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Pharynx • Oropharynx and laryngopharynx • Allow passage of food, fluids, and air • Skeletal muscle layers: inner longitudinal, outer pharyngeal constrictors Copyright © 2010 Pearson Education, Inc. Esophagus • Flat muscular tube from laryngopharynx to stomach • Travels through the diaphragm via an opening called the esophageal hiatus • Joins stomach at the cardiac orifice Copyright © 2010 Pearson Education, Inc. Esophagus • Esophageal glands secrete mucus to lubricate and aid in bolus movement • Muscularis: consists of skeletal muscle superiorly; smooth muscle inferiorly • Contains upper and lower esophageal sphincters: upper and lower that act as “gateways” for food • Lower esophageal sphincter prevents backflow of stomach contents into the esophagus Copyright © 2010 Pearson Education, Inc. (a) Copyright © 2010 Pearson Education, Inc. Mucosa (contains a stratified squamous epithelium) Submucosa (areolar connective tissue) Lumen Muscularis externa • Longitudinal layer • Circular layer Adventitia (fibrous connective tissue) Figure 23.12a Digestive Processes: Mouth • Ingestion • Mechanical digestion • Mastication is partly voluntary, partly reflexive • Chemical digestion (salivary amylase and lingual lipase) • Propulsion • Deglutition (swallowing) Copyright © 2010 Pearson Education, Inc. Deglutition – 2 major phases • Involves the tongue, soft palate, pharynx, esophagus, and 22 muscle groups • Buccal (oral) phase • Voluntary contraction of the tongue • Pharyngeal-esophageal phase • Involuntary (sensory receptors initiate the swallowing reflex) • Control center in the medulla and lower pons Copyright © 2010 Pearson Education, Inc. Bolus of food Tongue Pharynx Epiglottis Glottis Trachea 1 Upper esophageal sphincter is contracted. During the buccal phase, the tongue presses against the hard palate, forcing the food bolus into the oropharynx where the involuntary phase begins. Copyright © 2010 Pearson Education, Inc. Figure 23.13, step 1 Uvula Bolus Epiglottis Esophagus 2 The uvula and larynx rise to prevent food from entering respiratory passageways. The tongue blocks off the mouth. The upper esophageal sphincter relaxes, allowing food to enter the esophagus. Copyright © 2010 Pearson Education, Inc. Figure 23.13, step 2 Bolus 3 The constrictor muscles of the pharynx contract, forcing food into the esophagus inferiorly. The upper esophageal sphincter contracts (closes) after entry. Copyright © 2010 Pearson Education, Inc. Figure 23.13, step 3 Relaxed muscles Circular muscles contract 4 Food is moved through the esophagus to the stomach by peristalsis. Bolus of food Longitudinal muscles contract Gastroesophageal sphincter closed Stomach Copyright © 2010 Pearson Education, Inc. Figure 23.13, step 4 Relaxed muscles 5 The gastroesophageal sphincter opens, and food enters the stomach. Gastroesophageal sphincter opens Copyright © 2010 Pearson Education, Inc. Figure 23.13, step 5 Bolus of food Tongue Uvula Pharynx Bolus Epiglottis Epiglottis Glottis Trachea Bolus Esophagus 1 Upper esophageal sphincter is contracted. During the buccal phase, the tongue presses against the hard palate, forcing the food bolus into the oropharynx where the involuntary phase begins. Relaxed muscles 2 The uvula and larynx rise to prevent food from entering respiratory passageways. The tongue blocks off the mouth. The upper esophageal sphincter relaxes, allowing food to enter the esophagus. 4 Food is moved through the esophagus to the stomach by peristalsis. Circular muscles contract Bolus of food 3 The constrictor muscles of the pharynx contract, forcing food into the esophagus inferiorly. The upper esophageal sphincter contracts (closes) after entry. Relaxed muscles 5 The gastroesophageal sphincter opens, and food enters the stomach. Longitudinal muscles contract Gastroesophageal sphincter closed Gastroesophageal sphincter opens Stomach Copyright © 2010 Pearson Education, Inc. Figure 23.13 The Stomach Four Main Functions: 1. Temporary storage for ingested food 2. Mechanical breakdown of food 3. Chemical breakdown of food 4. Production of intrinsic factor, necessary for absorption of vitamin B12 Copyright © 2010 Pearson Education, Inc. Stomach: Gross Anatomy • Cardiac region (cardia) • Surrounds the cardiac orifice • Fundus • Dome-shaped region beneath the diaphragm • Body • Midportion Copyright © 2010 Pearson Education, Inc. Stomach: Gross Anatomy • Pyloric region: antrum, pyloric canal, and pylorus • Pylorus is continuous with the duodenum through the pyloric valve (sphincter) • Greater curvature • Convex lateral surface • Lesser curvature • Concave medial surface Copyright © 2010 Pearson Education, Inc. Cardia Esophagus Muscularis externa • Longitudinal layer • Circular layer • Oblique layer Lesser curvature Fundus Serosa Body Lumen Rugae of mucosa Greater curvature Duodenum (a) Copyright © 2010 Pearson Education, Inc. Pyloric Pyloric canal antrum Pyloric sphincter (valve) at pylorus Figure 23.14a Stomach: Gross Anatomy • Lesser omentum • From the liver to the lesser curvature • Greater omentum • Drapes from greater curvature • Anterior to the small intestine • Protects abdominal viscera Copyright © 2010 Pearson Education, Inc. Falciform ligament Liver Gallbladder Spleen Stomach Ligamentum teres Greater omentum Small intestine Cecum (a) Copyright © 2010 Pearson Education, Inc. Figure 23.30a Liver Gallbladder Lesser omentum Stomach Duodenum Transverse colon Small intestine Cecum Urinary bladder Copyright © 2010 Pearson Education, Inc. (b) Figure 23.30b Stomach: Microscopic Anatomy • Still has four tunics • Muscularis and mucosa are modified • Muscularis externa • Three layers of smooth muscle • Inner oblique layer allows stomach to churn, mix, move, and physically break down food Copyright © 2010 Pearson Education, Inc. 3 muscular layers •Longitudinal •Circular •Oblique Copyright © 2010 Pearson Education, Inc. Figure 23.15a Stomach: Microscopic Anatomy • Mucosa • Simple columnar epithelium composed of mucous cells • Produce a layer of mucus that traps bicarbonate-rich fluid beneath it • Protects the epithelial cells from acids, enzymes and abrasive materials • Gastric pits lead into gastric glands Copyright © 2010 Pearson Education, Inc. Gastric pits Surface epithelium (mucous cells) Gastric pit Mucous neck cells Parietal cell Chief cell Gastric gland Enteroendocrine cell (b) Enlarged view of gastric pits and gastric glands Copyright © 2010 Pearson Education, Inc. Figure 23.15b Gastric Glands • Cell types • Mucous neck cells (secrete thin, acidic mucus) • Parietal cells • Chief cells • Enteroendocrine cells Copyright © 2010 Pearson Education, Inc. Pepsinogen HCl Pepsin Mitochondria Parietal cell Chief cell Enteroendocrine cell (c) Location of the HCl-producing parietal cells and pepsin-secreting chief cells in a gastric gland Copyright © 2010 Pearson Education, Inc. Figure 23.15c Gastric Gland Secretions • Glands in the fundus and body produce most of the gastric juice Parietal cell secretions • HCl • pH 1.5–3.5 denatures protein in food, activates pepsin, and kills many bacteria • Intrinsic factor • Glycoprotein required for absorption of vitamin B12 in small intestine Copyright © 2010 Pearson Education, Inc. Gastric Gland Secretions • Chief cell secretions • Inactive enzyme pepsinogen • Converted to pepsin by HCl and by pepsin itself Copyright © 2010 Pearson Education, Inc. Homeostatic Imbalance • Gastritis: inflammation caused by anything that breaches the mucosal barrier • Peptic or gastric ulcers: erosion of the stomach wall • Most are caused by Helicobacter pylori bacteria • Cause 80% of gastric ulcers • Treated successfully with antibiotics Copyright © 2010 Pearson Education, Inc. Bacteria Mucosa layer of stomach (a) A gastric ulcer lesion Copyright © 2010 Pearson Education, Inc. (b) H. pylori bacteria Figure 23.16 Digestive Processes in the Stomach • Physical digestion • Denaturation (breakdown) of proteins • Enzymatic digestion of proteins by pepsin (and rennin in infants) • Secretion of intrinsic factor required for absorption of vitamin B12 • Lack of intrinsic factor pernicious anemia • Delivers chyme to the small intestine Copyright © 2010 Pearson Education, Inc. Regulation of Gastric Secretion • Regulated by CNS and hormonal mechanisms • Events occur in three phases: 1. Cephalic (reflex) phase: few minutes before food entry: • sight, smell, taste or thought of food initiates gastric secretion • Prepares the stomach to receive food Copyright © 2010 Pearson Education, Inc. Regulation of Gastric Secretion 2. Gastric phase: lasts for 3–4 hours after food enters the stomach (distending stomach) • Stimulates stretch receptors • Gastrin is released increasing gastric secretion production • Distension and gastrin increase force of contraction 3. Intestinal phase: brief stimulatory effect as partially digested food enters the duodenum, followed by inhibitory effects to slow gastric activity down giving the intestine time to do its job Copyright © 2010 Pearson Education, Inc. Pyloric valve closed 1 Propulsion: Peristaltic waves move from the fundus toward the pylorus. Copyright © 2010 Pearson Education, Inc. Pyloric valve closed 2 Grinding: The most vigorous peristalsis and mixing action occur close to the pylorus. Pyloric valve slightly opened 3 Retropulsion: The pyloric end of the stomach acts as a pump that delivers small amounts of chyme into the duodenum, simultaneously forcing most of its contained material backward into the stomach. Figure 23.19 Regulation of Gastric Emptying • As chyme enters the duodenum in 3 ml spurts • Receptors respond to stretch and chemical signals • Enterogastric reflex and enterogastrones inhibit gastric secretion and duodenal filling • Carbohydrate-rich chyme moves quickly through the duodenum • Fatty chyme remains in the duodenum 6 hours or more Copyright © 2010 Pearson Education, Inc. Small Intestine: Gross Anatomy • Major organ of digestion and absorption • 2–4 m (7-13 ft) long; from pyloric sphincter to ileocecal valve • Three Subdivisions 1. Duodenum – contains the bile duct and main pancreatic duct 2. Jejunum 3. Ileum Copyright © 2010 Pearson Education, Inc. Mouth (oral cavity) Tongue Esophagus Liver Gallbladder Duodenum Jejunum Small intestine Ileum Anus Copyright © 2010 Pearson Education, Inc. Parotid gland Sublingual gland Salivary Submandibular glands gland Pharynx Stomach Pancreas (Spleen) Transverse colon Descending colon Ascending colon Large Cecum intestine Sigmoid colon Rectum Vermiform appendix Anal canal Figure 23.1 Right and left hepatic ducts of liver Cystic duct Common hepatic duct Bile duct and sphincter Accessory pancreatic duct Mucosa with folds Gallbladder Major duodenal papilla Hepatopancreatic ampulla and sphincter Copyright © 2010 Pearson Education, Inc. Tail of pancreas Pancreas Jejunum Duodenum Main pancreatic duct and sphincter Head of pancreas Figure 23.21 Structural Modifications • Increase surface area of proximal part for nutrient absorption • Circular folds (plicae circulares) • Villi • Microvilli • Circular folds • Permanent ridged • Force chyme to slowly spiral through lumen Copyright © 2010 Pearson Education, Inc. Vein carrying blood to hepatic portal vessel Muscle layers Circular folds Villi Lumen (a) Copyright © 2010 Pearson Education, Inc. Figure 23.22a Structural Modifications • Villi • Motile fingerlike extensions of the mucosa • Villus epithelium • Simple columnar absorptive cells (enterocytes) • Goblet cells Copyright © 2010 Pearson Education, Inc. Structural Modifications • Microvilli • Projections (brush border) of absorptive cells • Contain brush border enzymes which complete carbohydrate and protein digestion in the small intestine Copyright © 2010 Pearson Education, Inc. Microvilli (brush border) Absorptive cells Lacteal Goblet cell Blood capillaries Mucosa associated lymphoid tissue Intestinal crypt Muscularis mucosae Duodenal gland (b) Copyright © 2010 Pearson Education, Inc. Vilus Enteroendocrine cells Venule Lymphatic vessel Submucosa Figure 23.22b Intestinal Juice • Secreted in response to distension or irritation of the mucosa • Slightly alkaline and isotonic with blood plasma • Largely water, enzyme-poor, but contains mucus • Facilitates transport and absorption of nutrients Copyright © 2010 Pearson Education, Inc. Liver • Largest gland in the body • Four lobes—right, left, caudate, and quadrate Copyright © 2010 Pearson Education, Inc. Liver • Falciform ligament • Separates the (larger) right and (smaller) left lobes • Suspends liver from the diaphragm and anterior abdominal wall • Round ligament (ligamentum teres) • Remnant of fetal umbilical vein along free edge of falciform ligament Copyright © 2010 Pearson Education, Inc. Sternum Nipple Liver Bare area Falciform ligament Left lobe of liver Right lobe of liver Gallbladder (a) Copyright © 2010 Pearson Education, Inc. Round ligament (ligamentum teres) Figure 23.24a Sternum Nipple Liver Lesser omentum (in fissure) Left lobe of liver Porta hepatis containing hepatic artery (left) and hepatic portal vein (right) Quadrate lobe of liver Ligamentum teres Bare area Caudate lobe of liver Sulcus for inferior vena cava Hepatic vein (cut) Bile duct (cut) Right lobe of liver Gallbladder (b) Copyright © 2010 Pearson Education, Inc. Figure 23.24b Liver: Associated Structures • Lesser omentum anchors liver to stomach • Hepatic artery and hepatic portal vein • Bile ducts • Common hepatic duct leaves the liver • Cystic duct connects to gallbladder • Bile duct formed by the union of the above two ducts Copyright © 2010 Pearson Education, Inc. Right and left hepatic ducts of liver Cystic duct Common hepatic duct Bile duct and sphincter Accessory pancreatic duct Mucosa with folds Gallbladder Major duodenal papilla Hepatopancreatic ampulla and sphincter Copyright © 2010 Pearson Education, Inc. Tail of pancreas Pancreas Jejunum Duodenum Main pancreatic duct and sphincter Head of pancreas Figure 23.21 Liver: Microscopic Anatomy • Liver lobules • Hexagonal structural and functional units • Filter and process blood • Composed of hepatocytes (liver cells) • Longitudinal central vein Copyright © 2010 Pearson Education, Inc. (a) Lobule Copyright © 2010 Pearson Education, Inc. (b) Central vein Connective tissue septum Figure 23.25a, b Liver: Microscopic Anatomy • Portal triad at each corner of lobule • Bile duct receives bile from bile canaliculi • Portal arteriole is a branch of the hepatic artery • Hepatic venule is a branch of the hepatic portal vein • Liver sinusoids are leaky capillaries between hepatic plates • Kupffer cells (hepatic macrophages) in liver sinusoids Copyright © 2010 Pearson Education, Inc. Interlobular veins (to hepatic vein) Central vein Sinusoids Bile canaliculi Plates of hepatocytes Bile duct (receives bile from bile canaliculi) Fenestrated lining (endothelial cells) of sinusoids Portal vein Hepatic macrophages in sinusoid walls Bile duct Portal venule Portal arteriole Portal triad (c) Copyright © 2010 Pearson Education, Inc. Figure 23.25c Liver: Microscopic Anatomy • Hepatocyte functions • Process bloodborne nutrients • Store fat-soluble vitamins • Perform detoxification • Produce ~900 ml bile per day Copyright © 2010 Pearson Education, Inc. Bile • Yellow-green, alkaline solution containing • Bile salts: function in fat emulsification and absorption • Bilirubin: pigment formed from heme • Cholesterol, triglycerides, phospholipids, and electrolytes Copyright © 2010 Pearson Education, Inc. Bile • Enterohepatic circulation • Recycles bile salts • Bile salts duodenum reabsorbed from ileum hepatic portal blood liver secreted into bile Copyright © 2010 Pearson Education, Inc. The Gallbladder • Thin-walled muscular sac on the ventral surface of the liver • Stores and concentrates bile by absorbing its water and ions • Releases bile via the cystic duct, which flows into the bile duct Copyright © 2010 Pearson Education, Inc.