Download Puzzling Pedigrees Name___________________________

Puzzling Pedigrees
Graphic Organizer
Name: __________________________
Date____________Period___________
Answer the following questions with your elbow partner.
1. What physical traits did you inherit and from whom?
2. What traits can be inherited?
Write a definition for each word below, and a sentences that appropriately uses the word.
Word
Definition
Sentence
3. Pedigree
4. Genotype
5. Phenotype
Read page 396-397 out of the textbook. Answer the following questions:
6. What are pedigree charts?
7. What are the symbols and what do they mean?
8. In the sample pedigree pictured on page 397, what are the genotypes of both parents on the
left in the second generation? How do you know?
Guided Notes:
(AD) Autosomal dominant
(AR) Autosomal recessive
 Males & females are ___________likely to have the trait
 Males & females are ___________ likely to have the trait
 Traits _____________skip generation
 Trait often ____________ generations
 Males can transmit to _________sons and daughters
 Only _____________ individuals have the trait
 The trait is present whenever the corresponding ________ is  Parents who have children with the trait must be ____________
 If a parent has the trait, their offspring who do not have it are
present
heterozygous ________________ for the trait
(XD) X-linked dominant
(XR) X-linked recessive
 Trait is coded for on the _____ chromosome
 Trait is coded for on the ______ chromosome
 All ___________ of a male who ______ the trait will also
 Trait more ______________ in males than females
have the trait
 A father ______________ pass the trait on to their daughter
 If a male has the trait, all of his ____________ will be
heterozygous _______________
 A female who has the trait may or may not pass the ______  Sons of female carriers have a _______ chance of having the trait
 Males can not pass the trait to their sons
for that trait to her son or daughter
 A male inherits the trait from his _________ who is a carrier
 Daughters of female carriers have a ___ chance of being a carrier
Partner Activity: Refer to the following 8 pedigrees showing the inheritance of 8 human traits.
Using the chart determine the pattern of inheritance for each pedigree. Write the letters from above in
the blanks below.
9.
13.
10.
14.
11.
15.
12.
16.
Pedigree Problems:
17. The pedigree below traces the inheritance of alkaptonuria, a biochemical disorder. Affected
individuals, indicated here by the filled-in circles and squares, are unable to break down a substance
called alkapton, which colors the urine and stains body tissues.
a. Does alkaptonuria appear to be caused by a dominant
or recessive allele?
____________________________
b. Fill in the genotypes of the following individuals (use
A and a):
George ______
Arlene______
Carla ______
Michael ______
Tom ______
c. Fill in the possible genotypes for Christopher:
_______ or ______
18. The pedigree below traces the inheritance of Huntington’s disease, a neurodegenerative genetic
disorder that affects muscle coordination and leads to cognitive decline and psychiatric problems.
Affected individuals are indicated by filled-in circles and squares.
a. Does Huntington’s appear to be caused by a dominant
or recessive allele?
_____________________________________
b. Fill in the genotype of the following individuals (use H
and h):
Bob ______
Barb ______
Charlie ______
Ethan ______
Candice ______ Isabelle ______
c. What are Candice’s chances of having a child with Huntington’s disease if she marries a
male without the gene? ________
19. The pedigree below traces the inheritance of Hemophilia, an x-linked recessive disorder, that
effects the ability for blood to clot.
a. Fill in the genotype of the following
individuals (use X, Y, and Xh):
Edward VII ______ Alice ______
Queen Victoria ______
Leopold ______
Beatrice______
Henry of Prussia ______
b.
What are the chances of Leopold’s
daughter having hemophelia if he marry’s a
non-carrier female?
20. Oscar Grouch and Vanessa Grouch had five children. Two of them married (Calvin and
Margaret). Calvin married Stephanie, Margaret married Eric. Margaret and Eric had three children
(Nancy and Ingrid). Nancy married Larry, Ingrid married Paul. Calvin and Stephanie also had three
children (Douglas and Thomas). Douglas married Xantha, and Thomas married Claire.
Oscar and Vanessa had 10 great-grandchildren (3 great-granddaughters and 7 great-grandsons). Larry
and Nancy had three children, Quinn, Wayne, and Kim. Kim has two cousins, Henry and Greg. Kim
has an aunt Ingrid, and an uncle Frank. Douglas and Xantha had a son and a daughter. Thomas and
Claire had three children (Alex, Ben, and Jennifer). Jennifer’s cousins are named Zachary and
Yianna. Alex has a brother-in-law, Ulysses. Alex also has an uncle named Richard. Richard has two
unmarried aunts named Anne and Diane and an unmarried uncle named Fred.
a. Create a pedigree showing the relationships between all the members of the Grouch family.
b. The Grouch family has several members who are color-blind. This is a recessive sexlinked trait. Oscar is color-blind, and his wife Vanessa is a carrier. Their son Calvin is colorblind, their grandson Zach is color-blind, and their great grandchildren Wayne & Henry are
color-blind. Shade in the boxes of of those who are color-blind, and work backwards to
determine who must be carriers. Identify carriers with a dot.
Methemoglobinemia
Background:
20. Hemoglobin is the iron-containing __________-transport
_________ in the red blood cells.
Methemoglobin is a form of ______________ that can’t bind
___________. When excess methlemoglobin is present, the
________ becomes abnormally __________ and can cause some
_______ discoloration.
Article Read: “The Blue People of Troublesome Creek”
21. Read paragraphs 1-20. Stop and write a short summary of what you read.
22. Read paragraphs 21-40. Stop and write a short summary of what you read.
23. Read paragraphs 41-58. Stop and write a short summary of what you read.
Answer the following questions:
24. What is the name of the disorder described in the article?
25. Describe the group of people effected by this disorder.
26. Is the disorder autosomal or x-linked?
27. Is the disorder recessive or dominant?
28. Where did this population reside?
29. Describe the symptoms of the disorder?
30. How was this disorder inherited?
31. Why was the disorder isolted to this population?
32. My Family Pedigree: Draw a pedigree chart of your family including yourself, your parents, and
your siblings. Include grandparents if possible. Idenitfy and color symbols accordingly for one of
the following traits:
 Right (Dominant) or left handed (recessive)
 Freckles (Dominant) or No Freckles (recessive)
 Detached (Dominant) or attached earlobes (recessive)
 Widows peak (Dominant) or Straight Hair Line (recessive)
 Togue roller/non-roller