The Sympathetic Nerve—An Integrative Interface between Two
... the two major adaptive systems of the body. During an immune response the brain and the immune system “talk to each other” and this process is essential for maintaining homeostasis. Two major pathway systems are involved in this cross-talk: the hypothalamic-pituitary-adrenal (HPA) axis and the sympa ...
... the two major adaptive systems of the body. During an immune response the brain and the immune system “talk to each other” and this process is essential for maintaining homeostasis. Two major pathway systems are involved in this cross-talk: the hypothalamic-pituitary-adrenal (HPA) axis and the sympa ...
The Cell Adhesion Molecule Neuroplastin
... are the major inhibitory transmitter receptors in the central nervous system and the site of action of benzodiazepines, barbiturates, neurosteroids, anesthetics, and convulsants. They are ligand-gated ion channels composed of five subunits that can belong to different subunit classes, thus giving ri ...
... are the major inhibitory transmitter receptors in the central nervous system and the site of action of benzodiazepines, barbiturates, neurosteroids, anesthetics, and convulsants. They are ligand-gated ion channels composed of five subunits that can belong to different subunit classes, thus giving ri ...
Molecular factors underlying selective vulnerability of motor neurons
... mechanisms exist for particular classes of neurons, such as motor neurons, to express a unique molecular profile of ionotropic glutamate receptors, suited to cell-specific functional properties. Normal glutamate neurotransmission involves the vesicular release of glutamate into the synaptic cleft wh ...
... mechanisms exist for particular classes of neurons, such as motor neurons, to express a unique molecular profile of ionotropic glutamate receptors, suited to cell-specific functional properties. Normal glutamate neurotransmission involves the vesicular release of glutamate into the synaptic cleft wh ...
TESI DOCTORAL NEUROKININ-1 RECEPTOR: STRATEGIES OF EXPRESSION, PURIFICATION AND REFOLDING
... and external environments of cells. All of GPCRs present very similar mechanism of activation initiated by binding of a ligand which activates specific heterotrimeric proteins, leading to the modulation of downstream effector proteins (figure 1.3). As an example, in human β2-adrenergic receptor, the ...
... and external environments of cells. All of GPCRs present very similar mechanism of activation initiated by binding of a ligand which activates specific heterotrimeric proteins, leading to the modulation of downstream effector proteins (figure 1.3). As an example, in human β2-adrenergic receptor, the ...
- The Pawson Lab
... activity; juxtamembrane sites of tyrosine phosphorylation and SH2 domain-binding were required for cell dissociation, but not for posterior protrusions. The induction of protrusions and expansion of posterior structures is similar to phenotypic effects observed in Xenopus embryos expressing activate ...
... activity; juxtamembrane sites of tyrosine phosphorylation and SH2 domain-binding were required for cell dissociation, but not for posterior protrusions. The induction of protrusions and expansion of posterior structures is similar to phenotypic effects observed in Xenopus embryos expressing activate ...
Calcium homeostasis
... Vitamin-D as the regulatory factor of calcium homeostasis • Vitamin-D increases calcium intake from intestine, bones and kidneys • Calcitriol is a vitamin d metabolite that upregulates calcium binding protein expression causing uptake of calcium • Kidneys observe calcium level in blood and produce ...
... Vitamin-D as the regulatory factor of calcium homeostasis • Vitamin-D increases calcium intake from intestine, bones and kidneys • Calcitriol is a vitamin d metabolite that upregulates calcium binding protein expression causing uptake of calcium • Kidneys observe calcium level in blood and produce ...
Relationship between neurotransmitter release and cytosolic free
... It is generally assumed that the release of most if not all neurotransmitters occurs via exocytosis. A major established concept is that secretory exocytosis in nerve terminals, as well as in other cell types, is initiated when the concentration of Cat+ is increased in cytoplasm above some threshold ...
... It is generally assumed that the release of most if not all neurotransmitters occurs via exocytosis. A major established concept is that secretory exocytosis in nerve terminals, as well as in other cell types, is initiated when the concentration of Cat+ is increased in cytoplasm above some threshold ...
Specific vasopressin binding to rat adrenal glomerulosa cells
... To test the stability of [3H]vasopressin during the course of the binding assay, glomerulosa cells were incubated for 15 min in the presence of [3H]vasopressin (5 nM). A small sample of the culture medium was collected at the end of the incubation period and submitted to h.p.l.c. analysis. The eluti ...
... To test the stability of [3H]vasopressin during the course of the binding assay, glomerulosa cells were incubated for 15 min in the presence of [3H]vasopressin (5 nM). A small sample of the culture medium was collected at the end of the incubation period and submitted to h.p.l.c. analysis. The eluti ...
Structural Studies of Human 5’-Nucleotidases Karin Walldén
... enzymes, which are the catalysts of life. Humans contain thousands of different enzymes that catalyze specific chemical reactions. Some enzymes degrade components of food and channel the energy released by this process into chemical energy in the form of for instance the nucleotide ATP. Other enzyme ...
... enzymes, which are the catalysts of life. Humans contain thousands of different enzymes that catalyze specific chemical reactions. Some enzymes degrade components of food and channel the energy released by this process into chemical energy in the form of for instance the nucleotide ATP. Other enzyme ...
Studies of Energy-Yielding Reactions in Thymus Nuclei. 1
... adenosine triphosphate, i.e. in nonapueous media. In 1957, Osawa et al. (7) showed that thymus nuclei isolated in 0.25 M sucrose-O.003 M CaClt can cause a net synthesis of adenosine triphosphate by an aerobic process that differs from oxidative phosphorylation in mitochondria in its insensitivity to ...
... adenosine triphosphate, i.e. in nonapueous media. In 1957, Osawa et al. (7) showed that thymus nuclei isolated in 0.25 M sucrose-O.003 M CaClt can cause a net synthesis of adenosine triphosphate by an aerobic process that differs from oxidative phosphorylation in mitochondria in its insensitivity to ...
Cholesterol and bile acids regulate xenosensor signaling in
... Cytochromes P450 (CYPs)1 are heme-containing enzymes responsible for the hydroxylation of lipophilic substrates in all species. In the liver, a subset of members of the CYP gene superfamily metabolize xenobiotics such as drugs, food additives and pollutants (1). Some of these CYPs can be transcripti ...
... Cytochromes P450 (CYPs)1 are heme-containing enzymes responsible for the hydroxylation of lipophilic substrates in all species. In the liver, a subset of members of the CYP gene superfamily metabolize xenobiotics such as drugs, food additives and pollutants (1). Some of these CYPs can be transcripti ...
VEGF exists in different isoforms
... 1) Long-range signalling molecule 2) Acts directly on cells ...
... 1) Long-range signalling molecule 2) Acts directly on cells ...
USING ADENOSINE TRIPHOSPHATE (ATP) AS A SUBSTITUTE APPLICATIONS
... Osteoarthritis is the end result of damage to articular cartilage, which lacks the ability to self-repair. Tissue engineering of cartilage is a promising field of study that aims to promote healing of cartilage in vivo by manipulation of the chondrocytes that maintain the tissue, or through in vitro ...
... Osteoarthritis is the end result of damage to articular cartilage, which lacks the ability to self-repair. Tissue engineering of cartilage is a promising field of study that aims to promote healing of cartilage in vivo by manipulation of the chondrocytes that maintain the tissue, or through in vitro ...
Increased and controlled expression of the Rickettsia
... Medicine, Mobile, AL) and purified using the MERmaid Kit (BiolOl) according to the manufacturer's instructions. HW1 was used to convert the codon for Cys37 to a codon specifying ...
... Medicine, Mobile, AL) and purified using the MERmaid Kit (BiolOl) according to the manufacturer's instructions. HW1 was used to convert the codon for Cys37 to a codon specifying ...
Potassium regulation
... • Increased distal tubular flow / - salt wasting nephropathies - osmotic diuretcs - loop diuretics • Excess aldosterone or other mineralocorticoids ...
... • Increased distal tubular flow / - salt wasting nephropathies - osmotic diuretcs - loop diuretics • Excess aldosterone or other mineralocorticoids ...
mpges
... mPGES-1 has been found to be localized in synovial lining cells, mononuclear and fibroblast-like cells present in the sublining, infiltrating synovial macrophages and vascular endothelial cells. Moreover, mPGES-1 expression was upregulated in synovium selectively in active RA and was minimally expre ...
... mPGES-1 has been found to be localized in synovial lining cells, mononuclear and fibroblast-like cells present in the sublining, infiltrating synovial macrophages and vascular endothelial cells. Moreover, mPGES-1 expression was upregulated in synovium selectively in active RA and was minimally expre ...
Purinergic signalling
Purinergic signalling (or signaling: see American and British English differences) is a form of extracellular signalling mediated by purine nucleotides and nucleosides such as adenosine and ATP. It involves the activation of purinergic receptors in the cell and/or in nearby cells, thereby regulating cellular functions.The purinergic signalling complex of a cell is sometimes referred to as the “purinome”.