GP extracts may mediate the immunostimulatory effect by the inducible nitric oxide synthase (iNOS), mitoge ...
THE ROLE OF PHOSPHODIESTERASES IN CYCLIC NUCLEOTIDE COMPARTMENTATION ACROSS DIFFERENT
... respective receptors with a heterotrimer (composed of α, β, and γ subunits). This results in a GTP-GDP exchange on the G α subunit, causing dissociation. This leaves either the Gα or Gβγ subunits to act on effector molecules, thereby regulating the generation of second messengers. Second messengers ...
... respective receptors with a heterotrimer (composed of α, β, and γ subunits). This results in a GTP-GDP exchange on the G α subunit, causing dissociation. This leaves either the Gα or Gβγ subunits to act on effector molecules, thereby regulating the generation of second messengers. Second messengers ...
Microsporidia: Why Make Nucleotides if You Can Steal Them?
... machinery for both RNA degradation pathways is present in microsporidia (S2 Fig) including the Ccr4 complex [4]; the decapping enzymes Dcp1 and Dcp2 [29]; the exonuclease Rat1, which is involved in 5’ to 3’ degradation; and the exosomal complex needed for 3’ to 5’ degradation, including the exosomal ...
... machinery for both RNA degradation pathways is present in microsporidia (S2 Fig) including the Ccr4 complex [4]; the decapping enzymes Dcp1 and Dcp2 [29]; the exonuclease Rat1, which is involved in 5’ to 3’ degradation; and the exosomal complex needed for 3’ to 5’ degradation, including the exosomal ...
Non-Quantal Acetylcholine Release at the Neuromuscular Junction
... research about the NQR that is undoubtedly an important trophic factor during endplate development and in adult neuromuscular contacts. NQR helps to eliminate the polyneural innervation of developing muscle fibers, ensures higher excitability of the adult subsynaptic membrane by surplus polarization ...
... research about the NQR that is undoubtedly an important trophic factor during endplate development and in adult neuromuscular contacts. NQR helps to eliminate the polyneural innervation of developing muscle fibers, ensures higher excitability of the adult subsynaptic membrane by surplus polarization ...
PhD értekezés tézisei
... Deconvolution into four components was performed by using PeakFit 4.0 software from SPSS Corporation. For analysis of the single thermal transitions Gaussian functions were assumed. The comparison between the DSC patterns different states of the fibre bundles suggested that the second and third Gaus ...
... Deconvolution into four components was performed by using PeakFit 4.0 software from SPSS Corporation. For analysis of the single thermal transitions Gaussian functions were assumed. The comparison between the DSC patterns different states of the fibre bundles suggested that the second and third Gaus ...
Microsporidia: Why Make Nucleotides if You Can Steal Them?
... machinery for both RNA degradation pathways is present in microsporidia (S2 Fig) including the Ccr4 complex [4]; the decapping enzymes Dcp1 and Dcp2 [29]; the exonuclease Rat1, which is involved in 5’ to 3’ degradation; and the exosomal complex needed for 3’ to 5’ degradation, including the exosomal ...
... machinery for both RNA degradation pathways is present in microsporidia (S2 Fig) including the Ccr4 complex [4]; the decapping enzymes Dcp1 and Dcp2 [29]; the exonuclease Rat1, which is involved in 5’ to 3’ degradation; and the exosomal complex needed for 3’ to 5’ degradation, including the exosomal ...
Growth factors and tooth development
... dental cell differentiation. Autoradiographic localization of proliferating cells revealed that dental tissues responded to EGF with different proliferation rates. The responsiveness to EGF was stage-dependent. early cap-staged teeth were sensitive to EGF but late cap-staged and bell-staged teeth de ...
... dental cell differentiation. Autoradiographic localization of proliferating cells revealed that dental tissues responded to EGF with different proliferation rates. The responsiveness to EGF was stage-dependent. early cap-staged teeth were sensitive to EGF but late cap-staged and bell-staged teeth de ...
PDF - Herbert Publications
... excellently demonstrated by P.B. Medawar and won both There are other unsolved questions. If our current views scientists the Nobel Prize. on the biological role of the immune system are correct, then To date, however, much more questions than answers have lymphocytes with specific receptors for all ...
... excellently demonstrated by P.B. Medawar and won both There are other unsolved questions. If our current views scientists the Nobel Prize. on the biological role of the immune system are correct, then To date, however, much more questions than answers have lymphocytes with specific receptors for all ...
Trafficking of the human transferrin receptor in plant cells: effects of
... Plant cells possess much of the molecular machinery necessary for receptor-mediated endocytosis (RME), but this process still awaits detailed characterization. In order to identify a reliable and well-characterized marker to investigate RME in plant cells, we have expressed the human transferrin rec ...
... Plant cells possess much of the molecular machinery necessary for receptor-mediated endocytosis (RME), but this process still awaits detailed characterization. In order to identify a reliable and well-characterized marker to investigate RME in plant cells, we have expressed the human transferrin rec ...
Glycolysis
... • Fructose-6-phosphate is an intermediate of glycolysis. • Fructose-1-phosphate is acted upon by an aldolase-like enz that gives DHAP and glyceraldehyde. • DHAP is a glycolysis intermediate and glyceraldehyde can be phosphorylated to glyceraldehyde-3-P. • Glycerol is phosphorylated to G-3-P which is ...
... • Fructose-6-phosphate is an intermediate of glycolysis. • Fructose-1-phosphate is acted upon by an aldolase-like enz that gives DHAP and glyceraldehyde. • DHAP is a glycolysis intermediate and glyceraldehyde can be phosphorylated to glyceraldehyde-3-P. • Glycerol is phosphorylated to G-3-P which is ...
Informatics approaches to understanding TGFb pathway regulation
... responses in target cells via a variety of pathways dictates that their activity is strictly regulated to avoid unintended consequences. Studies in many organisms have shown that negative regulation of the TGFb pathway can be accomplished by a variety of mechanisms. In an accompanying review article ...
... responses in target cells via a variety of pathways dictates that their activity is strictly regulated to avoid unintended consequences. Studies in many organisms have shown that negative regulation of the TGFb pathway can be accomplished by a variety of mechanisms. In an accompanying review article ...
Purinergic signalling
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions.The purinergic signalling complex of a cell is sometimes referred to as the “purinome”.