Download Clinical Data Sharing

Database Design
CmpE 226
Practice Problems
Practice Problem (08)
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This problem statement was developed by
Team name: "Aces"
Members: Advait Kothare, German Serrano, Vijay Tandel, Huy Ho
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1. Design a database with at least 10-12 of tables or ((constraint tables. The constraint tables
should use the full power of linear constraints. (For example, the equality constraint x
=1 does not use the full power of linear constraints. So don ’t use only equality
constraints in your database.)) The tables should contain a reasonable number of tuples or
(constraint tuples), not too few and not too many.
2. Prepare traditional class diagram for the following problems showing at least 10 relationships
among the following object classes, including associations, aggregations, and
generalizations. Show multiplicities in your diagrams.
Your model should have 3-5 attributes and 3-5 operations per class. Use association and role
names when needed. As you prepare the diagrams, you may add additional object classes.
3. If you use MLPQ, find at least 4 iconic queries or sequence of iconic queries. Explain what
they mean and write them down in the style of the examples in the MLPQ system manual.
(Iconic queries are shown in Figure 1 MLPQ Graphical Interface in the MLPQ
Specifications, such as Intersection, Union, Difference, Max, Min, etc.)
4. Find at least 4 SQL queries of each of the following kind: Basic, Aggregation, Sets, and
Nested. (That is, a total of 16 queries.)
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Clinical Data Sharing
Abstract:
In this age of biotechnology, it is imperative to handle the great amount of research and clinical
data associated with the development and verification of medical devices and medication.
Because of this, the role of Clinical Research Organizations (CRO) has become more important,
as they act as consultants to help handle such information. Currently CRO handles and
distributes such information through telephone, fax, emails or courier. The CROs also store all
of this data on a paper-based file system. However, this mode of data handling is not efficient in
today’s environment, in which data has to be available instantly, and stored efficiently. Because
of this, a CRO offered the ACES team to develop a web-based database system to handle their
information and situation.
Description of Domains:
Based upon our understanding of the problem statement, the problem statement can be broken
down into three types of facilities/domains:
 A Clinical Research Organization (CRO)
 Customers to CRO (Pharmaceutical, Biotechnology and Medical Device Industries)
 Clinical Research Facilities (Hospitals and Universities)
The role of the clinical research organization is to act as a consultant to its main customers,
who are derived from the pharmaceutical, biotechnology and medical device industries. Their
role is to help these industries to test their products through research. Customers to CRO may
not have the resources or direction to perform such research to test their products. Because of
this, companies within these industries look to CROs to help navigate them to perform the
necessary research to test their products before the overall public uses them.
Because CRO acts more as a consultant rather than a proper research facility, CRO will
consult with clinical sites, such as hospital or universities, to help them perform the research that
is needed to help the CRO helps their customers. Clinical sites will perform the research needed,
and return to the CRO the necessary data for analysis.
Description of Desired Solution:
The CRO proposed to the ACES team a web-based database solution; the goal of this
web-based database solution is to help them handle the storage and transfer of information
efficiently through all three domains, which the current solution does not offer. Functions of the
web-based database include:
 All three domains will have permission to read, write, and modify the web-based
database.
 The web-based database will also provide access security to the domain.
Use Cases and User Context:
The users of this system within all three domains will be:
The CRO Domain:
 Consulting Team: The consulting team of the CRO is responsible for organizing the
research asked of them by a certain industry customer. The consulting team will require
the use of the web-based database in order for them to handle the data for their customer,
and to use that information for their consultation.
 Database Operator: The database operator of the CRO is responsible for managing the
web-based database. The database operator will require the use of the web-based
database in order to add, remove, or modify any data in the database
Clinical sites:
 Scientists: Scientists at the clinical sites are the ones who will perform the research
required to verify a certain medical product. Scientists will require the use of the webbased database in order to view previous research data, or any other data that may be
relevant to their research.
 Technicians: Technicians at the clinical sites are those who test the product and provide
test results. The will require the use of the web-based database in order to record test
results of specific products.

Database Operator: The database operator at the clinical site, similar to the database
operator at the CRO is responsible for managing the web-based database. The database
operator will require the use of the web-based database in order to add, remove, or
modify any data in the database.
Industries:
 Product Manager: The project manager specifies their products capabilities, benefits, and
particular users of a particular product that they would like research to done on. Project
managers will need to utilize the web-based database in order to store their products
information.
 Sales and marketing People: The sales and marketing people are the ones who will try to
promote their health products. They may use the web-based database in order to collect
data for their promotion.
Interfaces:
The interface for our system will be a web-browser, such as Internet Explorer, Netscape,
Mozilla, etc.
References:
www.clinimetrics.com