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المملكة العربية السعودية وزارة التعليم العالي جامعة سلمان بن عبدالعزيز كلية العلوم الطبية التطبيقية وادي الدواسر Kingdom of Saudi Arabia Ministry of Higher Education Salman Bin Abdulaziz University College of Applied Medical Science Wadi Addawasir Medical Lab Sciences Department Second Midterm Exam nd 2 Semester, Level-5, 1433/1434 H Student name: ...................................... Student number: ................................. Day/Date: Saturday, 17/06/1434 H Course Title: Clinical chemistry-I Course code and number: MLAB-353 Section-47 Total marks: 30/3=10 Time: 2 hours ____________________________________________________________________________________________ Student marks Section No. Marks 1 2 3 4 5 10 6 ______ Total 30 Name of teacher Corrected by Signature Dr. Kakul Husain Reviewed by 1 Dr. Kakul Husain المملكة العربية السعودية وزارة التعليم العالي جامعة سلمان بن عبدالعزيز كلية العلوم الطبية التطبيقية وادي الدواسر Kingdom of Saudi Arabia Ministry of Higher Education Salman Bin Abdulaziz University College of Applied Medical Science Wadi Addawasir Medical Lab Sciences Department Second Midterm Exam nd 2 Semester, Level-5, 1433/1434 H Student Name: ...................................... Day/Date: Saturday, 17/06/1434 H Course Title: Clinical Chemistry-I Student Number: ................................. Time: 2 hours ______________________________________________________________________________________ Answer all the following questions: [1] Choose the correct answer:- [10X½= 5 Marks] 1. The best temperature at which the enzyme work is called the ………….temperature. a. right b. low c. optimum d. high 2. Each triplet of nucleotides, called a codon, specifies ……………..amino acid. a. one b. two c. three d. four 3. Any factor that directly affects the rate of a chemical reaction when its quantity is changed is called a ……………… a. denaturation b. limiting factor c. enzyme d. inhibitor 2 Dr. Kakul Husain 4. ………………………….. contains a nucleotide group. a. Vitamin A b. Vitamin B6 c. Vitamin C d. Vitamin E 5. The oldest known enzyme reaction is ……………………….. a. enzyme denaturation b. alcoholic fermentation c. for regulation functions d. none of the above 6. Which one of the following is the symbol for thyroxine………………… a. T4 b. T3 c. T5 d. T2 7. Which one of the following is lipid soluble hormone………………… a. steroid b. polypeptide c. amines d. all of the above 8. Epinephrine binds to receptors on the plasma membrane of …………...cells a. kidney b. intestinal c. liver d. pancreatic 3 Dr. Kakul Husain 9. The ………………gland, located in the brain, secretes melatonin. a. thyroid b. parathyroid c. adrenal d. pineal 10. Which one of the followings is a type of secreted signaling molecules. a. neurohormones b. enzyme c. liver cells d. DNA [2] Fill in the blanks from the following table: milk leukemia [6X1=6 Marks] optimum adrenal ------- gigantism negative hypothalamus 1) L-asparaginase is believed to be a potent weapon for treating leukemia. 2) An excess of GH can cause gigantism, while a lack of GH can cause dwarfism. 3) Oxytocin induces uterine contractions and the release of milk. 4) The adrenal glands are on the top of kidneys. 5) Negative feedback and antagonistic hormone pairs are common features of the endocrine system. 6) The hypothalamus receives information from the nervous system and initiates responses through the endocrine system. 4 Dr. Kakul Husain [3] Put true ‘T’ or false ‘F’ for the following statements: - [8X½= 4 Marks] F 1) At very high temperatures, the enzyme is active. F 2) Hormones are molecules that prevent enzymes reaching their maximum turnover numbers. F 1) Enzymes are changed at the end of the chemical reaction and cannot be reused. T 2) Endocrine gland secretes hormones into extracellular fluids and travel via the bloodstream. T 3) Vitamin Co-Factor amplifies the enzymes activity & stability. F 4) Androgens, most importantly testosterone, is responsible for maintenance of female reproductive system. T 5) Glucocorticoids, such as cortisol, influence glucose metabolism and the immune system. F 6) Paracrine signals act on the secreting cell itself. F 7) F 8) Hyperthyroidism is low secretion of thyroid hormones which causes weight gain, lethargy, and intolerance to cold. B and E vitamins are essential components of many coenzymes. 5 Dr. Kakul Husain [5]. Write short notes on any three [03] of the followings:- [3X2 =6 Marks] When the enzyme is denatured, then: the shape is changed the three-dimensional structure of the enzyme is lost the active site is altered. The four strictly tropic hormones are: Thyroid –stimulating hormone (TSH) Follicle-stimulating hormone (FSH) Luteinizing hormone (LH) Adrenocorticotropic hormone (ACTH) Glucagon increases blood glucose levels by: Stimulating conversion of glycogen to glucose in the liver. Stimulating breakdown of fat and protein into glucose. Genetic code: The rules by which the nucleotide sequence of a gene is translated into the amino acid sequence of a protein, the so-called genetic code. [6]. Differentiate between the two system-coordinates communication throughout the body: S. No. [1X3=3Marks] The endocrine system The nervous system 1. Slow speed high-speed electrical signals 2. Longer acting responses. Short term 3. Secretes hormones regulate all other cells 6 Dr. Kakul Husain [5(c)]. Draw the lock and key analogy for the enzyme –substrate action: [1X1 =1Marks] ***GOOD LUCK*** 7 Dr. Kakul Husain