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1. RrLl x RrLl What fraction are purple and long? (½ Rr)(¼ LL) = ⅛ RrLL Ans: (b) 2. In this cross, we see that the inheritance pattern in the F1 shows a ‘criss-cross’ similar to that observed for the white eye phenotype in Drosophila- only the sexes are reversedyellow males give rise only to green females. Remember, however, that females in birds are the heterogametic sex (ZW), and males are the homogametic sex (ZZ). The crosses can therefore be interpreted as: ZyZy (yellow male)x ZYW (green female), where the green allele (ZY) is dominant over the yellow allele (Zy) The F1 progeny would therefore be green males (ZyZY) and yellow females (ZyW). This is a single gene locus with complete dominance and sex-linked expression- none the above are true (e). 3. green males (ZyZY) x yellow females (ZyW) ¼ ZyZy (yellow males) ¼ ZyW (yellow females) ¼ ZYZy (green males) ¼ ZYW (green females) All of the above are true (d) 4. c+ > cch > cc > c 4 homozygotes: c+c+; cchcch; chch; cc; 6 heterozygotes c+cch; c+ch; c+c; cchch; cchc; chc Ans: 10 total (c) + h ch 5. c c x c c ¼ c+cch (agouti) ¼ c+c (agouti) ¼ chcch (chinchilla) ¼ chc (himalaya) 2 agouti: 1 chinchilla : 1 himalaya none of the above (e) 6. This is discussed on page 69 of your text. The myocilin gene is associated with a form of juvenile glaucoma; there are multiple allelic variants and not all individuals heterozygous for the mutations manifest the disease. Ans (b) The orientation of the alleles in the heterozygous parent is: + b y + Phenotype Progeny Recovered 4 byp 93 by+ 54 b+p 349 b++ 331 +yp 66 +y+ 97 ++p 6 +++ Total 1000 + p 7. + + p 97 y b + 93 +++ 6 ybp 4 Total 200 200/1000 = 0.2 = 20 map units between y and b. + b p 54 y + + 66 +++ 6 ybp 4 Total 130 130/1000 = 0.13 = 13 map units between b and p. The distance between y and p would therefore be 20 + 13 = 33 map units Ans: greater than 30 (e) 8. (0.2)(0.13)(1000) = 26 expected DCOs COC = observed DCOs/expected DCOs = 10/26 = 0.385 Ans: (c) Classes 1 and 2 Spore pairs 3 and 4 5 and 6 7 and 8 total Ditype Segreg. 1 ag ++ ag ++ 1 NPD 2:2 2 a+ ++ ag +g 37 TT 2:1 3 ag ag ++ ++ 2 NPD 1:1 4 ag ++ a+ +g 3 TT 2:2 5 a+ +g a+ +g 3 PD 2:2 6 a+ a+ +g +g 316 PD 1:1 PD >>NPD (319>>3), so genes are linked Centromere to a distance: ½ * (1+ 37 + 3 + 3)/437 = 0.05 (5 m.u.) Centromere to g distance: ½ * (1+ 3 + 3 + 75)/437 = 0.094 (9.4 m.u.) a to g distance: [½ (37 + 3 + 75)] + 3(1 + 2)/437 = 15.2 map units 9. Genes are on either side of the centromere: Ans: (c) 10. Centromere to a distance is 5 map units Ans: (a) 7 ag a+ ++ +g 75 TT 1:2