Download Kingdom of Saudi Arabia Ministry of Higher Education Salman Bin

‫المملكة العربية السعودية‬
‫وزارة التعليم العالي‬
‫جامعة سلمان بن عبدالعزيز‬
‫كلية العلوم الطبية التطبيقية‬
‫وادي الدواسر‬
Kingdom of Saudi Arabia
Ministry of Higher Education
Salman Bin Abdulaziz University
College of Applied Medical Science
Wadi Addawasir
Medical Lab Sciences Department
Second Midterm Exam
nd
2 Semester, Level-5, 1433/1434 H
Student name: ......................................
Student number: .................................
Day/Date: Saturday, 17/06/1434 H
Course Title: Clinical chemistry-I
Course code and number: MLAB-353
Section-47
Total marks: 30/3=10
Time: 2 hours
____________________________________________________________________________________________
Student marks
Section No.
Marks
1
2
3
4
5
10
6
______
Total
30
Name of teacher
Corrected by
Signature
Dr. Kakul Husain
Reviewed by
1
Dr. Kakul Husain
‫المملكة العربية السعودية‬
‫وزارة التعليم العالي‬
‫جامعة سلمان بن عبدالعزيز‬
‫كلية العلوم الطبية التطبيقية‬
‫وادي الدواسر‬
Kingdom of Saudi Arabia
Ministry of Higher Education
Salman Bin Abdulaziz University
College of Applied Medical Science
Wadi Addawasir
Medical Lab Sciences Department
Second Midterm Exam
nd
2 Semester, Level-5, 1433/1434 H
Student Name: ......................................
Day/Date: Saturday, 17/06/1434 H
Course Title: Clinical Chemistry-I
Student Number: .................................
Time: 2 hours
______________________________________________________________________________________
Answer all the following questions:
[1] Choose the correct answer:-
[10X½= 5 Marks]
1. The best temperature at which the enzyme work is called the ………….temperature.
a. right
b. low
c. optimum
d. high
2. Each triplet of nucleotides, called a codon, specifies ……………..amino acid.
a. one
b. two
c. three
d. four
3. Any factor that directly affects the rate of a chemical reaction when its quantity is
changed is called a ………………
a. denaturation
b. limiting factor
c. enzyme
d. inhibitor
2
Dr. Kakul Husain
4. ………………………….. contains a nucleotide group.
a. Vitamin A
b. Vitamin B6
c. Vitamin C
d. Vitamin E
5. The oldest known enzyme reaction is ………………………..
a. enzyme denaturation
b. alcoholic fermentation
c. for regulation functions
d. none of the above
6. Which one of the following is the symbol for thyroxine…………………
a. T4
b. T3
c. T5
d. T2
7. Which one of the following is lipid soluble hormone…………………
a. steroid
b. polypeptide
c. amines
d. all of the above
8. Epinephrine binds to receptors on the plasma membrane of …………...cells
a. kidney
b. intestinal
c. liver
d. pancreatic
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Dr. Kakul Husain
9. The ………………gland, located in the brain, secretes melatonin.
a. thyroid
b. parathyroid
c. adrenal
d. pineal
10. Which one of the followings is a type of secreted signaling molecules.
a. neurohormones
b. enzyme
c. liver cells
d. DNA
[2] Fill in the blanks from the following table: milk
leukemia
[6X1=6 Marks]
optimum
adrenal
-------
gigantism
negative
hypothalamus
1) L-asparaginase is believed to be a potent weapon for treating leukemia.
2) An excess of GH can cause gigantism, while a lack of GH can cause dwarfism.
3) Oxytocin induces uterine contractions and the release of milk.
4) The adrenal glands are on the top of kidneys.
5) Negative feedback and antagonistic hormone pairs are common features of the endocrine
system.
6) The hypothalamus receives information from the nervous system and initiates responses
through the endocrine system.
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Dr. Kakul Husain
[3] Put true ‘T’ or false ‘F’ for the following statements: -
[8X½= 4 Marks]
F
1) At very high temperatures, the enzyme is active.
F
2) Hormones are molecules that prevent enzymes reaching their maximum
turnover numbers.
F
1) Enzymes are changed at the end of the chemical reaction and cannot be
reused.
T
2) Endocrine gland secretes hormones into extracellular fluids and travel
via the bloodstream.
T
3) Vitamin Co-Factor amplifies the enzymes activity & stability.
F
4) Androgens, most importantly testosterone, is responsible for
maintenance of female reproductive system.
T
5) Glucocorticoids, such as cortisol, influence glucose metabolism and the
immune system.
F
6) Paracrine signals act on the secreting cell itself.
F
7)
F
8) Hyperthyroidism is low secretion of thyroid hormones which causes
weight gain, lethargy, and intolerance to cold.
B and E vitamins are essential components of many coenzymes.
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Dr. Kakul Husain
[5]. Write short notes on any three [03] of the followings:-
[3X2 =6 Marks]
 When the enzyme is denatured, then:


the shape is changed
the three-dimensional structure of the enzyme is lost
the active site is altered.
 The four strictly tropic hormones are:





Thyroid –stimulating hormone (TSH)
Follicle-stimulating hormone (FSH)
Luteinizing hormone (LH)
Adrenocorticotropic hormone (ACTH)
Glucagon increases blood glucose levels by:

Stimulating conversion of glycogen to glucose in the liver.
Stimulating breakdown of fat and protein into glucose.
 Genetic code:
The rules by which the nucleotide sequence of a gene is translated into the amino
acid sequence of a protein, the so-called genetic code.
[6].
Differentiate between the two system-coordinates communication
throughout the body:
S. No.
[1X3=3Marks]
The endocrine system
The nervous system
1.
Slow speed
high-speed electrical signals
2.
Longer acting responses.
Short term
3.
Secretes hormones
regulate all other cells
6
Dr. Kakul Husain
[5(c)]. Draw the lock and key analogy for the enzyme –substrate action:
[1X1 =1Marks]
***GOOD LUCK***
7
Dr. Kakul Husain